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Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Scaling NavSTAR patient navigation across a health system

Official title: Implementing a Patient Navigation Intervention Across a Health System to Improve Outcomes for Patients With Opioid Use Disorder

Run by Friends Research Institute, Inc. · NCT07262190 · Data updated 2026-11-12

This project will test whether NavSTAR, a hospital-to-community patient navigation program, helps adults with moderate-to-severe opioid use disorder start and stay in opioid agonist treatment after discharge.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment720 (estimated)
SponsorFriends Research Institute, Inc.
Academic / other
Locations1 site (Philadelphia, Pennsylvania)
StatusRecruiting
StartedOctober 27, 2025
Main results expectedJanuary 1, 2029
Study endsAugust 1, 2029
Registry record updatedDecember 3, 2025
Trial IDNCT07262190 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (18+) hospitalized in Philadelphia who meet DSM-5 criteria for moderate-to-severe opioid use disorder and can consent in English, and who are not already in recent OUD treatment, pregnant, being discharged to long-term inpatient care, or hospitalized for a suicide attempt.

Probably not a fit

People already enrolled in OUD treatment within 30 days, residents outside the City of Philadelphia, pregnant people, or those being discharged to long-term inpatient care or hospitalized for a suicide attempt are not eligible and therefore would not receive benefit from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This type II hybrid implementation-effectiveness project will pilot and then test NavSTAR, a patient navigation program that helps hospitalized adults with opioid use disorder connect to opioid agonist treatment (OAT) and community supports after discharge. The team will first pilot NavSTAR with 32 patients across four Philadelphia hospitals and then enroll about 720 patients to test an Implementation Facilitation strategy for scaling across a health system. Primary outcomes include OAT initiation and hospital readmissions, along with reach, sustainability, and implementation process measures. The effort builds on a prior single-site randomized trial and engages hospital, community, and patient partners to address barriers to broad delivery.

Why it matters

Potential benefit: If successful, NavSTAR could help more hospitalized patients with opioid use disorder start OAT, reduce rehospitalizations, and expand navigation services across health systems.

How similar studies have gone: A prior single-site randomized trial of NavSTAR with 400 participants increased OAT entry, reduced readmissions, and was highly cost-effective, so this study focuses on scaling those findings across multiple hospitals.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. age 18 or older;
2. current DSM-5 criteria for moderate to severe OUD;
3. willing and able to provide informed consent in English.

Exclusion Criteria:

1. enrollment in OUD treatment 30-days prior to hospitalization;
2. residency outside the City of Philadelphia;
3. pregnancy;
4. planned discharge to a long-term inpatient care facility (e.g., hospice);
5. hospitalization for a suicide attempt.

Where it's running

  • Jefferson Health
    Philadelphia, Pennsylvania, United States     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Opioid Use Disorder 579Friends Research Institute, INC. 30
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.