Helping opioid treatment clinics track and improve patient retention
Official title: Research to Foster an Opioid Use Disorder Treatment System Patients Can Count On: Project 2 - Producing Outcome Measures for OTP Quality Improvement
Run by RTI International · NCT07214389 · Data updated 2026-11-12
This project tests whether giving opioid treatment clinics retention and outcome measures plus a quality-improvement toolkit, with or without extra coaching, helps people stay on methadone or buprenorphine.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 4500 (estimated) |
| Sponsor | RTI International Academic / other |
| Locations | 1 site (Research Triangle Park, North Carolina) |
| Status | Recruiting |
| Started | October 3, 2025 |
| Main results expected | August 1, 2027 |
| Study ends | December 1, 2027 |
| Registry record updated | August 27, 2026 |
| Trial ID | NCT07214389 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
The project focuses on patients receiving methadone or buprenorphine at participating BayMark opioid treatment programs, especially those newly starting treatment.
✕Probably not a fit
People who receive care outside the BayMark network or who are not on methadone or buprenorphine would not be affected by the interventions in this project.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This cluster-randomized trial will enroll 45 BayMark opioid treatment programs (about 15 sites per arm) and compare three approaches: quality measures plus a QI toolkit, those components plus external QI facilitation (NIATx), and usual care. The trial will use electronic health records and Medicaid claims to measure outcomes for roughly 4,500 medication-for-opioid-use-disorder (MOUD) starts during a 12-month observation window. The primary outcome is 90-day treatment retention; secondary outcomes include emergency department visits, hospitalizations, overdoses, and mortality. The goal is to identify practical, scalable strategies that clinics can use to keep patients engaged in treatment.
Why it matters
Potential benefit: If successful, this could help more people stay on methadone or buprenorphine and reduce emergency visits, hospitalizations, and overdoses.
How similar studies have gone: Similar audit-and-feedback and NIATx-style quality-improvement approaches have shown promise in improving engagement in behavioral health settings, though results have varied by setting and implementation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Only BayMark OTPs are eligible for participation.
Where it's running
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RTI International
Research Triangle Park, North Carolina, United States Recruiting
Study contacts
- Principal investigator: Tami L Mark, PhD — RTI International
- Study coordinator: Tami L Mark, PhD
- Email: tmark@rti.org
- Phone: 301-816-4612
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CB1 Receptors in Opioid Use Disorder Measured with a PET Radioligand
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STORC: Training a support person plus patient navigation after birth
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.