Helping opioid treatment clinics track and improve patient retention

Research to Foster an Opioid Use Disorder Treatment System Patients Can Count On: Project 2 - Producing Outcome Measures for OTP Quality Improvement

Not applicable Interventional RTI International · NCT07214389

This project tests whether giving opioid treatment clinics retention and outcome measures plus a quality-improvement toolkit, with or without extra coaching, helps people stay on methadone or buprenorphine.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment4500 (estimated)
Ages18 Years and up
SexAll
SponsorRTI International Academic / other
Locations1 site (Research Triangle Park, North Carolina)
Trial IDNCT07214389 on ClinicalTrials.gov

What this trial studies

This cluster-randomized trial will enroll 45 BayMark opioid treatment programs (about 15 sites per arm) and compare three approaches: quality measures plus a QI toolkit, those components plus external QI facilitation (NIATx), and usual care. The trial will use electronic health records and Medicaid claims to measure outcomes for roughly 4,500 medication-for-opioid-use-disorder (MOUD) starts during a 12-month observation window. The primary outcome is 90-day treatment retention; secondary outcomes include emergency department visits, hospitalizations, overdoses, and mortality. The goal is to identify practical, scalable strategies that clinics can use to keep patients engaged in treatment.

Who should consider this trial

Good fit: The project focuses on patients receiving methadone or buprenorphine at participating BayMark opioid treatment programs, especially those newly starting treatment.

Not a fit: People who receive care outside the BayMark network or who are not on methadone or buprenorphine would not be affected by the interventions in this project.

Why it matters

Potential benefit: If successful, this could help more people stay on methadone or buprenorphine and reduce emergency visits, hospitalizations, and overdoses.

How similar studies have performed: Similar audit-and-feedback and NIATx-style quality-improvement approaches have shown promise in improving engagement in behavioral health settings, though results have varied by setting and implementation.

Eligibility criteria

Show full inclusion / exclusion criteria
Only BayMark OTPs are eligible for participation.

Where this trial is running

Research Triangle Park, North Carolina

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Opioid Use DisorderOpioid Treatment ProgramsMethadoneBuprenorphineQuality ImprovementTreatment RetentionAddiction ServicesImplementation Science
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.