Buprenorphine access at syringe service programs to reduce overdoses

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a cluster-randomized, stepped-wedge study across eight syringe service programs in urban, suburban, and rural US settings. It compares standard referral to onsite, low-threshold buprenorphine treatment to see if easier access improves engagement and outcomes for adults with moderate to severe opioid use disorder who are SSP clients. Each site transitions from referral to onsite treatment over time, allowing each to serve as its own control. The design accounts for timing and local readiness to implement the intervention while collecting data before and after rollout. The trial aims to understand both effectiveness and implementation feasibility of integrating MOUD at SSPs.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. ≥ 18 years old;
2. Meet DSM-5 criteria for moderate or severe OUD;
3. Interest in receiving buprenorphine treatment;
4. Speaks English or Spanish;
5. Currently an SSP client at the time of enrollment;
6. Ability to provide informed consent.

Exclusion Criteria:

1. Current use of prescribed opioid agonist treatment, as assessed by self-report, at the time of enrollment;
2. Unstable mental health or medical condition that requires an immediate clinical evaluation or higher level of care;
3. Allergy to buprenorphine;
4. Currently detained in jail, prison, residential substance use treatment facility, or other overnight facility as required by court of law. or have pending legal action that could prevent participation on study activities.

Where it's running

• Community Health Project Los Angeles (CHPLA)
  Los Angeles, California, United States Recruiting
• Hips
  Washington D.C., District of Columbia, United States Recruiting
• CARPBR/Be Safe Syringe Program
  Baton Rouge, Louisiana, United States Recruiting
• Harm Reduction Sisters
  Duluth, Minnesota, United States Recruiting
• Alianza of New Mexico
  Roswell, New Mexico, United States Recruiting
• HIV Alliance
  Grants Pass, Oregon, United States Recruiting

Study contacts

• Principal investigator: Aaron D Fox, MD, MS — Albert Einstein College of Medicine
• Study coordinator: Megan M Ghiroli
• Email: mghiroli@montefiore.org
• Phone: 12036068136

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.