Integrating social risk information into opioid treatment in the emergency department
Official title: Using Clinical Decision Support to Provide Social Risk-Informed Care for Opioid Use Disorder in the Emergency Department
Run by University of California, San Francisco · NCT06872190 · Data updated 2026-11-12
This study is testing a new tool that adds social risk information to help emergency department patients with opioid use disorder stick to their treatment plans better.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | University of California, San Francisco Academic / other |
| Locations | 1 site (San Francisco, California) |
| Status | Recruiting |
| Started | April 20, 2025 |
| Main results expected | July 2027 |
| Study ends | July 2027 |
| Registry record updated | June 29, 2026 |
| Trial ID | NCT06872190 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include English-speaking adults aged 18 and older presenting to the UCSF emergency department with opioid use disorder who receive medication treatment.
✕Probably not a fit
Patients with medical or psychiatric conditions requiring hospitalization, those who are actively suicidal, cognitively impaired, or presenting from extended care facilities may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to enhance an existing clinical decision support tool by incorporating social risk information to improve medication treatment adherence for patients with opioid use disorder in the emergency department. It will evaluate the feasibility and acceptability of this enhanced tool compared to the original version at a single site, UCSF. The approach involves a mixed-methods, before-after design to assess the impact on treatment adherence and follow-up care for adult patients experiencing opioid use disorder.
Why it matters
Potential benefit: If successful, this approach could lead to improved treatment adherence and better health outcomes for patients with opioid use disorder.
How similar studies have gone: Other studies have shown success with similar clinical decision support approaches, indicating potential for this method to improve treatment outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: * All University of California, San Francisco ED providers (residents, attendings, advanced practice providers) who have used either CDSv1 or CDSv2 will be eligible to participate in surveys and interviews regarding feasibility and acceptability. * English-speaking patients ≥18 years of age presenting to the UCSF ED with opioid use disorder who receive medication treatment (as a result of CDSv1 or CDSv2) will be eligible to participate. Exclusion criteria: \- Participants will be excluded if: * they have a medical or psychiatric condition requiring hospitalization at the index ED visit, * are actively suicidal, are cognitively impaired, * present from an extended care facility, or * require opioids for a pain condition.
Where it's running
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University of California, San Francisco
San Francisco, California, United States Recruiting
Study contacts
- Principal investigator: Melanie F Molina, MD, MAS — University of California, San Francisco
- Study coordinator: Melanie F Molina, MD, MAS
- Email: melanie.molina@ucsf.edu
- Phone: 415-353-1156
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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CBD for Opioid Dependence and Pain on Buprenorphine
This study tests whether different doses of cannabidiol (CBD) can affect pain and opioid cravings in adults with opioid use disorder who are on buprenorphine, using a short, randomized, placebo-controlled setup.
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Cebranopadol for opioid withdrawal in adults with chronic pain
This study tests whether cebranopadol can reduce withdrawal symptoms in adults with chronic pain who are physically dependent on prescribed opioids, compared with placebo.
-
emPath platform pilot to link and keep adults with opioid use disorder in care in Durham
This pilot tests a mobile app and telemedicine approach to help adults with opioid use disorder start and stay in MOUD through community outreach in Durham, NC.
-
CB1 Receptors in Opioid Use Disorder Measured with a PET Radioligand
This study tests CB1 receptor availability in people with opioid use disorder starting opioid agonist therapy and compares them with healthy adults.
-
Linking social care with healthcare to help manage chronic diseases
This trial tests whether pairing patients with trained community health workers can help them get transportation, healthy food, information, and better access to care to improve health in conditions like hypertension, diabetes, and high cholesterol.
-
STORC: Training a support person plus patient navigation after birth
We’re testing whether training a designated support person and using patient navigation after delivery helps people with opioid use disorder build recovery resources and stay in treatment.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.