Coordinating outpatient buprenorphine care after an ED visit
Official title: Coordinating Outpatient bupreNorphiNe for Emergency Care and Continuing Treatment
Run by University of California, Davis · NCT07024498 · Data updated 2026-11-12
This study tests a bundle of strategies to improve how EDs link patients who start buprenorphine to outpatient care, to see if it helps people stay on treatment longer.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 14 Years and up |
| Sex | All |
| Enrollment | 3492 (estimated) |
| Sponsor | University of California, Davis Academic / other |
| Locations | 4 sites (El Centro, California and 3 other locations) |
| Status | Recruiting |
| Started | November 1, 2025 |
| Main results expected | August 1, 2028 |
| Study ends | August 1, 2029 |
| Registry record updated | June 12, 2026 |
| Trial ID | NCT07024498 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with opioid use disorder who start buprenorphine in a participating ED and are referred to outpatient care.
✕Probably not a fit
Patients who do not pursue or continue outpatient buprenorphine after ED initiation may not experience the intended benefits.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a stepped-wedge trial across 12 sites (4 EDs and 8 outpatient clinics) testing implementation strategies to improve ED-to-outpatient care coordination for adults who start buprenorphine in the ED. The study uses electronic health records to identify eligible patients and to track outcomes such as days on prescribed buprenorphine at 3, 6, and 12 months, continuity of coverage, and timely outpatient prescriptions. Data on care coordination will be gathered from medical records and clinician surveys. The aim is to determine whether the bundled strategies increase retention and continuity of buprenorphine treatment after ED initiation. It is a hybrid effectiveness-implementation study conducted with California-based sites and led by UC Davis with NIDA collaboration.
Why it matters
Potential benefit: If successful, patients could have longer, uninterrupted access to buprenorphine after an ED visit, reducing cravings and overdose risk.
How similar studies have gone: Prior work suggests care-coordination interventions can improve treatment continuity, but this exact bundled implementation approach is being tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients who start buprenorphine for opioid use disorder at a participating ED
Where it's running
-
Marshall Medical Center Emergency Department
Placerville, California, United States Recruiting -
University of California Davis Emergency Department
Sacramento, California, United States Recruiting -
El Centro Regional Medical Center Emergency Department
El Centro, California, United States Not yet recruiting -
University of California Irvine Emergency Department
Irvine, California, United States Not yet recruiting
Study contacts
- Principal investigator: Stephen G Henry, MD MSc — University of California, Davis
- Study coordinator: Marykate MIller, MPH
- Email: mkemiller@health.ucdavis.edu
- Phone: 916-734-2877
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.