Injectable buprenorphine options to support release from prison

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a pilot hybrid effectiveness-implementation study comparing two extended-release buprenorphine formulations (Sublocade and Brixadi) in individuals transitioning from prison to the community. A partially randomized preference design assigns participants to their preferred formulation or randomizes those without a strong preference, to see how choice affects retention and other outcomes. The study will measure post-release treatment retention, feasibility, acceptability, and fidelity of the administration in a correctional setting, with a collaboration between Lifespan, NIDA, and RIDOC in Rhode Island. Participants must be adults with opioid use disorder, enrolled in RIDOC MOUD, and nearing release, among other criteria. Results may inform how patient preference and formulation choice influence real-world treatment continuity after incarceration.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. be at least 18 years of age and incarcerated in the RIDOC facility,
2. be currently diagnosed with OUD and enrolled in the RIDOC MOUD program,
3. have an expected release date within 120 days of study enrollment,
4. have an interest in XR-B and
5. be English speaking

Exclusion Criteria:

1. individuals who are pregnant or planning conception,
2. diagnosed with a severe or acute medical or psychiatric disability preventing safe study participation or making follow-up unlikely,
3. have a release date within 21 days of initiation, or
4. have previously had an allergy to buprenorphine. Post-enrollment exclusion will include individuals if there is a change in release date beyond the 120 days and therefore no longer meet original inclusion criteria. These individuals would return to usual MOUD care.

Where it's running

• Rhode Island Department of Corrections
  Cranston, Rhode Island, United States Recruiting

Study contacts

• Study coordinator: Justin Berk, MD MPH MBA
• Email: justin_berk@brown.edu
• Phone: (401) 680-1074

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• CBD for Opioid Dependence and Pain on Buprenorphine

  This study tests whether different doses of cannabidiol (CBD) can affect pain and opioid cravings in adults with opioid use disorder who are on buprenorphine, using a short, randomized, placebo-controlled setup.

  Recruiting Early Phase 1 Yale University · West Haven, Connecticut · NCT07886606

• Cebranopadol for opioid withdrawal in adults with chronic pain

  This study tests whether cebranopadol can reduce withdrawal symptoms in adults with chronic pain who are physically dependent on prescribed opioids, compared with placebo.

  Recruiting at 2 sites Phase 2 Adneuris Therapeutics, Inc. · North Canton, Ohio and 1 other locations · NCT07874620

• emPath platform pilot to link and keep adults with opioid use disorder in care in Durham

  This pilot tests a mobile app and telemedicine approach to help adults with opioid use disorder start and stay in MOUD through community outreach in Durham, NC.

  Recruiting Duke University · Durham, North Carolina · NCT07810322

• CB1 Receptors in Opioid Use Disorder Measured with a PET Radioligand

  This study tests CB1 receptor availability in people with opioid use disorder starting opioid agonist therapy and compares them with healthy adults.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT07800520

• STORC: Training a support person plus patient navigation after birth

  We’re testing whether training a designated support person and using patient navigation after delivery helps people with opioid use disorder build recovery resources and stay in treatment.

  Recruiting Friends Research Institute, Inc. · Philadelphia, Pennsylvania · NCT07787039

• Personalized Addiction Treatment Enhancement for Opioid Use Disorder

  A digital platform run by peer recovery supporters will be tested to help adults with opioid use disorder who are on buprenorphine or methadone stay in treatment and improve outcomes.

  Recruiting Rhode Island Hospital · Providence, Rhode Island · NCT07778394

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.