Access to HIV prevention and opioid use disorder treatment for people who inject drugs
Official title: PrEP and MOUD Rapid Access for Persons Who Inject Drugs: The CHORUS+ Study
Run by Boston Medical Center · NCT05769218 · Data updated 2026-11-12
This study is testing a new way to help people who inject drugs get better access to HIV prevention and treatment for opioid use disorder by using peer support and mobile phone tools.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 284 (estimated) |
| Sponsor | Boston Medical Center Academic / other |
| Locations | 2 sites (Boston, Massachusetts and 1 other locations) |
| Status | Recruiting |
| Started | December 19, 2024 |
| Main results expected | July 1, 2027 |
| Study ends | June 30, 2028 |
| Registry record updated | April 6, 2026 |
| Trial ID | NCT05769218 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals who have injected opioids in the past six months and are at risk for HIV.
✕Probably not a fit
Patients who are already living with HIV or are pregnant may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The CHORUS+ initiative aims to improve the uptake and adherence to HIV pre-exposure prophylaxis (PrEP) and the continuation of medication for opioid use disorder (MOUD) among individuals who inject opioids. This intervention utilizes a peer-delivered, mobile phone-supported approach that includes HIV self-testing and rapid initiation of PrEP. By addressing the barriers to accessing these critical health services, the study seeks to enhance health outcomes for this vulnerable population. Participants will be recruited from the Boston area and will receive support through motivational interviewing and peer recovery coaching.
Why it matters
Potential benefit: If successful, this study could significantly reduce the risk of HIV transmission and improve treatment adherence for individuals with opioid use disorder.
How similar studies have gone: Other studies have shown success in using peer-delivered interventions to improve health outcomes in similar populations, suggesting a promising approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Injected opioids within the past 6 months (by self-report) * Willingness to provide contact information for two family members or friends * Willingness to sign medical records release forms * Ability to speak English * Plans to reside in Boston area for the next 6 months * Are medically cleared to take PrEP and MOUD (normal renal and PrEP-related labs) Exclusion Criteria: * Persons with previous HIV diagnosis (by self-report; confirmed via HIV test result) * Express desire to harm themselves or others * Individuals who are pregnant at baseline * Individuals who are already enrolled in an interventional study
Where it's running
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Boston Medical Center Faster Paths Bridge Clinic
Boston, Massachusetts, United States Recruiting -
Victory Programs Mobile Prevention Services Van and Navigation Center
Boston, Massachusetts, United States Recruiting
Study contacts
- Principal investigator: Sabrina A Assoumou, MD MPH — Boston Medical Center, Infectious Diseases
- Study coordinator: Sabrina A Assoumou, MD MPH
- Email: sabrina.assoumou@bmc.org
- Phone: 617-414-2857
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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CBD for Opioid Dependence and Pain on Buprenorphine
This study tests whether different doses of cannabidiol (CBD) can affect pain and opioid cravings in adults with opioid use disorder who are on buprenorphine, using a short, randomized, placebo-controlled setup.
-
Cebranopadol for opioid withdrawal in adults with chronic pain
This study tests whether cebranopadol can reduce withdrawal symptoms in adults with chronic pain who are physically dependent on prescribed opioids, compared with placebo.
-
emPath platform pilot to link and keep adults with opioid use disorder in care in Durham
This pilot tests a mobile app and telemedicine approach to help adults with opioid use disorder start and stay in MOUD through community outreach in Durham, NC.
-
CB1 Receptors in Opioid Use Disorder Measured with a PET Radioligand
This study tests CB1 receptor availability in people with opioid use disorder starting opioid agonist therapy and compares them with healthy adults.
-
STORC: Training a support person plus patient navigation after birth
We’re testing whether training a designated support person and using patient navigation after delivery helps people with opioid use disorder build recovery resources and stay in treatment.
-
Personalized Addiction Treatment Enhancement for Opioid Use Disorder
A digital platform run by peer recovery supporters will be tested to help adults with opioid use disorder who are on buprenorphine or methadone stay in treatment and improve outcomes.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.