Clinical trial Recruiting at 2 sites Interventional Ages 18 and up

Access to HIV prevention and opioid use disorder treatment for people who inject drugs

Official title: PrEP and MOUD Rapid Access for Persons Who Inject Drugs: The CHORUS+ Study

Run by Boston Medical Center · NCT05769218 · Data updated 2026-11-12

This study is testing a new way to help people who inject drugs get better access to HIV prevention and treatment for opioid use disorder by using peer support and mobile phone tools.

More Opioid Use Disorder trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment284 (estimated)
SponsorBoston Medical Center
Academic / other
Locations2 sites (Boston, Massachusetts and 1 other locations)
StatusRecruiting
StartedDecember 19, 2024
Main results expectedJuly 1, 2027
Study endsJune 30, 2028
Registry record updatedApril 6, 2026
Trial IDNCT05769218 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are individuals who have injected opioids in the past six months and are at risk for HIV.

Probably not a fit

Patients who are already living with HIV or are pregnant may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The CHORUS+ initiative aims to improve the uptake and adherence to HIV pre-exposure prophylaxis (PrEP) and the continuation of medication for opioid use disorder (MOUD) among individuals who inject opioids. This intervention utilizes a peer-delivered, mobile phone-supported approach that includes HIV self-testing and rapid initiation of PrEP. By addressing the barriers to accessing these critical health services, the study seeks to enhance health outcomes for this vulnerable population. Participants will be recruited from the Boston area and will receive support through motivational interviewing and peer recovery coaching.

Why it matters

Potential benefit: If successful, this study could significantly reduce the risk of HIV transmission and improve treatment adherence for individuals with opioid use disorder.

How similar studies have gone: Other studies have shown success in using peer-delivered interventions to improve health outcomes in similar populations, suggesting a promising approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Injected opioids within the past 6 months (by self-report)
* Willingness to provide contact information for two family members or friends
* Willingness to sign medical records release forms
* Ability to speak English
* Plans to reside in Boston area for the next 6 months
* Are medically cleared to take PrEP and MOUD (normal renal and PrEP-related labs)

Exclusion Criteria:

* Persons with previous HIV diagnosis (by self-report; confirmed via HIV test result)
* Express desire to harm themselves or others
* Individuals who are pregnant at baseline
* Individuals who are already enrolled in an interventional study

Where it's running

  • Boston Medical Center Faster Paths Bridge Clinic
    Boston, Massachusetts, United States
    Recruiting
  • Victory Programs Mobile Prevention Services Van and Navigation Center
    Boston, Massachusetts, United States
    Recruiting

Study contacts

  • Principal investigator: Sabrina A Assoumou, MD MPH — Boston Medical Center, Infectious Diseases
  • Study coordinator: Sabrina A Assoumou, MD MPH
  • Email: sabrina.assoumou@bmc.org
  • Phone: 617-414-2857

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.