Boosting medication start and stay rates for people with opioid use disorder by adding peer support at mobile clinics
Official title: Data-Driven Approaches for Opioid Use Disorder Treatment, Recovery, and Overdose Prevention in Rural Communities Via Mobile Health Clinics and Peer Support Services
Run by Prisma Health-Upstate · NCT07541417 · Data updated 2026-11-12
This project will test whether adding trained peer support specialists at Prisma Health mobile clinics helps adults with opioid use disorder start and stay on medication treatment.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 750 (estimated) |
| Sponsor | Prisma Health-Upstate Academic / other |
| Locations | 1 site (Greenville, South Carolina) |
| Status | Recruiting |
| Started | April 8, 2026 |
| Main results expected | February 28, 2029 |
| Study ends | August 31, 2029 |
| Registry record updated | April 28, 2026 |
| Trial ID | NCT07541417 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older with a diagnosis of opioid use disorder who are new patients seeking MOUD at Prisma Health mobile clinics in South Carolina and can provide informed consent are ideal candidates.
✕Probably not a fit
People already working with a certified peer support specialist, those with severe medical or psychiatric conditions that prevent participation, or those unable to read and understand consent materials are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized controlled trial will enroll 750 adults with moderate to severe opioid use disorder who are new mobile health MOUD patients at Prisma Health Upstate in South Carolina. Participants will be randomized 1:1 to receive either the mobile health clinic (MHC) standard protocol or MHC plus a Certified Peer Support Specialist (PSS) delivering Assertive Community Engagement services. The trial will follow participants for six months and measure primary outcomes of MOUD initiation and retention, with secondary analyses including cost-effectiveness and optimization of mobile clinic–PSS allocation. The intervention links patients visiting mobile clinics to peers in recovery who provide targeted recovery support to improve engagement and reduce overdose risk.
Why it matters
Potential benefit: If successful, this approach could increase initiation and longer-term retention on medications for opioid use disorder and help prevent overdose deaths in underserved communities.
How similar studies have gone: Prior research on peer support and mobile delivery of MOUD has shown promising improvements in engagement and retention, though large randomized trials remain limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18+ * Have diagnosis of OUD * New mobile health MOUD patient Exclusion Criteria: * Unable to read and comprehend the consent materials and other study materials * Currently working with a Certified Peer Support Specialist * Having severe medical or psychiatric disability that would hinder participation in the study, as determined by the clinical provider
Where it's running
-
Prisma Health Upstate
Greenville, South Carolina, United States Recruiting
Study contacts
- Study coordinator: Ashley King, MSW
- Email: ashley.king3@prismahealth.org
- Phone: 7049369402
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
CBD for Opioid Dependence and Pain on Buprenorphine
This study tests whether different doses of cannabidiol (CBD) can affect pain and opioid cravings in adults with opioid use disorder who are on buprenorphine, using a short, randomized, placebo-controlled setup.
-
Cebranopadol for opioid withdrawal in adults with chronic pain
This study tests whether cebranopadol can reduce withdrawal symptoms in adults with chronic pain who are physically dependent on prescribed opioids, compared with placebo.
-
emPath platform pilot to link and keep adults with opioid use disorder in care in Durham
This pilot tests a mobile app and telemedicine approach to help adults with opioid use disorder start and stay in MOUD through community outreach in Durham, NC.
-
CB1 Receptors in Opioid Use Disorder Measured with a PET Radioligand
This study tests CB1 receptor availability in people with opioid use disorder starting opioid agonist therapy and compares them with healthy adults.
-
STORC: Training a support person plus patient navigation after birth
We’re testing whether training a designated support person and using patient navigation after delivery helps people with opioid use disorder build recovery resources and stay in treatment.
-
Personalized Addiction Treatment Enhancement for Opioid Use Disorder
A digital platform run by peer recovery supporters will be tested to help adults with opioid use disorder who are on buprenorphine or methadone stay in treatment and improve outcomes.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.