EMS-initiated buprenorphine for opioid use disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project uses multiple EMS sites to first run pragmatic, prehospital field studies to gauge feasibility, acceptability, and safety of an EMS-initiated buprenorphine protocol. A subsequent single-arm prospective trial will enroll about 100 patients per site to gather preliminary data on effectiveness in improving engagement with MOUD at 10 and 30 days. The findings from the pragmatic phase will be used to refine the EMS protocol before moving toward larger randomized comparisons. Qualitative and refusal-cohort analyses will help understand barriers and inform protocol revisions. The overall aim is to determine whether EMS-initiated buprenorphine can improve linkage to ongoing treatment for opioid use disorder.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18 years of age or older
* Treated by the EMS-Initiated buprenorphine clinical protocol which includes:

Patients that accept EMS-Initiated BUP protocol. Patients offered the EMS-Initiated BUP protocol but declined.1

* Willing to follow study procedures.
* Able to speak English sufficiently to understand study procedures, and to provide verbal and electronic/written consent.

Exclusion Criteria:

* Patients who lack decision making capacity
* Patients who are in police or protective custody

Where it's running

• Alameda Health System
  Oakland, California, United States Recruiting
• Hennepin Healthcare
  Minneapolis, Minnesota, United States Recruiting
• Cooper University Hospital
  Camden, New Jersey, United States Recruiting

Study contacts

• Principal investigator: Gail D'Onofrio, MD, MS — Yale University
• Study coordinator: Gail D'Onofrio, MD, MS
• Email: gail.donofrio@yale.edu
• Phone: 12037857059

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• CBD for Opioid Dependence and Pain on Buprenorphine

  This study tests whether different doses of cannabidiol (CBD) can affect pain and opioid cravings in adults with opioid use disorder who are on buprenorphine, using a short, randomized, placebo-controlled setup.

  Recruiting Early Phase 1 Yale University · West Haven, Connecticut · NCT07886606

• Cebranopadol for opioid withdrawal in adults with chronic pain

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• emPath platform pilot to link and keep adults with opioid use disorder in care in Durham

  This pilot tests a mobile app and telemedicine approach to help adults with opioid use disorder start and stay in MOUD through community outreach in Durham, NC.

  Recruiting Duke University · Durham, North Carolina · NCT07810322

• CB1 Receptors in Opioid Use Disorder Measured with a PET Radioligand

  This study tests CB1 receptor availability in people with opioid use disorder starting opioid agonist therapy and compares them with healthy adults.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT07800520

• STORC: Training a support person plus patient navigation after birth

  We’re testing whether training a designated support person and using patient navigation after delivery helps people with opioid use disorder build recovery resources and stay in treatment.

  Recruiting Friends Research Institute, Inc. · Philadelphia, Pennsylvania · NCT07787039

• Personalized Addiction Treatment Enhancement for Opioid Use Disorder

  A digital platform run by peer recovery supporters will be tested to help adults with opioid use disorder who are on buprenorphine or methadone stay in treatment and improve outcomes.

  Recruiting Rhode Island Hospital · Providence, Rhode Island · NCT07778394

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.