Biomarkers for opioid use and pain response after trauma and surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will examine miRNA expression dynamics in patients treated with opioids following traumatic injury or surgical procedures. Researchers will collect behavioral data and genomic information to see if miRNA signatures can better predict persistent opioid use and pain outcomes than current tools. The goal is to develop a scalable screening approach to identify individuals at higher risk for opioid use disorder after prescription opioid use. The work follows Wellcome Leap goals to quantify addiction risk and progression during pain management. No interventions are being tested in this study; the focus is on biomarker discovery and feasibility.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients 18 years of age or older
* Patients admitted for traumatic injury at Hillcrest or Jacobs Medical Center or patients who will undergo the orthopedic (e.g., joint, spine), abdominal, breast, vascular (e.g., amputation), or thoracic surgery.

Exclusion Criteria:

* Patients with a prior history of opioid use disorder or dependence
* Pregnant women
* Prisoners
* Patients with an inability to independently provide informed consent to participate in the study due to lack of capacity. This lack of capacity can be from either a chronic/continuous condition (i.e. dementia), or can be temporary (i.e. clear signs of intoxication at the time of the visit (not alert or oriented, slurring words \[and confirmed not to be baseline\], unsteady gait \[and confirmed not to be baseline\], or appears impaired based on clinical judgement by PI/Co-I)).

Where it's running

• University of California, San Diego
  La Jolla, California, United States Recruiting

Study contacts

• Principal investigator: Rodney A Gabriel — University of California, San Diego
• Study coordinator: Rodney A Gabriel
• Email: ragabriel@health.ucsd.edu
• Phone: 858-663-7747

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.