Canadian Emergency Department Opioid Registry (CEDRN)
Optimizing Outcomes for Patients Presenting to Emergency Departments With Opioid Poisoning
This project will create a national emergency department registry to collect information on people of all ages who come to EDs with suspected or confirmed opioid poisoning to see if those data can guide better care and prevent deaths.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 7200 (estimated) |
| Sex | All |
| Sponsor | University of British Columbia Academic / other |
| Locations | 1 site (Vancouver, British Columbia) |
| Trial ID | NCT07466784 on ClinicalTrials.gov |
What this trial studies
The CEDRN Opioid Registry will use automated screening of electronic health records at participating emergency departments to identify consecutive patients with suspected or confirmed opioid poisoning, opioid withdrawal, or related diagnoses. Sites will harmonize data collection on patient demographics, presentation details, ED and in-hospital treatments (including naloxone and opioid agonist therapies), and short-term clinical outcomes. Data will be aggregated across participating Canadian EDs to characterize care patterns, gaps, and outcomes and to enable timely, practice-informing analyses. The registry is observational and does not change individual patient care but aims to generate high-quality evidence to improve ED responses to the unregulated drug crisis.
Who should consider this trial
Good fit: People of any age who present to a participating Canadian emergency department with suspected or confirmed opioid poisoning, opioid withdrawal, or related opioid-use diagnoses, or who have opioid-related medications or naloxone recorded in recent visits, are the intended participants.
Not a fit: People who do not present to participating EDs, those with only non-opioid overdoses, or individuals treated entirely outside hospital settings are unlikely to receive direct benefit from this registry.
Why it matters
Potential benefit: If successful, the registry could identify effective ED practices and gaps, helping to speed adoption of life-saving treatments and improve links to harm reduction and addiction care to reduce opioid-related deaths.
How similar studies have performed: Regional ED and overdose surveillance systems have provided useful public-health insights, but a harmonized pan-Canadian emergency-department opioid registry at this scale is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. All patients who arrive at the emergency department with the following emergency department discharge diagnosis: * Percocet Overdose * Oxycontin Overdose * Oxycodone Overdose * Opioid Overdose or Intoxication * Methadone Overdose * Heroin Overdose * Fentanyl Overdose * Codeine Overdose * Carfentanil Overdose * Opioid Withdrawal 2. All patients who arrive at the emergency department who had the following medication ordered in the present visit or previous hospital visits in the past 2 years: * Buprenorphine * Buprenorphine-naloxone * Methadone - Past ED or IP encounter * Kadian/Morphine long-acting * Naloxone * Naloxone kit 3. All patients who arrive at the emergency department with the following impatient discharge diagnosis: * Opioid use disorder (mild/moderate/severe, abuse/dependence), or opioid-related disorders * Adverse effect, and poisoning by polysubstance use * Opioid intoxication or withdrawal * Intoxication or withdrawal (from any substance, including unspecified ones) * Adverse effect, and poisoning by opioids, benzodiazepines, other antiepileptic and sedative-hypnotic drugs, and unspecified drugs * Any psychoactive substance abuse resulting in intoxication, withdrawal, or any adverse effects
Where this trial is running
Vancouver, British Columbia
- Vancouver General Hospital — Vancouver, British Columbia, Canada (Recruiting)
Study contacts
- Principal investigator: Corinne M Hohl, MD, MPH — University of British Columbia
- Study coordinator: Jeffrey P Hau, MSc
- Email: jeffrey.hau@ubc.ca
- Phone: 16048754111
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.