Optimizing long-acting PrEP and opioid treatment for people in jails and prisons

Who could benefit from this research

What this research studies

People in correctional settings face high HIV risk and opioid use disorders. The study will create and test a delivery protocol for long-acting injectable PrEP plus long-acting buprenorphine, and compare it with the standard oral PrEP and sublingual buprenorphine. It uses a hybrid implementation-effectiveness design to see how well the approach works in prison and after release in Maryland and Washington, DC. The goal is to find scalable practices that keep people engaged in treatment and reduce HIV risk and opioid-related harms. Researchers will measure how easily clinics can implement the approach and whether outcomes improve compared with current care.

Why it matters

Where this research is happening

• Duke University
  Durham, United States Active

Researchers

• Principal investigator: Brinkley-Rubinstein, Lauren — Duke University
• Study coordinator: Brinkley-Rubinstein, Lauren

Related research

Other NIH-funded projects on the same topics.

• Systems analysis to improve opioid use disorder care after jail release (SAIA-MOUD)

  A program to help people with opioid use disorder get better, faster, and safer care after they leave jail.

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• Precise epigenetic drugs for opioid addiction

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  NIH research Boston Interactome, INC. · Boston, United States · NIH-11578588

• Increasing Access to Medications for Opioid Use Disorder for Unhoused Montanans

  This project helps unhoused people in Montana get life-saving medicines for opioid use disorder through clinics connected to syringe service programs, a nurse-led MOUD model, and peer support.

  NIH research Open Aid Alliance · Missoula, United States · NIH-11578581

• Scaling up medications for opioid use disorder in residential treatment programs

  This grant studies how to help residential treatment programs provide medications for opioid use disorder to reduce overdoses after discharge, focusing on real-world settings and policies.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11535207

• Increasing Capacity at a Native Community Clinic to Improve Opioid Care for urban AI/AN

  This grant helps a Native American health clinic build its research capacity to better serve urban American Indian and Alaska Native people dealing with opioid use disorder and related health issues.

  NIH research Native American Community Clinic · Minneapolis, United States · NIH-11533803

• Multimodal fetal and placental imaging to predict outcomes in infants exposed to opioids

  This project uses brain and placenta imaging plus biomarkers to understand how prenatal opioid exposure affects babies and how to predict and improve outcomes for infants born to mothers with opioid use disorder.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11518816

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.