Peer-led harm reduction intervention for opioid use disorder in hospitals

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to develop and evaluate the THRIVE intervention, a peer-led bundle of harm reduction services designed for delivery in hospital settings. Participants will receive in-person sessions from peer support specialists, along with weekly text messages for 12 weeks and periodic assessments. The study will compare the effectiveness of the THRIVE intervention against enhanced usual care in reducing self-reported non-fatal overdoses and skin/soft tissue infections among individuals with opioid use disorder. The goal is to determine if this peer support approach can significantly improve patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants who are: a) admitted to University of Pittsburgh Medical Center (UPMC) Shadyside Hospital, UPMC Presbyterian-Montefiore Hospital, UPMC Mercy Hospital for inpatient or observation status, or b) seen in the Emergency Department setting at UPMC Presbyterian-Montefiore Hospital and UPMC Mercy Hospital.
* Participants must have a current diagnosis of Opioid Use Disorder based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) diagnostic criteria.
* Participants must be at least 18 years of age on day of admission.
* Participants must be able to speak and read English.

Exclusion Criteria:

* Participants diagnosed with dementia and/or cognitive impairments.
* Participants with acute psychiatric complications, such as schizophrenia with acute psychosis, acute mania, or suicidal ideation (which may impact the ability of a participant to consent and actively participate in treatment).
* Participants who are pregnant or lactating at onset of study.
* Participants who cannot read or speak English.

Where it's running

• UPMC Presbyterian-Montefiore Hospital
  Pittsburgh, Pennsylvania, United States Recruiting
• UPMC Mercy Hospital
  Pittsburgh, Pennsylvania, United States Not yet recruiting
• UPMC Shadyside Hospital
  Pittsburgh, Pennsylvania, United States Not yet recruiting

Study contacts

• Principal investigator: Jacqueline D Wilson, MD — University of Pennsylvania
• Study coordinator: Research Program Coordinator
• Email: thriving@pitt.edu
• Phone: 412-679-9848

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Clinical Decision Support to Help Treat Opioid Use Disorder

  Aimed at primary care patients using opioids, this study tests a CDS alert and a care pathway to help doctors identify and treat opioid use disorder with approved medications.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT06526286

• CBD for Opioid Dependence and Pain on Buprenorphine

  This study tests whether different doses of cannabidiol (CBD) can affect pain and opioid cravings in adults with opioid use disorder who are on buprenorphine, using a short, randomized, placebo-controlled setup.

  Recruiting Early Phase 1 Yale University · West Haven, Connecticut · NCT07886606

• Cebranopadol for opioid withdrawal in adults with chronic pain

  This study tests whether cebranopadol can reduce withdrawal symptoms in adults with chronic pain who are physically dependent on prescribed opioids, compared with placebo.

  Recruiting at 2 sites Phase 2 Adneuris Therapeutics, Inc. · North Canton, Ohio and 1 other locations · NCT07874620

• emPath platform pilot to link and keep adults with opioid use disorder in care in Durham

  This pilot tests a mobile app and telemedicine approach to help adults with opioid use disorder start and stay in MOUD through community outreach in Durham, NC.

  Recruiting Duke University · Durham, North Carolina · NCT07810322

• CB1 Receptors in Opioid Use Disorder Measured with a PET Radioligand

  This study tests CB1 receptor availability in people with opioid use disorder starting opioid agonist therapy and compares them with healthy adults.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT07800520

• STORC: Training a support person plus patient navigation after birth

  We’re testing whether training a designated support person and using patient navigation after delivery helps people with opioid use disorder build recovery resources and stay in treatment.

  Recruiting Friends Research Institute, Inc. · Philadelphia, Pennsylvania · NCT07787039

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.