Women-focused overdose prevention during jail-to-community re-entry in Kentucky

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase II trial uses a randomized, factorial design to compare different pre-release and post-release components of the Overdose Prevention Intervention Package (OPIP) for women re-entering rural communities. Participants are opioid and/or stimulant use disorder positive, preparing for release within 7–60 days, and willing to engage in post-release treatment. The design examines pre-release strategies (Recovery Coaching alone vs. Recovery Coaching with a support person) and post-release strategies (continuation vs. addition of contingency management) to reduce overdose risk and enhance treatment entry and retention. The study involves multiple rural Kentucky sites and is led in collaboration with NIDA, aiming to inform scalable, sustainable approaches for mitigating overdose during re-entry. The intervention focuses on creating an overdose prevention plan and supporting treatment engagement during the critical transition period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* DSM-5 scores of 2+ for opioids (OUD) and/or stimulants (StUD),
* no evidence of cognitive impairment in providing consent,
* a release date within 7-60 days to allow for time for intervention sessions,
* willingness to consider SUD treatment post-release, and
* willingness to provide the name and contact information of at least one person in the community who will support the woman's recovery pre/post-release (SP).

Exclusion Criteria:

* Not living in a rural area
* Any condition that would not allow capable informed consent

Where it's running

• Knox County Detention Center
  Barbourville, Kentucky, United States Recruiting
• Harlan County Detention Center
  Harlan, Kentucky, United States Recruiting
• Leslie County Detention Center
  Hyden, Kentucky, United States Recruiting

Study contacts

• Principal investigator: Michele Staton, PhD — University of Kentucky
• Study coordinator: Michele Staton, PhD
• Email: mstaton@uky.edu
• Phone: 859-312-8245

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.