Social functioning and recovery for people with opioid use disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-arm study will enroll 100 patient–concerned significant other (CSO) pairs, focusing on adults with current opioid use disorder who started buprenorphine within the past four weeks and receive care at participating Charleston clinics. Participants will complete ecological momentary assessments (EMA) via brief daily surveys while wearing a smartwatch app (SocialBit) that passively captures affiliative social engagement and social reward–related signals. The study combines patient self-reports, CSO reports, and passive smartwatch metrics alongside a CBT4CBT behavioral intervention to track how social functioning changes and which metrics predict better treatment trajectories. Results aim to clarify modifiable social targets that could be used to personalize behavioral supports in buprenorphine-based care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Any sex or gender; any race or ethnicity; aged 18 years or older
* Patient participants must meet DSM-5 diagnostic criteria for current (i.e., past 12 months) OUD (assessed via the Quick Structured Clinical Interview for DSM-5; Quick SCID)
* Patient participants must be on medication for opioid use disorder (MOUD), as prescribed by their provider, for no more than 12 weeks prior to study initiation
* Patient participants must be in treatment at a clinic in South Carolina
* Concurrent substance use disorders (e.g., alcohol, cannabis) for the patient participant are acceptable, provided opioids are the patient participant's primary substance of choice
* Patient participants must identify a CSO participant who consents to participation in the study as well

Exclusion Criteria:

* Moderate-to-severe opioid withdrawal as defined by a score of ≥21 on the Subjective Opioid Withdrawal Scale
* Meeting DSM-5 criteria for a history of or current psychotic or bipolar disorders
* Current suicidal or homicidal ideation and intent; participants who present a serious suicide risk are likely to require hospitalization during the study and they will be referred clinically
* CSO participants meeting DSM-5 criteria for opioid use disorder or any other substance use disorder, excepting tobacco use disorder, mild cannabis use disorder, and mild alcohol use disorder
* Severe interpersonal violence in the past six months between the patient and the CSO, as defined by an adapted version of the Conflict Tactics Scaled Revised (CTS-2)
* Pregnancy for patient participants
* Prisoners, institutional individuals, and children will not be recruited for this study.

Where it's running

• Medical University of South Carolina
  Charleston, South Carolina, United States Recruiting

Study contacts

• Principal investigator: Amber M Jarnecke, PhD — Medical University of South Carolina
• Study coordinator: Amber Anderson, BA
• Email: anderamb@musc.edu
• Phone: 843-876-3115

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• emPath platform pilot to link and keep adults with opioid use disorder in care in Durham

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• STORC: Training a support person plus patient navigation after birth

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• Personalized Addiction Treatment Enhancement for Opioid Use Disorder

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.