Examining brain function and memory in relation to opioid use and childhood experiences

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how adverse childhood experiences affect brain function and memory in adults with Opioid Use Disorder (OUD) compared to healthy individuals. Participants will undergo Magnetic Resonance Imaging (MRI) and perform computer tasks to assess their learning and memory capabilities. The study includes three groups: those with OUD on buprenorphine, those without OUD also on buprenorphine, and healthy adults not on buprenorphine. The goal is to understand the relationship between childhood adversity and opioid use through brain performance metrics.

Why it matters

Who can join: the full rules

Inclusion Criteria for all groups:

* Fluent in English
* Able to give informed consent
* Normal/corrected-to-normal vision and hearing

Inclusion Criteria for Opioid Use Disorder (OUD) group:

* Diagnosis of OUD
* Be actively receiving buprenorphine (BUP) for opioid agonist therapy
* Be free from illicit substance use for at least 2 weeks
* The study will allow stable dose (\> 3 months) of commonly prescribed psychiatric medications and some sleep aids (per protocol)

Inclusion Criteria for the BUP control group:

* Taking BUP for chronic pain
* No Substance Use Disorder (including OUD)
* The study will allow stable dose (\> 3 months) of commonly prescribed psychiatric medications and some sleep aids (per protocol)

Inclusion Criteria for Healthy participant group:

* Not taking BUP
* Free of any psychiatric or major medical conditions

Exclusion Criteria for all groups:

* Pregnancy
* Significant medical or neurologic conditions (e.g., stroke, seizures, multiple sclerosis)
* Actively suicidal
* Contraindication for MRI
* Inability to tolerate small, enclosed spaces without anxiety or unable to fit comfortably in the MRI scanner
* Life history of schizophrenia, learning disability, attention deficit disorder, or pervasive developmental disorder
* Use of substances or prescription medications that could interfere with measures of interest (per protocol)
* Unable to provide informed consent
* Participants who have completed other studies in our lab involving learning and memory assessments with the same/similar tasks used here (HUM00230585, HUM00121812) will not be eligible to complete the current study, due to possible learning/practice effects

Where it's running

• University of Michigan
  Ann Arbor, Michigan, United States Recruiting

Study contacts

• Principal investigator: Elizabeth Duval — University of Michigan
• Study coordinator: Aml Almamri
• Email: AdversityBrainOUD@med.umich.edu
• Phone: 734-232-0190

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• emPath platform pilot to link and keep adults with opioid use disorder in care in Durham

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• Personalized Addiction Treatment Enhancement for Opioid Use Disorder

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.