Condition

Opioid Dependence clinical trials and research

• 9Clinical trials
• 3Countries

Newest Opioid Dependence clinical trials

All recruiting trials (9)

• Mild electrical brain stimulation (tDCS) with cognitive training to reduce cocaine cravings.

  This trial will test whether brief sessions of mild electrical brain stimulation (tDCS) combined with cognitive reappraisal training can lower craving in adults receiving inpatient treatment for cocaine use disorder.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT07318480

• Using buprenorphine for pain relief after ankle fracture surgery

  This study tests if a skin patch with buprenorphine can help manage pain after ankle fracture surgery for patients who haven't used opioids before, while also looking at safety and the risk of addiction.

  Recruiting Phase 4 Washington University School of Medicine · St Louis, Missouri · NCT06949826

• Examining brain activity patterns related to opioid relapse during treatment

  This study is testing how brain activity patterns might predict the risk of relapse to opioid use in people who have just started treatment with methadone or buprenorphine.

  Recruiting at 2 sites Yale University · Hartford, Connecticut and 1 other locations · NCT06651333

• Safer pain treatment options for cancer survivors on long-term opioids

  This project will try four different approaches to lower long-term opioid use while keeping pain controlled in Veterans who are cancer survivors on chronic opioid therapy.

  Recruiting Phase 4 VA Office of Research and Development · Indianapolis, Indiana and 1 other locations · NCT06574009

• Evaluating the effects of suvorexant on drug demand in people with opioid use disorder

  This study is testing if the sleep medication suvorexant can help people with opioid use disorder reduce their cravings for drugs.

  Recruiting Early Phase 1 University of Maryland, Baltimore · Baltimore, Maryland · NCT05829655

• Assessing the safety and pharmacokinetics of IVL3004 and IVL4002 in healthy males

  This study is testing two new drugs, IVL3004 and IVL4002, in healthy men to see how safe they are and how the body absorbs them compared to an existing treatment for addiction.

  Recruiting Phase 1 Inventage Lab., Inc. · Herston, Queensland · NCT05620940

• Psilocybin-assisted psychotherapy to help taper long-term opioid pain medicines

  This pilot will try psilocybin-assisted psychotherapy to help adults with chronic noncancer pain who are on long-term opioid therapy reduce or stop their opioid medications.

  Recruiting Phase 2 University of British Columbia · Kelowna, British Columbia · NCT05585229

• Community-based program for youth with opioid use disorder

  This study is testing a community program that helps young people with opioid use disorder get better treatment and support to see if it keeps them engaged in recovery and reduces overdoses.

  Recruiting Phase 4 The University of Texas Health Science Center, Houston · Houston, Texas · NCT04811014

• Program to reduce opioid use in chronic pain patients after surgery

  This study is testing a new program to help chronic pain patients use less opioids after surgery by providing pain education and support tools.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT03675386

Related topics

Quick answers

How many Opioid Dependence clinical trials are recruiting right now?

9, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (6 trials), Canada (2 trials), Australia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 3, Early Phase 1: 1, Phase 2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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