Condition

Alcohol Use clinical trials and research

• 16Clinical trials
• 548NIH research projects
• 2Countries

Newest Alcohol Use clinical trials

All recruiting trials (16)

• Smartphone-based Intervention for Young Adults with ADHD and Risky Drinking

  A smartphone-based program is tested to see if it's doable and helpful for young adults with ADHD who also drink at risky levels.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07654205

• Postpartum mood and alcohol use: a CM-PST approach for new mothers

  This study tests whether a six-week CM-PST program helps reduce depressive symptoms and alcohol use in new mothers within the first year after birth.

  Recruiting University of Illinois Chicago · Chicago, Illinois · NCT07485036

• Mindfulness Relapse Prevention for Smoking and Alcohol in Cancer Survivors

  This study tests whether Mindfulness-Based Relapse Prevention for Smoking and Alcohol (MBRP-SA) helps cancer survivors quit smoking and reduce risky drinking compared with standard care.

  Recruiting H. Lee Moffitt Cancer Center and Research Institute · Tampa, Florida · NCT07447635

• Proactive Automatized Lifestyle Intervention for Multiple Health Risk Behaviors

  This trial tests a proactive, automated program to help hospital patients reduce tobacco and alcohol use, eat better, and exercise more.

  Recruiting University Medicine Greifswald · Greifswald · NCT07441603

• Brief alcohol-focused program tailored for people taking buprenorphine

  This project will try a short, opioid-informed alcohol counseling program for adults on prescribed buprenorphine who drink alcohol to see if it reduces drinking and helps them stay in treatment.

  Recruiting University of Notre Dame · Notre Dame, Indiana · NCT07342504

• College student strategies to reduce alcohol-related harm

  This trial will test whether adding personalized goal-setting helps college students who drink weekly use protective behavioral strategies more and cut down on risky drinking and harms.

  Recruiting University of Wyoming · Laramie, Wyoming · NCT07156305

• Get Better Together weekend for military couples

  This program tests whether a weekend Get Better Together retreat helps military couples improve relationship skills and mental health and reduce problems like alcohol misuse, aggression, and suicide risk.

  Recruiting Henry M. Jackson Foundation for the Advancement of Military Medicine · Bethesda, Maryland · NCT07096271

• Intervention for heavy drinking in young adults

  This study tests a new program that helps young adults aged 18-25 who drink heavily by using online counseling and mobile tools to encourage them to drink less.

  Recruiting Northeastern University · Boston, Massachusetts · NCT06994962

• Mindfulness relapse prevention that tracks heart rate and mood for people with alcohol problems.

  This program tests whether an 8-week mindfulness-based relapse prevention course plus wearable heart-rate sensors and three daily surveys can reduce drinking and improve self-regulation in adults with moderate to severe alcohol use disorder.

  Recruiting University of New Mexico · Albuquerque, New Mexico · NCT06982443

• Rest-Up: brief programs to reduce heavy drinking and cannabis use and improve sleep in young adults

  This program will test short, integrated behavioral sessions to reduce heavy drinking and cannabis use and improve sleep in 18–29-year-olds with sleep problems who live in Washington State.

  Recruiting University of Washington · Seattle, Washington · NCT06736444

• Evaluating caregiver involvement in interventions for adolescent alcohol use problems

  This study tests how different levels of caregiver involvement can help teenagers with mild alcohol problems reduce their drinking and improve their overall well-being.

  Recruiting Indiana University · Indianapolis, Indiana · NCT06593652

• MATAspire: A Web App to Help CSUN Students Prevent Substance Misuse

  A web-app tests a six-week program to help CSUN students build coping skills and reduce use of alcohol, cannabis, nicotine, illicit drugs, and prescription opioid misuse.

  Recruiting California State University, Northridge · Northridge, California · NCT06553196

• Exploring resilience in Black adults facing substance misuse

  This study is trying to see how daily stress and experiences of racism affect substance use in Black young adults and what coping strategies can help them manage these challenges.

  Recruiting at 2 sites University of Washington · Dallas, Texas and 1 other locations · NCT06457841

• Psychedelic DMT for Alcohol Use Disorder

  This trial will test whether a single psychedelic dose of DMT plus a short course of psychotherapy helps people with Alcohol Use Disorder drink less.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT06070649

• Reducing alcohol use among people living with HIV using mobile health tools

  This study is testing if using mobile health tools can help people living with HIV cut down on their alcohol use.

  Recruiting at 2 sites University of Florida · Coral Gables, Florida and 1 other locations · NCT05153811

• Evaluating guanfacine's effects on drinking behavior in individuals with alcohol use disorders

  This study is testing if the medication guanfacine can help adults with alcohol use disorders drink less, while also looking at any differences between men and women.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT03764098

NIH-funded research (newest 40 of 548)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Biomarkers to detect recent heavy drinking in veterans

  A doctor-scientist team is testing blood biomarkers to better identify recent excessive alcohol use in veterans so clinicians can screen, counsel, and care for those at risk.

  NIH research Rlr VA Medical Center · Indianapolis, United States · NIH-11685217

• Understanding how heavy drinking and anxiety relate in emerging adults

  This grant studies how heavy alcohol use and anxiety symptoms interact in young adults (ages 18–34) and what biological stress markers might reveal about that relationship.

  NIH research Brown University · Providence, United States · NIH-11627893

• Understanding how veterans access care for alcohol use and behavioral health

  A study following 2,000 post-9/11 veterans to see how alcohol use, PTSD, and depression relate to access to behavioral health care over four years.

  NIH research Washington University · Saint Louis, United States · NIH-11617899

• Understanding how peer norms around alcohol and HIV prevention affect adolescents and young adults in rural Uganda

  This project studies how what young people think their peers do or approve of influences drinking and HIV prevention behaviors in rural Uganda, with the goal of improving health outcomes.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11616487

• Mentor Moms+: a community-led plan to cut alcohol use and HIV risk during pregnancy in South Africa

  A community-based program adapts a trusted peer-led model to help pregnant and lactating people reduce alcohol use and HIV risk in South Africa.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11612340

• Functional Connectivity-Guided TMS for Alcohol Use Disorder

  A new approach uses targeted brain stimulation to help people with alcohol use disorder stay abstinent longer by focusing treatment on specific brain circuits.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11601597

• Alcohol Use Disorder and Suicidal Behavior: Finding Why They Occur Together

  A study using Swedish population data to understand why alcohol use disorder relates to suicidal thoughts and acts, with the goal of improving risk prediction and prevention.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11601596

• Non-hallucinogenic psilocybin derivative for alcohol use disorder

  A new, safer psilocybin-like compound is being studied to help people with alcohol use disorder.

  NIH research Terp Life, LLC · Tampa, United States · NIH-11594445

• Reducing hazardous drinking and improving HIV care for men with HIV in fishing communities

  A behavioral program helps men with HIV in Lake Victoria’s fishing communities drink less and stick to HIV treatment, aiming for better health outcomes.

  NIH research San Diego State University · San Diego, United States · NIH-11593929

• Alcohol use and suicidal thoughts: how decision-making affects risk

  This project looks at how acute alcohol use and people’s decision-making patterns relate to suicidal thoughts and behaviors in adults.

  NIH research University of Kentucky · Lexington, United States · NIH-11592176

• Identifying brain proteins linked to PTSD and alcohol use disorder

  Researchers are studying brain proteins that may contribute to PTSD and alcohol use disorder in US veterans to find new ways to help people who struggle with both conditions.

  NIH research VA Northern California Health Care Sys · Mather, United States · NIH-11578051

• A brief alcohol support for PrEP users to boost HIV prevention

  A short, friendly program helps people starting or restarting PrEP in Vietnam drink less and stick with PrEP to stay protected.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11574743

• Mu and Kappa Opioid Balance in Alcohol Use Disorder

  A study using brain imaging to understand how the brain’s opioid system changes during early sobriety in adults with alcohol use disorder.

  NIH research Yale University · New Haven, United States · NIH-11564204

• CONNECT-A: A multi-component plan to reduce HIV risk by addressing alcohol use and mental health and economic stress in young men

  A community-based program helps high-risk young men reduce unhealthy drinking, improve PrEP use, and tackle stress and mental health barriers to HIV prevention.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11537067

• Improving treatment for people with HIV who smoke and drink in Nairobi, Kenya

  A study tests a new plan to help people with HIV in Nairobi quit smoking and reduce heavy drinking, using a low-cost medicine and counseling.

  NIH research University of Chicago · Chicago, United States · NIH-11535379

• Alcohol use patterns, aging, and health in people with HIV

  This grant looks at how unhealthy drinking affects aging and health problems in people living with HIV and how alcohol care might help them stay healthier longer.

  NIH research University of Washington · Seattle, United States · NIH-11534434

• A combined motivational interviewing and behavioral couples therapy to reduce IPV and alcohol use in South India

  A program that blends motivational interviewing with behavioral couples therapy to help reduce intimate partner violence and alcohol use among couples in South India.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11531393

• Telehealth support to prevent suicide in people with alcohol use disorder in Tanzania

  A telehealth counseling program is being adapted to help reduce suicide risk for people with alcohol use disorder in emergency departments in Tanzania.

  NIH research Duke University · Durham, United States · NIH-11519492

• Neural targets for improving function in Veterans with alcohol use disorder and mild brain injury

  This project tests a targeted brain-stimulation approach to help Veterans who have both alcohol use problems and mild traumatic brain injury improve daily functioning.

  NIH research Edward Hines Jr VA Hospital · Hines, United States · NIH-11518051

• Economic and relationship support to help couples in Malawi reduce heavy drinking

  This program offers HIV-affected couples in Malawi combined financial coaching and relationship skills to help men drink less and support HIV treatment adherence.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11504799

• Treating Alcohol Use Disorder in Primary Care with Semaglutide

  This grant tests whether the diabetes drug semaglutide can help adults reduce or stop drinking when used in primary care.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11491479

• Combined motivational interviewing with real-time prompts to cut risky drinking in young adults at high HIV risk

  A 3-arm study tests whether remote motivational interviewing alone or with real-time GPS-triggered messages can help 18+-year-olds at high HIV risk drink less and reduce risky behaviors.

  NIH research Yale University · New Haven, United States · NIH-11482052

• Systematic Patient-centered Care for Alcohol Use Disorder in Primary Care

  A pragmatic study in Kaiser Permanente primary care clinics tests two ways to help patients with alcohol use disorder use shared decision-making to start treatment and reduce drinking.

  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-11481373

• Combined peer support and online program to help HIV prevention for youths

  A youth-focused program combines a web-based alcohol/sexual risk intervention with peer counseling and navigation to reduce HIV risk and alcohol use.

  NIH research Northeastern University · Boston, United States · NIH-11474091

• Multilevel alcohol use and HIV risk among young men

  A short, plain-English look at how drinking patterns among young men relate to HIV risk, studied in Chicago.

  NIH research Northwestern University · Chicago, United States · NIH-11470969

• Real-World Use of doxy-PEP for STI Prevention in HIV+ individuals, considering alcohol use and gut health

  A real-world study will track how well doxycycline post-exposure prophylaxis works to prevent STIs in men with HIV who have sex with men, especially when alcohol use and gut inflammation are involved.

  NIH research University of Florida · Gainesville, United States · NIH-11470392

• Microglia as targets to reduce negative mood in alcohol use disorder

  This grant explores how brain immune cells called microglia contribute to negative feelings in people with alcohol use disorder and tests ways to calm them to improve mood.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11465406

• Physical activity program to help pregnant women cut back on drinking

  A prenatal program uses movement and activity to help pregnant women who drink reduce alcohol use and improve outcomes for mom and baby.

  NIH research Butler Hospital (Providence, Ri) · Providence, United States · NIH-11455105

• Augmented Reality app to help Veterans with Alcohol Use Disorder

  A smartphone AR app is being developed to support veterans with alcohol use disorder through cue-based, technology-enabled therapy.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11451985

• Population-level alcohol screening and support for cancer patients to reduce secondary cancer risk

  A large study will test a practical program in cancer care to screen for hazardous drinking and connect patients to help, aiming to lower the chance of cancer coming back or new cancers.

  NIH research University of Kentucky · Lexington, United States · NIH-11449016

• Integrated digital health approach to help rural adults reduce hazardous drinking and chronic pain

  A digital health program designed for adults in rural areas to reduce risky alcohol use while also addressing chronic pain through a streamlined, at-home approach.

  NIH research Boston University (Charles River Campus) · Boston, United States · NIH-11447623

• Psilocybin and brain stimulation to treat alcohol use disorder

  A Johns Hopkins research team is testing whether a combination of psilocybin and customized brain stimulation can reduce cravings and drinking in adults with alcohol use disorder.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11446309

• Understanding how alcohol affects pain in people with alcohol use disorder and chronic pain

  This study tests how alcohol changes pain sensitivity in adults with alcohol use disorder and chronic pain using a controlled IV alcohol setup.

  NIH research Yale University · New Haven, United States · NIH-11444910

• LIFT Clinic: Post-Transplant Alcohol Care Pilot

  A patient-centered plan to help people who had a liver transplant stay abstinent from alcohol, using structured monitoring and coordinated care.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11442475

• Making alcohol help fit into cancer care

  A cancer care program is testing ways to help patients reduce alcohol use by using simple screening and follow-through plans inside their treatment teams.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11440656

• Alcohol Use Disorder Care in Primary Care: Making Treatment Easier and More Effective

  A primary care-based program helps people with alcohol use disorder get evidence-based medications and support over 12 weeks to improve drinking outcomes.

  NIH research Veterans Health Research Institute of Central New York, INC. · Syracuse, United States · NIH-11438214

• Reducing cardiovascular risk by stopping alcohol use

  A major NIIH-funded trial will test whether abstaining from alcohol improves heart and blood vessel health in adults who drink more than recommended.

  NIH research University of Texas Arlington · Arlington, United States · NIH-11432868

• N-acetylcysteine to rebalance brain chemistry and reduce heavy drinking in bipolar disorder with alcohol use

  This project tests a safe medication, N-acetylcysteine, to help people with bipolar disorder who drink heavily by stabilizing brain chemistry and reducing drinking.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11430386

• Evidence-based alcohol and sexual risk support in homeless young adults

  A real-world study will bring a proven counseling approach to drop-in centers serving 18–25-year-olds who are homeless, to help reduce alcohol use and risky sexual behaviors.

  NIH research Rand Corporation · Santa Monica, United States · NIH-11430370

• Stigma and alcohol use across women and their children

  This project looks at how stigma around women’s drinking affects mothers and their children over time.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11423727

Related topics

Quick answers

How many Alcohol Use clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (15 trials), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →