Condition
Harm Reduction clinical trials and research
As of November 12, 2026, Find a Trial lists 6 Harm Reduction clinical trials that are recruiting, in United States. By phase: Phase 3 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 6Clinical trials
- 1Country
Newest Harm Reduction clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Reducing overdose and other harms in NYC single-adult shelters | — | New York, New York | Recruiting | Sep 12, 2025 |
| Peer-led harm reduction intervention for opioid use disorder in hospitals | — | Pittsburgh, Pennsylvania and 2 other locations | Recruiting | Feb 24, 2025 |
| Digital harm reduction treatment for alcohol use disorder | Phase 3 | Seattle, Washington | Recruiting | Nov 22, 2024 |
| Clinical Decision Support to Help Treat Opioid Use Disorder | — | Aurora, Colorado | Recruiting | Jul 29, 2024 |
| Evaluating e-cigarettes and nicotine pouches for smokers | — | Philadelphia, Pennsylvania | Recruiting | Apr 18, 2024 |
| A program to educate and support middle and high school students about substance use | — | Boston, Massachusetts | Recruiting | Nov 3, 2023 |
All recruiting trials (6)
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Reducing overdose and other harms in NYC single-adult shelters
This project will use linked city records and interviews to see if harm-reduction efforts in NYC single-adult shelters reduce overdoses and other health harms among adults who use drugs.
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Peer-led harm reduction intervention for opioid use disorder in hospitals
This study is testing a new peer support program in hospitals to see if it can help people with opioid use disorder have fewer overdoses and infections compared to regular care.
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Digital harm reduction treatment for alcohol use disorder
This study is testing a new online treatment for alcohol use disorder to see if it helps people who have been homeless and are now in supportive housing feel better and reduce alcohol-related problems compared to regular services.
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Clinical Decision Support to Help Treat Opioid Use Disorder
Aimed at primary care patients using opioids, this study tests a CDS alert and a care pathway to help doctors identify and treat opioid use disorder with approved medications.
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Evaluating e-cigarettes and nicotine pouches for smokers
This study is testing whether e-cigarettes or nicotine pouches can help long-term smokers quit regular cigarettes and reduce their smoking habits over six weeks.
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A program to educate and support middle and high school students about substance use
This study is testing a new drug education program for middle and high school students who have broken school rules about substance use to see if it helps them make better choices about drugs.
Related topics
Quick answers
How many Harm Reduction clinical trials are recruiting right now?
6, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
All of them have sites in United States. Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.