Resilience in people with opioid use disorder
A Novel Human Laboratory Model of Resilience Among Individuals With Opioid Use Disorder
This project will test whether short lab tasks performed during stress and non‑stress sessions match up with self‑rated resilience in adults with opioid use disorder.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 125 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Johns Hopkins University Academic / other |
| Locations | 2 sites (Baltimore, Maryland and 1 other locations) |
| Trial ID | NCT06954402 on ClinicalTrials.gov |
What this trial studies
This outpatient, within‑subject randomized study has participants complete two experimental sessions in random order: one using an acute stress induction and one using a non‑stress control. In each session participants perform standardized tasks designed to probe cognitive, emotional, and control aspects of resilience while researchers collect task performance, physiological measures, and self‑reported stress responses. The goal is to develop and validate a laboratory model that links objective behaviors and physiology to subjective resilience in people with OUD. Sessions occur at a single clinical site and use established stress paradigms adapted for this population.
Who should consider this trial
Good fit: Adults (18+) who meet DSM‑5 criteria for current opioid use disorder or are receiving OUD pharmacotherapy, can give informed consent, and have a urine test positive for opioids are ideal candidates.
Not a fit: People who are pregnant or breastfeeding, have unstable serious psychiatric or medical conditions that interfere with participation, or are not currently using opioids are unlikely to gain benefit from participation.
Why it matters
Potential benefit: If successful, the approach could provide objective measures of resilience that help identify who is at higher risk of stress‑related relapse and guide tailored interventions.
How similar studies have performed: Related laboratory stress paradigms have been used successfully in addiction and psychiatric research to link stress reactivity to clinical outcomes, but applying them specifically to model resilience in OUD is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Can provide informed consent and can comply with study procedures 2. Adults aged ≥18 years 3. Meet Diagnostic and Statistical Manual (DSM-5) criteria for current opioid use disorder or are currently receiving pharmacotherapy for the treatment of OUD (e.g. methadone or buprenorphine maintenance treatment \[remission\]) 4. Urine sample that tests positive for opioids 5. Test negative for pregnancy at screening (females only) Exclusion Criteria: 1. Being pregnant or breastfeeding 2. Significant mental health or physical disorder, or life circumstances, that is judged by the investigators to interfere with study participation
Where this trial is running
Baltimore, Maryland and 1 other locations
- Johns Hopkins University Bayview Medical Campus — Baltimore, Maryland, United States (Not_yet_recruiting)
- Johns Hopkins University Bayview Medical Campus — Baltimore, Maryland, United States (Recruiting)
Study contacts
- Principal investigator: Suky Martinez, PhD — Johns Hopkins University
- Study coordinator: Suky Martinez, PhD
- Email: smart209@jh.edu
- Phone: 410-550-0007
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.