Preventing opioid use disorder in homeless youth
Official title: Building Social and Structural Connections for the Prevention of Opioid Use Disorder Among Youth Experiencing Homelessness: An RCT Examining Biopsychosocial Mechanisms
Run by Ohio State University · NCT06311838 · Data updated 2026-11-12
This study is testing different support methods to help homeless youth avoid opioid use and improve their mental health.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 14 Years to 24 Years |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Ohio State University Academic / other |
| Locations | 2 sites (Columbus, Ohio and 1 other locations) |
| Status | Recruiting |
| Started | May 6, 2024 |
| Main results expected | December 1, 2028 |
| Study ends | December 1, 2029 |
| Registry record updated | September 10, 2026 |
| Trial ID | NCT06311838 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are youth aged 14 to 24 who are experiencing homelessness as defined by the McKinney-Vento Act.
✕Probably not a fit
Patients with stable housing situations will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This intervention focuses on youth experiencing homelessness, aiming to prevent opioid use disorder and improve mental health outcomes. It employs a dismantling randomized design to compare various intervention components, including Strengths-Based Outreach and Advocacy and Motivational Interviewing/Community Reinforcement Approach. The study will assess the effectiveness of these interventions in enhancing social stability and psychosocial resources while reducing stress among participants. Additionally, it will explore how demographic factors influence the response to these interventions and evaluate their cost-effectiveness.
Why it matters
Potential benefit: If successful, this intervention could significantly reduce opioid use and improve mental health among homeless youth.
How similar studies have gone: While there is limited research on comprehensive interventions for this population, similar approaches have shown promise in addressing substance use and mental health issues.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Youth must meet the criteria for homelessness as defined by the McKinney-Vento Act: children and youth who lack a fixed, regular, and adequate nighttime residence; or live in a welfare hotel, or place without regular sleeping accommodations, or live in a shared residence with other persons due to the loss of one's housing or economic hardship * Must speak english adequately to complete measures Exclusion Criteria: * Youth who have a stable housing situation. * Non-English speaker
Where it's running
-
Star House
Columbus, Ohio, United States Recruiting -
Ohio State University
Columbus, Ohio, United States Recruiting
Study contacts
- Study coordinator: Jodi Ford, PhD
- Email: ford.553@osu.edu
- Phone: 614-292-6862
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Community partnerships to address the opioid crisis
This study is testing a new online program that helps people recovering from opioid use disorder fix small legal issues that might be holding them back.
-
CBD for Opioid Dependence and Pain on Buprenorphine
This study tests whether different doses of cannabidiol (CBD) can affect pain and opioid cravings in adults with opioid use disorder who are on buprenorphine, using a short, randomized, placebo-controlled setup.
-
Cebranopadol for opioid withdrawal in adults with chronic pain
This study tests whether cebranopadol can reduce withdrawal symptoms in adults with chronic pain who are physically dependent on prescribed opioids, compared with placebo.
-
Virtual Reality to Help Youth in Residential Care Reduce Alcohol and Cannabis Use
This trial tests whether a virtual reality intervention can boost self-confidence to resist drinking and cannabis use among youths in residential care with co-occurring disorders.
-
emPath platform pilot to link and keep adults with opioid use disorder in care in Durham
This pilot tests a mobile app and telemedicine approach to help adults with opioid use disorder start and stay in MOUD through community outreach in Durham, NC.
-
CB1 Receptors in Opioid Use Disorder Measured with a PET Radioligand
This study tests CB1 receptor availability in people with opioid use disorder starting opioid agonist therapy and compares them with healthy adults.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.