Condition

Opioid Use clinical trials and research

• 59Clinical trials
• 534NIH research projects
• 18Countries

Newest Opioid Use clinical trials

All recruiting trials (59)

• Serratus vs Erector Spinae Block for Pain After Unilateral Breast Surgery

  This trial tests whether serratus posterior superior intercostal plane block or erector spinae plane block reduces chronic pain 3 months after unilateral breast surgery in adult women.

  Recruiting Kocaeli City Hospital · İzmit, Kocaeli · NCT07674836

• Using mHealth to Help Black Adults in the Midwest With Opioid/Stimulant Use and Mood Symptoms

  This study tests a mobile health program to support recovery and mood in Black adults who use opioids or stimulants and are seeking treatment.

  Recruiting Phase 2 Washington University School of Medicine · St Louis, Missouri · NCT07673380

• Targeting alcohol-opioid co-use among young adults with a new mobile health tool

  A mobile health app is being tested to help young adults reduce drinking and opioid use when they occur together.

  Recruiting Brown University · Providence, Rhode Island · NCT07663448

• Dexa vs Dexmedetomidine with Bupivacaine in TAP Block for Laparotomy Analgesia

  This study tests whether adding dexamethasone or dexmedetomidine to bupivacaine in a TAP block improves postoperative pain control after laparotomy.

  Recruiting Phase 2/3 Sahiwal medical college sahiwal · Sahiwal, Punjab Province · NCT07590752

• Stress response with desflurane versus opioid-free TIVA during weight-loss surgery

  This study will test whether adding the inhaled anesthetic desflurane to opioid-free anesthesia changes the body's perioperative stress response in people having bariatric (weight-loss) surgery.

  Recruiting G.Gennimatas General Hospital · Athens · NCT07568938

• Erector Spinae Block vs Paravertebral Block for Chronic Pain After Mastectomy

  This trial tests whether an erector spinae block can better prevent chronic pain after mastectomy than a paravertebral block in adults 18–80.

  Recruiting American University of Beirut Medical Center · Beirut · NCT07561411

• Serratus block vs ESP block for pain after unilateral breast surgery

  This trial tests whether the serratus posterior superior intercostal plane block (SPSIPB) provides similar or better pain relief than the erector spinae plane block (ESPB) after unilateral breast surgery in adult women.

  Recruiting Kocaeli City Hospital · İzmit, Kocaeli · NCT07541040

• Mindfulness for fracture recovery and reduced opioid use before and after surgery

  This trial tests whether a brief, guided mindfulness exercise before and after fracture surgery can reduce anxiety and pain and help cut opioid use for adults with fractures.

  Recruiting McMaster University · Hamilton, Ontario · NCT07486505

• Brief alcohol-focused program tailored for people taking buprenorphine

  This project will try a short, opioid-informed alcohol counseling program for adults on prescribed buprenorphine who drink alcohol to see if it reduces drinking and helps them stay in treatment.

  Recruiting University of Notre Dame · Notre Dame, Indiana · NCT07342504

• Lidocaine with or without steroid infusion into the middle meningeal artery for headaches after aneurysmal subarachnoid hemorrhage

  This study will try an infusion of lidocaine, with or without a steroid, into the middle meningeal artery to see if it reduces severe headaches and opioid use in adults recovering from aneurysmal subarachnoid hemorrhage.

  Recruiting Phase 2 The University of Texas Medical Branch, Galveston · Galveston, Texas · NCT07294118

• Kratom and other substances safety in people with past opioid use

  This study tests kratom at different doses against a placebo and oxycodone to see how people with a history of opioid use tolerate and respond to them.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT07218549

• Autonomic Nerve Blockade to Reduce Pain and Nausea After Bariatric Surgery

  This study tests whether an autonomic nerve block given during bariatric surgery can lessen pain and nausea and decrease the need for anti-nausea and pain medicines in the first 72 hours after sleeve gastrectomy or gastric bypass.

  Recruiting Endeavor Health · Evanston, Illinois · NCT07104825

• Pharmacist-led opioid stewardship for adults with chronic non-cancer pain

  This program will test whether a pharmacist-led opioid stewardship program helps adults with chronic non-cancer pain reduce high-risk opioid prescriptions and improve their knowledge and attitudes about opioid use.

  Recruiting Korea University Guro Hospital · Seoul, Seoul · NCT07102446

• MGRNOX-guided general anesthesia to reduce opioid use during laparoscopic gallbladder surgery

  This trial will see if using the EEG-based MGRNOX index to guide anesthesia can reduce opioid use during laparoscopic cholecystectomy in adults.

  Recruiting Peking University Shenzhen Hospital · Shenzhen, Guangdong · NCT07004686

• Lemborexant for insomnia in adults with opioid use disorder on buprenorphine

  This trial will see if taking lemborexant each night for 8 weeks improves sleep, mood, and impulsive behavior in adults with moderate opioid use disorder who are stable on buprenorphine.

  Recruiting Phase 2 Virginia Commonwealth University · Richmond, Virginia · NCT06981195

• Improving opioid treatment and HIV prevention in prisons

  This study is trying to find out what makes it hard to provide opioid treatment in prisons in Tajikistan, Kyrgyzstan, Moldova, and Georgia, so that they can improve care for people with addiction and help prevent HIV.

  Recruiting at 4 sites Yale University · New Haven, Connecticut and 4 other locations · NCT06962033

• Comparing pain relief methods after knee surgery

  This study is testing which pain relief method, Adductor Canal Block or Genicular Nerve Block, works better for people aged 18-72 after knee surgery.

  Recruiting Başakşehir Çam & Sakura City Hospital · Istanbul · NCT06909851

• Using the Nociception Level Index to guide opioid dosing during combined regional and general anesthesia

  This trial tests whether using a Nociception Level Index (NOL) monitor to guide opioid dosing during combined general and regional anesthesia can reduce opioid use and side effects for adults having elective trauma or orthopedic surgery.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg · NCT06905340

• Ketamine during orthopedic trauma surgery to reduce pain, opioid use, and improve mood

  This study will try a single dose of ketamine during surgery to see if it lowers pain and opioid needs and improves depression and PTSD symptoms in adults having major orthopedic trauma surgery.

  Recruiting at 2 sites Phase 4 Texas Tech University Health Sciences Center · Lubbock, Texas and 1 other locations · NCT06903819

• Comparing ketamine delivery methods for postoperative pain management in orthopedic surgery

  This study is testing whether giving ketamine through an IV or a patient-controlled pump works better for managing pain after major orthopedic surgery in adults.

  Recruiting Phase 4 Universidad de Antioquia · Medellín, Antioquia · NCT06774274

• Support for people recovering from opioid overdoses in Seattle

  This study tests a new support center for people recovering from opioid overdoses in Seattle to see if it helps them get better care and stay safe compared to those who don’t use the center.

  Recruiting University of Washington · Seattle, Washington · NCT06768814

• Blocking nerves during gallbladder surgery to reduce pain and nausea

  This study is testing if using a combination of a long-lasting pain medicine and a steroid during gallbladder surgery can help reduce pain and nausea for patients after the operation.

  Recruiting at 2 sites Phase 4 Universidad Simón Bolívar · Barranquilla, Atlantivo and 1 other locations · NCT06753500

• Examining brain activity patterns related to opioid relapse during treatment

  This study is testing how brain activity patterns might predict the risk of relapse to opioid use in people who have just started treatment with methadone or buprenorphine.

  Recruiting at 2 sites Yale University · Hartford, Connecticut and 1 other locations · NCT06651333

• Comparing pain relief methods after lumbar fusion surgery

  This study tests whether a new way of giving local anesthesia during lumbar fusion surgery can help patients feel less pain and use fewer opioids compared to the traditional method.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT06528288

• Comparing two pain management techniques for thoracotomy surgery

  This study is testing two different pain management techniques for patients having thoracotomy surgery to see which one helps reduce the need for opioids.

  Recruiting Kocaeli University · Kocaeli · NCT06507293

• Understanding how psychological factors affect pain management in surgery

  This study looks at how feelings and worries about pain affect how well regional anesthesia works for people having surgery.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06466941

• Evaluating pain management after laparoscopic tubal sterilization

  This study is testing whether a combination of non-opioid pain medications can manage pain just as well as opioids after a laparoscopic tubal sterilization procedure.

  Recruiting Phase 4 Johns Hopkins University · Baltimore, Maryland · NCT06434233

• Comparing two pain management techniques for children undergoing palate surgery

  This study is testing two different pain management techniques for kids aged 6-18 who are having palate surgery to see which one helps them feel less pain after the operation.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06420336

• Smart opioid dispenser and app for patients having a one-level lumbar discectomy or laminectomy

  This test tries a locked opioid-dispensing device plus a smartphone app to help adults having a one-level lumbar discectomy or laminectomy who are opioid-naive or occasional users take oxycodone more safely after discharge.

  Recruiting Hospital for Special Surgery, New York · New York, New York · NCT06358040

• Improving sleep and reducing opioid use in people with chronic pain

  This study is testing if a sleep therapy can help people with chronic pain sleep better and use fewer opioids.

  Recruiting University of South Florida · Tampa, Florida · NCT06345872

• Optimal timing for TAP blocks in bariatric surgery

  This study is testing whether giving a pain relief shot earlier during bariatric surgery helps obese patients recover faster and use less pain medication.

  Recruiting Phase 2 McMaster University · Hamilton, Ontario · NCT06270147

• Nonopioid pain management after surgery for traumatic fractures

  This study tests whether a nonopioid pain management plan can help adults recovering from surgery for traumatic fractures feel better and have fewer side effects than using opioids.

  Recruiting Phase 4 Henry Ford Health System · Detroit, Michigan · NCT06113211

• Syringe-service telemedicine plus social-network HIV prevention program

  This program will test whether training people who inject drugs to recruit and educate their peers through syringe service telemedicine and social networks increases HIV testing and use of prevention and treatment services in Maryland.

  Recruiting Johns Hopkins University · Baltimore, Maryland and 1 other locations · NCT06103370

• Non-invasive pain management after lumbar fusion surgery

  This study is testing if a new non-opioid pain relief method called transcutaneous auricular neurostimulation can help people feel less pain after lumbar fusion surgery.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06100172

• Translating and validating a questionnaire for opioid misuse in Swedish pain patients

  This study is testing a new Swedish questionnaire to see if it can help identify opioid misuse among pain patients who are using opioids for treatment.

  Recruiting Uppsala University · Uppsala, Uppland · NCT06084520

• Using motivational interviewing and mindfulness to help reduce substance use

  This study is testing whether combining motivational interviewing and mindfulness techniques can help people who struggle with using multiple substances, like opioids and tobacco, to reduce their use.

  Recruiting at 2 sites Phase 3 Rutgers, The State University of New Jersey · New Brunswick, New Jersey and 1 other locations · NCT06033599

• Mindfulness training for patients on methadone treatment

  This study is testing if adding mindfulness training to methadone treatment can help people with opioid use disorder manage their pain and reduce their opioid use.

  Recruiting at 2 sites Phase 3 Rutgers, The State University of New Jersey · New Brunswick, New Jersey and 1 other locations · NCT06032559

• Examining the link between sex hormones, pain after surgery, and opioid use

  This study is trying to see if levels of sex hormones like testosterone affect pain and opioid use in young girls aged 11-16 after they have orthopedic surgery.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT06023225

• Preoperative Maxigesic to reduce remifentanil needs during surgery

  We'll see if giving Maxigesic (intravenous ibuprofen plus acetaminophen) before general anesthesia reduces how much remifentanil adults aged 19–60 need during surgery.

  Recruiting Ajou University School of Medicine · Suwon, Gyeonggi-do · NCT06015711

• Using pregabalin and lofexidine to help treat opioid withdrawal in outpatients

  This study is testing if a combination of two medications, pregabalin and lofexidine, can help adults with opioid use disorder feel better during withdrawal and make it easier for them to start a new treatment.

  Recruiting Phase 2 University of Pennsylvania · Baltimore, Maryland and 1 other locations · NCT05995535

• Comparing brain activity in women with chronic pain and opioid use to healthy women

  This study looks at how brain activity differs between women with chronic pain and opioid use and healthy women to help find better treatments for pain.

  Recruiting Duke University · Durham, North Carolina · NCT05905419

• Documenting opioid use and pain management after surgery

  This study looks at how opioids are used for pain management after surgery in adults to see how it affects their recovery and quality of life over time.

  Recruiting University of Aberdeen · Zagreb, Vinogradska 29 and 3 other locations · NCT05877157

• Non-invasive treatment for opioid withdrawal using vagal nerve stimulation

  This study is testing whether a non-invasive treatment using Vagal Nerve Stimulation can help people with opioid use disorders feel better during withdrawal and reduce cravings.

  Recruiting at 5 sites Phase 3 Emory University · Atlanta, Georgia and 5 other locations · NCT05834478

• Exploring how meditation affects pain relief in patients with chronic low back pain on opioids

  This study tests whether mindfulness meditation can help people with chronic low back pain who are taking opioids feel less pain.

  Recruiting University of Utah · La Jolla, California and 1 other locations · NCT05607381

• Investigating treatments for sleep apnea in veterans using opioids

  This study is testing whether certain treatments can help veterans with sleep apnea who use opioids breathe better and improve their quality of life.

  Recruiting Phase 1/2 VA Office of Research and Development · Detroit, Michigan · NCT05589753

• Device for dispensing opioids after cancer surgery

  This study tests a new device that gives cancer patients their pain medication after surgery to see if it's easier and safer to use than regular pill bottles.

  Recruiting Columbia University · New York, New York · NCT05585788

• Personalized pain management for cesarean sections

  This study is testing a new way to manage pain for breastfeeding mothers after cesarean sections to see if it can reduce side effects from opioids and improve recovery for both moms and their babies.

  Recruiting at 3 sites University of Pittsburgh · Indianapolis, Indiana and 3 other locations · NCT05380531

• ESP nerve block versus wound infiltration for pain after laminectomy

  This trial will try whether an erector spinae plane (ESP) block or wound infiltration gives better pain relief and reduces opioid use for adults having a one- or two-level laminectomy.

  Recruiting University of Padova · Padova, Veneto · NCT05271331

• Using steroids during lumbar surgery to reduce pain and opioid use

  This study tests if using steroids during back surgery can help reduce pain and the need for opioids in patients recovering from the procedure.

  Recruiting Phase 3 Hospital for Special Surgery, New York · New York, New York · NCT05058287

• Using virtual reality and scents to reduce pain and anxiety after heart surgery

  This study is testing whether using virtual reality and scents can help reduce pain and anxiety for people recovering from heart surgery.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT04912531

• Opioid-free anesthesia for abdominal aortic aneurysm repair

  This study is testing a new way to manage pain during and after surgery for abdominal aortic aneurysm repair without using opioids, to see if it helps patients recover better.

  Recruiting Phase 4 University of Crete · Heraklion, Crete · NCT04894864

• Community-based program for youth with opioid use disorder

  This study is testing a community program that helps young people with opioid use disorder get better treatment and support to see if it keeps them engaged in recovery and reduces overdoses.

  Recruiting Phase 4 The University of Texas Health Science Center, Houston · Houston, Texas · NCT04811014

• Testosterone treatment for pain relief in men with opioid-induced low testosterone

  This study is testing if testosterone treatment can help men with chronic spinal pain and low testosterone from using opioids feel better and improve their quality of life.

  Recruiting Phase 2 Brigham and Women's Hospital · Boston, Massachusetts · NCT04798469

• Mindfulness practice for patients with endometrial and cervical cancer

  This study is testing whether using a mindfulness app can help women with endometrial or cervical cancer feel less stressed and anxious before their surgery or treatment.

  Recruiting St. Louis University · St Louis, Missouri · NCT04512144

• Investigating opioid prescriptions after hip arthroscopy

  This study is testing if giving fewer pain pills after hip surgery can still help patients manage their pain while using less medication.

  Recruiting Rush University Medical Center · Chicago, Illinois · NCT04094701

• Standardized opioid prescriptions after hand and forearm surgery

  This study tests if a set prescription for pain medication after hand and forearm surgery can help patients use fewer unused opioid pills while still managing their pain effectively.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT04044820

• Comparing opioids and non-opioids for pain management after knee surgery

  This study is testing whether non-opioid pain medications can work as well as opioids for people recovering from knee surgery.

  Recruiting Phase 4 Sanford Health · Fargo, North Dakota · NCT03858231

• Using Toradol for Pain Control After Prophylactic Femoral Nailing

  This study is testing whether adding Toradol to opioid pain relief can help patients recovering from surgery on their femur feel better while using fewer narcotics.

  Recruiting Phase 3 St. Louis University · St Louis, Missouri · NCT03823534

• Program to reduce opioid use in chronic pain patients after surgery

  This study is testing a new program to help chronic pain patients use less opioids after surgery by providing pain education and support tools.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT03675386

NIH-funded research (newest 40 of 534)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Systems analysis to improve opioid use disorder care after jail release (SAIA-MOUD)

  A program to help people with opioid use disorder get better, faster, and safer care after they leave jail.

  NIH research University of Washington · Seattle, United States · NIH-11599161

• Precise epigenetic drugs for opioid addiction

  A tiny, targeted drug approach is being developed to help people with opioid use disorder by rewriting the epigenetic signals in the brain to reduce cravings and relapse risk.

  NIH research Boston Interactome, INC. · Boston, United States · NIH-11578588

• Increasing Access to Medications for Opioid Use Disorder for Unhoused Montanans

  This project helps unhoused people in Montana get life-saving medicines for opioid use disorder through clinics connected to syringe service programs, a nurse-led MOUD model, and peer support.

  NIH research Open Aid Alliance · Missoula, United States · NIH-11578581

• Optimizing long-acting PrEP and opioid treatment for people in jails and prisons

  This project tests a real-world approach to using long-acting PrEP and buprenorphine for HIV prevention and opioid treatment among incarcerated individuals and after release.

  NIH research Duke University · Durham, United States · NIH-11565766

• Scaling up medications for opioid use disorder in residential treatment programs

  This grant studies how to help residential treatment programs provide medications for opioid use disorder to reduce overdoses after discharge, focusing on real-world settings and policies.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11535207

• Increasing Capacity at a Native Community Clinic to Improve Opioid Care for urban AI/AN

  This grant helps a Native American health clinic build its research capacity to better serve urban American Indian and Alaska Native people dealing with opioid use disorder and related health issues.

  NIH research Native American Community Clinic · Minneapolis, United States · NIH-11533803

• Multimodal fetal and placental imaging to predict outcomes in infants exposed to opioids

  This project uses brain and placenta imaging plus biomarkers to understand how prenatal opioid exposure affects babies and how to predict and improve outcomes for infants born to mothers with opioid use disorder.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11518816

• Safer ibogaine-based medicine for opioid use disorder

  A new synthetic iboga alkaloid candidate, GM-3009, is being developed to treat opioid use disorder with fewer safety risks and better effectiveness.

  NIH research Gilgamesh Pharma INC · New York, United States · NIH-11513538

• Improving care for opioid use disorder in the ICU

  This project helps hospital staff in intensive care units provide better care for patients with opioid use disorder.

  NIH research Mainehealth · Portland, United States · NIH-11477142

• Pain sensitivity, alcohol analgesia, and heavy drinking in people with opioid use disorder

  A short, patient-friendly look at how pain sensitivity and alcohol’s pain-relieving effects might influence heavy drinking in people with opioid use disorder.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11461099

• Health impacts of housing programs for people who are homeless and use opioids

  This project follows people who are homeless and use opioids to see how different housing and treatment policies affect overdose and health outcomes.

  NIH research Boston Medical Center · Boston, United States · NIH-11459532

• Opioid Use Disorder County Prevalence Using Recapture Estimates (OUD CAPTURE)

  Aimed at estimating how common opioid use disorder is across counties using advanced statistical methods to help target treatment and resources.

  NIH research University of Kentucky · Lexington, United States · NIH-11457463

• Effects of prescription opioid use during pregnancy on a mother's brain after birth

  This project looks at how taking prescription opioids during pregnancy changes a mother's brain and behavior after her baby is born.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11457183

• How a thalamus-to-reward-center brain circuit may drive opioid craving and relapse

  This project looks at how specific brain connections between the thalamus and the brain's reward center may drive cravings and relapse during opioid withdrawal for people recovering from opioid use.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11454843

• Tailored opioid tapering and pain support after spine surgery for patients using opioids long-term

  A Stanford-backed plan helps people who already take opioids before spine surgery to taper safely after surgery and get non-opioid pain relief.

  NIH research Stanford University · Stanford, United States · NIH-11454729

• Team-based care for pregnant women with opioid use disorder in rural clinics

  A team-based care model is being adapted for rural obstetric settings to help pregnant women with opioid use disorder start and continue medications and improve health outcomes for them and their babies.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11454658

• Digital toolkit to improve IPV screening and care in opioid use disorder

  A digital toolkit helps clinics screen for intimate partner violence and connect people with IPV-related care for those being treated for opioid use disorder.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11454644

• Mobile health support for people with opioid use disorder and PTSD after residential treatment

  A mobile health tool will help adults with opioid use disorder and PTSD stay connected to support after they leave residential treatment.

  NIH research University of Rhode Island · Kingston, United States · NIH-11454643

• Postsurgical pain and opioid use in older adults with mild cognitive impairment

  This grant studies how mild cognitive impairment in older adults affects pain after surgery and how opioids are used, with the goal of improving safer, better pain management.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11449194

• Understanding withdrawal circuits in opioid use disorder and how to interrupt relapse

  Researchers are studying specific brain circuits related to withdrawal in opioid use disorder to identify targets that could help prevent relapse.

  NIH research Washington State University · Pullman, United States · NIH-11447945

• Medications for opioid use disorder in older adults with multiple health issues

  This project looks at how older adults living with opioid use disorder and multiple chronic conditions respond to medications for opioid use disorder.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11447399

• Let-7 MicroRNA Link Between Adolescent Opioid Exposure and Future Opioid Use in Rats and Humans

  This grant studies how opioid use during adolescence in males might change sperm and affect kids or future generations, using both rat models and human data.

  NIH research Tufts University Boston · Boston, United States · NIH-11428132

• Oral health effects of buprenorphine and methadone in people with opioid use disorder

  This project will explore how common MOUD medicines like buprenorphine (including dissolvable forms) and methadone may affect oral health in people with opioid use disorder.

  NIH research Chestnut Health Systems, INC. · Bloomington, United States · NIH-11427115

• Psilocybin and opioid use disorder: a crossover trial to understand how psilocybin might help reduce relapse risk

  A Johns Hopkins-led study will test whether a single high dose of psilocybin can change withdrawal and craving in adults with opioid use disorder, using a careful crossover design to compare two doses.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11425436

• Antibody treatment that soaks up fentanyl to prevent overdoses

  A new antibody medicine that soaks up fentanyl and similar opioids is being developed to protect people at high risk of overdose.

  NIH research Mclean Hospital · Belmont, United States · NIH-11422441

• How Medicaid expansion could help recently released people get medications for opioid use disorder and mental health care

  This grant studies how extending Medicaid after release from jail or prison could help people with opioid use disorder and mental health needs stay on treatment and avoid overdose.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11422049

• High-Dose Medications for Opioid Use Disorder and Retention in Care

  This project tests whether adjusted, higher-dose MOUD regimens can help people stay in treatment and reduce overdose risks during the fentanyl crisis.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11422040

• RNA location and local protein-making in brain circuits tied to opioid use disorder

  A study exploring how RNA localization and local protein production in brain cells contribute to lasting brain changes and relapse risk in people with opioid use disorder.

  NIH research Trustees of Indiana University · Bloomington, United States · NIH-11420281

• Bright light therapy to improve sleep and recovery in opioid use disorder

  This project tests whether morning bright light therapy can improve sleep, circadian rhythms, brain signaling, and treatment outcomes for people with opioid use disorder.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11417330

• SHE-OUD: a quick, private screen-and-help program for women in opioid treatment

  A brief, computer-based screening and intervention is tested to help women with opioid use disorder who have experienced sexual violence and PTSD, aiming to improve their treatment outcomes.

  NIH research Rhode Island Hospital · Providence, United States · NIH-11415934

• Using new linked databases to cut postoperative opioid use after inpatient surgery

  A study using linked patient data from hospital records to understand and reduce long-term opioid use after surgery, especially in older adults.

  NIH research Stanford University · Stanford, United States · NIH-11415076

• Improving Access to Medications for Opioid Use Disorder in Medicare Beneficiaries

  This project aims to make FDA-approved medications for opioid use disorder more accessible to people covered by Medicare.

  NIH research Rand Corporation · Santa Monica, United States · NIH-11413739

• Improving back-pain care in rural areas with tele-physical therapy

  This project tests a tele-rehabilitation program to help adults with chronic low back pain in rural communities access physical therapy and reduce opioid use.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11412950

• Housing and opioid treatment strategies to improve health for people experiencing homelessness and opioid use disorder

  A Stanford-led project will model how housing and opioid treatment interventions could reduce HIV, HCV, and related diseases among people who are unhoused and struggle with opioid use disorder.

  NIH research Stanford University · Stanford, United States · NIH-11411062

• Cannabinoid CB2 receptor activators for opioid use disorder

  A new treatment approach uses a CB2 receptor activator to reduce cravings and drug reward in people with opioid use disorder.

  NIH research Longieva Therapeutics · Menlo Park, United States · NIH-11410429

• Medicaid coverage of reentry health supports for opioid use disorder after prison release

  A mentored research grant explores how Medicaid-backed post-incarceration health navigation and social-linkage services affect care and outcomes for people with opioid use disorder after they leave prison.

  NIH research Baystate Medical Center, INC. · Springfield, United States · NIH-11408810

• Transforming how we measure opioid use disorder and expand life-saving care

  This project will combine health data from several countries to better estimate how many people have opioid use disorder and how well treatment and prevention efforts are working.

  NIH research University of New South Wales · Sydney, Australia · NIH-11408702

• HEALing Measurement Center: Improving opioid use disorder care with better measurement in Pennsylvania

  A Pennsylvania effort to improve opioid use disorder treatment by using measurement-based care to keep people in recovery and reduce overdose deaths.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11408540

• Optimizing opioid treatment for people leaving prison

  This project tests simple screening and a small diagnostic checklist to help identify opioid use disorder in prisoners and link them to medication for opioid use disorder (MOUD) when they’re released.

  NIH research University of Washington · Seattle, United States · NIH-11406216

• Sleep problems and opioid use after adolescent surgery

  This project looks at how sleep problems after surgery may influence whether teens start using prescribed opioids in risky ways.

  NIH research Stanford University · Stanford, United States · NIH-11406197

Related topics

Quick answers

How many Opioid Use clinical trials are recruiting right now?

59, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in United States (38 trials), Canada (4 trials), Turkey (Türkiye) (4 trials), Colombia (2 trials), South Korea (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 8, Phase 2: 6, Phase 3: 5, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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