Bundled telehealth, peer support, and buprenorphine after ED discharge to prevent opioid overdoses

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized or controlled study examines whether a bundled intervention delivered after emergency department discharge—comprising telemedicine, peer support, buprenorphine treatment, and facilitated linkage to ongoing care—can increase treatment uptake and reduce repeat overdoses among adults with opioid use disorder. The intervention targets patients discharged from the UAB hospital who have ongoing needs after an overdose and are willing to continue buprenorphine. The study compares the bundled approach to standard or alternate care, with outcomes focused on treatment engagement, repeat overdoses, and overdose-related mortality. The HEAL Initiative supports the project, and the trial emphasizes practical implementation in the ED/post-discharge setting. Eligibility includes age, language, diagnosis, and geographic criteria, with specific exclusions to ensure safety and feasibility.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. discharged from the ED and inpatient settings at the UAB hospital
2. 19 years or older (the age of majority in Alabama);
3. diagnosis of OUD and experiencing opioid overdose in the last 12 months;
4. prescribed buprenorphine in the ED and willing to continue buprenorphine post-ED discharge;
5. English speaking;
6. not actively psychotic and suicidal, or cognitively impaired.
7. Patients who are admitted to the hospital from the ED will be eligible for enrollment.

Exclusion Criteria:

1. living in a restricted environment (e.g., prison or jail facility, etc.);
2. currently enrolled in other clinical studies;
3. anticipated to take other prescribed opioids except buprenorphine for a medical condition longer than three months;
4. known allergic reaction to buprenorphine;
5. critically ill or injured;
6. females with pregnancy (they are anticipated to request a higher level of care).
7. living outside of Alabama

Where it's running

• UAB
  Birmingham, Alabama, United States Recruiting

Study contacts

• Principal investigator: Li Li, MD;PhD — University of Alabama at Birmingham
• Study coordinator: Li Li, MD;PhD
• Email: liyli@uabmc.edu
• Phone: 2059346269

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• emPath platform pilot to link and keep adults with opioid use disorder in care in Durham

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• STORC: Training a support person plus patient navigation after birth

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.