Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Methadone Patient Access to Collaborative Treatment

Official title: Methadone Patient Access to Collaborative Treatment (MPACT)

Run by University of Arizona · NCT06556602 · Data updated 2026-11-12

This trial tests a program called MPACT to see if it helps people stay in methadone treatment and reduces overdoses, while also examining how staff and patient stress affect implementation.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment1080 (estimated)
SponsorUniversity of Arizona
Academic / other
Locations1 site (Tucson, Arizona)
StatusRecruiting
StartedFebruary 5, 2026
Main results expectedApril 30, 2029
Study endsJune 30, 2029
Registry record updatedJuly 16, 2026
Trial IDNCT06556602 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal participants are staff members providing methadone treatment at enrolled opioid treatment programs.

Probably not a fit

Patients receiving methadone at the enrolled programs may not directly benefit from the trial outcomes; participation is limited to staff for the stated inclusion criteria.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

MPACT is a 15-month, cluster-randomized study conducted in 30 clinics, enrolling 600 patients and 480 staff. The trial refines the MPACT materials and training, then measures effects on methadone treatment practices, program culture, retention, and in-treatment overdoses. It also investigates how staff and patient trauma symptoms relate to both outcomes and how the intervention is put into practice. The study uses a Hybrid Type 1 design to balance effectiveness evaluation with implementation insights across treatment programs. Lead sponsorship is from the University of Arizona, with the study taking place at the University of Arizona College of Nursing in Tucson.

Why it matters

Potential benefit: If successful, MPACT could improve retention in methadone programs and reduce overdose risk for patients while providing insight into how trauma affects treatment implementation.

How similar studies have gone: Prior research in similar implementation approaches has shown potential benefits, but this trial explores a novel focus on staff and patient trauma as factors influencing success.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Staff providing methadone treatment services at the enrolled opioid treatment programs

Exclusion Criteria:

* Patients receiving methadone treatment at the enrolled opioid treatment programs

Where it's running

  • University of Arizona College of Nursing
    Tucson, Arizona, United States
    Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.