Clinical trial Recruiting at 1 site Phase 1 Interventional Ages 18 to 55

Effects of cannabis on opioid withdrawal in individuals with opioid use disorder

Official title: Cannabis Modulation of Outcomes Related to Opioid Use Disorder: Opioid Withdrawal, Abuse Potential and Safety

Run by University of Kentucky · NCT05729932 · Data updated 2026-11-12

This study is testing whether inhaled cannabis can help people with opioid use disorder feel better during withdrawal.

More Opioid Use Disorder trials

Quick facts

PhasePhase 1
Study typeInterventional
Ages18 Years to 55 Years
SexAll
Enrollment15 (estimated)
SponsorUniversity of Kentucky
Academic / other
Locations1 site (Lexington, Kentucky)
StatusRecruiting
StartedSeptember 10, 2024
Main results expectedJune 30, 2027
Study endsJune 30, 2027
Registry record updatedJune 18, 2026
Trial IDNCT05729932 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are individuals with a current diagnosis of opioid use disorder who are not actively seeking treatment.

Probably not a fit

Patients with current medical conditions that require medical management may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to enroll participants diagnosed with opioid use disorder who are not currently seeking treatment. It will assess the effects of inhaled vaporized cannabis on opioid withdrawal symptoms and related outcomes. The study will utilize a Phase 1 interventional approach to evaluate the safety and efficacy of cannabis in this population. Participants will receive both cannabis and intranasal opioids as part of the intervention.

Why it matters

Potential benefit: If successful, this study could provide a novel treatment option for managing opioid withdrawal symptoms.

How similar studies have gone: While there is ongoing research into cannabis for various conditions, this specific approach to treating opioid use disorder is relatively novel and has not been extensively tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Current opioid use disorder

Exclusion Criteria:

* Current medical conditions that require medical management

Where it's running

  • Center on Drug and Alcohol Research
    Lexington, Kentucky, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.