Effects of cannabis on opioid withdrawal in individuals with opioid use disorder
Official title: Cannabis Modulation of Outcomes Related to Opioid Use Disorder: Opioid Withdrawal, Abuse Potential and Safety
Run by University of Kentucky · NCT05729932 · Data updated 2026-11-12
This study is testing whether inhaled cannabis can help people with opioid use disorder feel better during withdrawal.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 55 Years |
| Sex | All |
| Enrollment | 15 (estimated) |
| Sponsor | University of Kentucky Academic / other |
| Locations | 1 site (Lexington, Kentucky) |
| Status | Recruiting |
| Started | September 10, 2024 |
| Main results expected | June 30, 2027 |
| Study ends | June 30, 2027 |
| Registry record updated | June 18, 2026 |
| Trial ID | NCT05729932 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals with a current diagnosis of opioid use disorder who are not actively seeking treatment.
✕Probably not a fit
Patients with current medical conditions that require medical management may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to enroll participants diagnosed with opioid use disorder who are not currently seeking treatment. It will assess the effects of inhaled vaporized cannabis on opioid withdrawal symptoms and related outcomes. The study will utilize a Phase 1 interventional approach to evaluate the safety and efficacy of cannabis in this population. Participants will receive both cannabis and intranasal opioids as part of the intervention.
Why it matters
Potential benefit: If successful, this study could provide a novel treatment option for managing opioid withdrawal symptoms.
How similar studies have gone: While there is ongoing research into cannabis for various conditions, this specific approach to treating opioid use disorder is relatively novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Current opioid use disorder Exclusion Criteria: * Current medical conditions that require medical management
Where it's running
-
Center on Drug and Alcohol Research
Lexington, Kentucky, United States Recruiting
Study contacts
- Principal investigator: Shanna Babalonis, PhD — University of Kentucky
- Study coordinator: Paul Nuzzo, MA
- Email: pnuzz2@email.uky.edu
- Phone: 859-323-0002
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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CBD for Opioid Dependence and Pain on Buprenorphine
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-
Cebranopadol for opioid withdrawal in adults with chronic pain
This study tests whether cebranopadol can reduce withdrawal symptoms in adults with chronic pain who are physically dependent on prescribed opioids, compared with placebo.
-
emPath platform pilot to link and keep adults with opioid use disorder in care in Durham
This pilot tests a mobile app and telemedicine approach to help adults with opioid use disorder start and stay in MOUD through community outreach in Durham, NC.
-
CB1 Receptors in Opioid Use Disorder Measured with a PET Radioligand
This study tests CB1 receptor availability in people with opioid use disorder starting opioid agonist therapy and compares them with healthy adults.
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STORC: Training a support person plus patient navigation after birth
We’re testing whether training a designated support person and using patient navigation after delivery helps people with opioid use disorder build recovery resources and stay in treatment.
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Personalized Addiction Treatment Enhancement for Opioid Use Disorder
A digital platform run by peer recovery supporters will be tested to help adults with opioid use disorder who are on buprenorphine or methadone stay in treatment and improve outcomes.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.