Predicting psychosis risk in teens using multiple biomarkers and data
Official title: Trajectories and Predictors in the Clinical High Risk for Psychosis Population: Prediction Scientific Global Consortium (PRESCIENT)
Funded at University of Melbourne · NIH-11528613 · Data updated 2026-11-12
This project looks at teens at high risk for psychosis and uses multiple health data pieces to predict who might develop serious symptoms.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Melbourne NIH-funded |
| Lab location | 1 site (Melbourne, Australia) |
| Project start | September 8, 2020 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $91,174 |
| NIH project number | 3U01MH124631-06S7 |
| Project ID | NIH-11528613 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adolescents aged 12-20 identified as Clinical High Risk for psychosis and willing to participate in long-term follow-up.
✕Less likely to help
Some participants may not experience changes in their risk status or outcomes during the study.
What this research studies
Teenagers at high risk for psychosis are being followed over time with regular biomarker tests and clinical check-ins to build better prediction models. The goal is to combine biological markers and clinical information to forecast outcomes like conversion to psychosis, symptom changes, and functional recovery. The study runs as part of a large international effort and has already recruited many participants to understand how early signals relate to later health.
Why it matters
Potential benefit: If successful, this work could improve early identification and personalized care for youth at risk, potentially guiding timely interventions.
How similar studies have gone: Previous large-scale efforts have shown that combining biomarkers with clinical data can improve prediction of psychosis risk, though precise models continue to be refined.
Where this research is happening
-
University of Melbourne
Melbourne, Australia Active
Researchers
- Principal investigator: Nelson, Christopher Barnaby — University of Melbourne
- Study coordinator: Nelson, Christopher Barnaby
Related research
Other NIH-funded projects on the same topics.
-
Psychosis in diverse settings across the world
This project studies how psychotic disorders show up and respond to treatment in adults with diverse backgrounds, including populations in Africa, the Caribbean, and other Global South settings.
-
Psychosis in Diverse Settings: Understanding Symptoms and Treatment Across Global South
A human-facing study will look at how psychotic disorders present and respond to treatment in adults from Africa, the Caribbean, and other Global South settings, using genetic and clinical data.
-
A new online brain-scan-style tool to spot early psychosis risk
A new online-based set of tasks and a computer model aims to identify people at high risk for developing psychosis earlier and more accurately.
-
Genetic clues for early-onset psychosis in Latino youth
This project looks at the genes of young people with early-onset psychosis and compares them with similar youths without psychosis to find genetic factors that contribute to the illness.
-
Biomarkers to tailor rehab for Veterans with schizophrenia
A clinician-scientist is developing a brain-based biomarker to guide personalized rehabilitation for Veterans with schizophrenia.
-
Computational analysis of facial expression in early psychosis
Aims to develop computer-based measures of facial expression in people at risk for or with schizophrenia to help track symptoms and guide future trials.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.