PREDICT: Data-driven tools to understand and coordinate early psychosis risk in youth
Official title: Psychosis Risk Evaluation, Data Integration and Computational Technologies (PREDICT): Data Processing, Analysis, and Coordination Center
Funded at Brigham and Women's Hospital · NIH-11519474 · Data updated 2026-11-12
Aciient-style data platform and analysis center will combine big datasets and AI methods to improve how we predict and study early signs of psychosis in children and adolescents.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 9, 2020 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $5,221,430 |
| NIH project number | 4U24MH124629-06 |
| Project ID | NIH-11519474 on NIH RePORTER |
Who could benefit from this research
✓Could help
Youth aged 0-18 who are at clinical high risk for psychosis or exhibited attenuated psychotic symptoms.
✕Less likely to help
The project focuses on data integration and methods; individual participants may not directly benefit unless their data are used in future trials.
What this research studies
This grant creates a centralized hub that collects, processes, and analyzes data from different studies of young people at clinical high risk for psychosis. It uses advanced algorithms to find meaningful patterns across heterogeneous datasets and to identify new biomarkers and subtypes that could guide future clinical trials. The center emphasizes collaboration, data sharing, and rigorous data management to ensure reliable results that can translate to better early interventions. By focusing on outcomes beyond psychosis, the work aims to address broader functional and mental health needs of youth at risk.
Why it matters
Potential benefit: If successful, it could lead to better prediction, earlier and more personalized interventions, and improved outcomes for youth at risk of psychosis.
How similar studies have gone: Previous CHR research has shown that data integration and advanced analytics can reveal meaningful subtypes and biomarkers, though this approach is still developing.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Shenton, Martha E. — Brigham and Women's Hospital
- Study coordinator: Shenton, Martha E.
Related research
Other NIH-funded projects on the same topics.
-
Psychosis in diverse settings across the world
This project studies how psychotic disorders show up and respond to treatment in adults with diverse backgrounds, including populations in Africa, the Caribbean, and other Global South settings.
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Psychosis in Diverse Settings: Understanding Symptoms and Treatment Across Global South
A human-facing study will look at how psychotic disorders present and respond to treatment in adults from Africa, the Caribbean, and other Global South settings, using genetic and clinical data.
-
A new online brain-scan-style tool to spot early psychosis risk
A new online-based set of tasks and a computer model aims to identify people at high risk for developing psychosis earlier and more accurately.
-
Genetic clues for early-onset psychosis in Latino youth
This project looks at the genes of young people with early-onset psychosis and compares them with similar youths without psychosis to find genetic factors that contribute to the illness.
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Biomarkers to tailor rehab for Veterans with schizophrenia
A clinician-scientist is developing a brain-based biomarker to guide personalized rehabilitation for Veterans with schizophrenia.
-
Computational analysis of facial expression in early psychosis
Aims to develop computer-based measures of facial expression in people at risk for or with schizophrenia to help track symptoms and guide future trials.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.