Network to understand early signs of psychosis
ProNET: Psychosis-Risk Outcomes Network
['FUNDING_U01'] · YALE UNIVERSITY · NIH-11493632
This network follows people at clinical high risk for psychosis and healthy volunteers to look for brain, speech, blood, genetic, and smartphone signals that predict who develops psychotic disorders.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11493632 on ClinicalTrials.gov |
What this research studies
I would join a large international network that follows people at high risk for psychosis and healthy volunteers over 24 months. Participants complete detailed tests including MRI and EEG scans, blood and genetic tests, speech and cognitive measures, clinical interviews, and passive smartphone data across eight visits. Biomarkers are collected at two timepoints to map how brain and behavior change, and symptom trajectories are tracked at multiple timepoints to link markers with outcomes. The project combines these multi-modal measures to find patterns that predict who is most likely to develop psychotic disorders or need specific treatments.
Who could benefit from this research
Good fit: Ideal candidates are young people identified as being at clinical high risk for psychosis (attenuated psychotic symptoms) and healthy volunteers for comparison.
Not a fit: People already in a full psychotic episode, those without any risk signs, or those unable or unwilling to undergo MRI/EEG or provide smartphone data may not directly benefit.
Why it matters
Potential benefit: If successful, this could help detect people at highest risk earlier and guide personalized treatments to prevent or reduce psychosis.
How similar studies have performed: Smaller CHR studies have found some promising biomarkers but results have been inconsistent, so this larger, multi-site, multi-modal effort is more comprehensive and partly novel.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WOODS, SCOTT W — YALE UNIVERSITY
- Study coordinator: WOODS, SCOTT W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.