PREMAP: Predictors of Menopause-Related Psychosis
Official title: PREMAP - Predictors and Risk Evaluation for Menopause-Associated Psychosis
Funded at Yale University · NIH-11520455 · Data updated 2026-11-12
A study to understand what factors predict psychosis that can occur during menopause, with a focus on women going through that transition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 18, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $415,071 |
| NIH project number | 3R01MH131768-04S1 |
| Project ID | NIH-11520455 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women in the menopause transition, especially those with or at risk for psychosis, and individuals at clinical high risk for psychosis.
✕Less likely to help
Women not in the menopause transition or without risk factors for psychosis may see limited direct benefit.
What this research studies
This project looks at what might signal the onset of psychosis in women during the menopause transition. It mixes retrospective analysis of past cases with a prospective follow-up of high-risk women over two years, collecting clinical, behavioral, hormonal, and brain-related data. The goal is to identify risk markers that could help clinicians monitor and support patients as they approach menopause. Results from this work could inform better screening, timing of interventions, and personalized care for affected individuals.
Why it matters
Potential benefit: If successful, the research could improve early identification and targeted support for women at risk of menopause-related psychosis.
How similar studies have gone: Previous work has begun to identify risks, with ongoing studies suggesting this is a promising area for improving prediction and care.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Powers, Albert R — Yale University
- Study coordinator: Powers, Albert R
Related research
Other NIH-funded projects on the same topics.
-
Risk factors for psychosis during the menopause transition
This project looks for medical, reproductive, psychiatric, and family-history signs that might predict new psychosis in women going through the menopause transition.
-
Identifying risk factors for psychosis during menopause
This study is looking at how hormonal changes during menopause might lead some women to experience psychosis, and it’s inviting women who have had their first episode of psychosis during this time to share their health histories so we can better understand how to help those who might be at risk.
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Psychosis in diverse settings across the world
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Psychosis in Diverse Settings: Understanding Symptoms and Treatment Across Global South
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A new online brain-scan-style tool to spot early psychosis risk
A new online-based set of tasks and a computer model aims to identify people at high risk for developing psychosis earlier and more accurately.
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Understanding how vaginal tissue changes after menopause affect reproductive health
A research team is studying why the vaginal lining changes after menopause and how this affects health, with potential solutions to improve comfort and reduce infection risk for postmenopausal women.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.