Condition

Depression - Major Depressive Disorder clinical trials and research

As of November 12, 2026, Find a Trial lists 81 Depression - Major Depressive Disorder clinical trials that are recruiting, at sites in 26 countries (most in United States (29), Canada (8), China (7)). 2 were first registered in the last 30 days. By phase: Phase 2 (5), Phase 1/2 (4), Phase 1 (3), Phase 4 (3). The most active sponsors are First Affiliated Hospital of Chongqing Medical University (3), Massachusetts General Hospital (3), Peking University (3). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.

Newest Depression - Major Depressive Disorder clinical trials

StudyPhaseWhereStatusRegistered
Understanding how the orbitofrontal cortex guides approach vs. avoidance in depression — San Francisco, California Recruiting Oct 27, 2026
Health education program to help depression in older adults and caregivers in Ho Chi Minh City — Ho Chi Minh City, Cho Lon Recruiting Oct 16, 2026
Prucalopride for low mood: testing a 5-HT4 receptor activator for cognition and sleep — Oxford, Oxfordshire Recruiting Sep 30, 2026
Pre-visit Companion Brief: a primary care AI-assisted check for depression and anxiety — Brentwood, New York and 1 other locations Recruiting Sep 22, 2026
Medically tailored groceries to help depression in people with food insecurity — Worcester, Massachusetts and 2 other locations Recruiting Aug 21, 2026
Health and Work Ability After Inpatient Treatment for Stress-Related Disorders: Follow-Up of the HARMODI Cohort — Süs and 1 other locations Recruiting Aug 11, 2026
ADAPT: a new parenting program to help depressed parents improve their kids’ behavior — Toronto, Ontario Recruiting Aug 6, 2026
Longitudinal look at how lasting TMS benefits can be predicted for depression — Rennes Recruiting Jul 6, 2026
Biomarker-guided antidepressant choice to see if rTMS or ketamine works best for you Phase 4 New York, New York and 1 other locations Recruiting Jul 2, 2026
High-dose bilateral tDCS for older adults with late-life depression Phase 1/2 Dallas, Texas Recruiting Jun 18, 2026

All recruiting trials (81)

Related topics

AnxietyDepressionDepression, BipolarTreatment Resistant Depression (TRD)BipolarBipolar Disorder (BD)Chronic PainCritical Illness RecoveryDepression Anxiety DisorderDepression ChronicDepression DisorderDepression DisordersDepressive DisorderLate Life Depression (LLD)

Quick answers

How many Depression - Major Depressive Disorder clinical trials are recruiting right now?

81, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 26 countries. The most sites are in United States (29 trials), Canada (8 trials), China (7 trials), Spain (4 trials), United Kingdom (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 1/2: 4, Phase 1: 3, Phase 4: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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Last reviewed 2026-11-12 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.