Condition

Cannabis Use Disorder clinical trials and research

• 30Clinical trials
• 25NIH research projects
• 1New in 30 days
• 7Countries

Newest Cannabis Use Disorder clinical trials

All recruiting trials (30)

• Can tACS modulate motivation and reward signals in cannabis use disorder and depression

  We’re testing whether a gentle brain stimulation method (tACS) can boost motivation and reward responses in adults with cannabis use and/or depression to see if it helps with anhedonia.

  Recruiting Florida State University · Tallahassee, Florida and 1 other locations · NCT07924852

• Sex differences in how cannabis affects people who regularly use it

  This Phase 2 trial tests whether men and women who use cannabis several days a week respond differently to THC versus placebo.

  Recruiting Phase 2 Medical University of South Carolina · Charleston, South Carolina · NCT07815691

• Semaglutide for cannabis use disorder: see if a medicine helps reduce use

  This study tests whether weekly injections of semaglutide can help adults with cannabis use disorder reduce their cannabis use compared with placebo.

  Recruiting Phase 2 Psychiatric Centre Rigshospitalet · Frederiksberg · NCT07523633

• Brain imaging to predict teens' response to cannabis treatment

  This project will test whether teens' brain activity during a learning task can predict how well 14–17-year-olds do in a 10-week virtual reward program to reduce cannabis use.

  Recruiting Indiana University · Indianapolis, Indiana · NCT07340554

• Reducing cannabis use to improve daily functioning.

  This program will try an 8-week combination of motivational interviewing, computerized CBT (CBT4CBT), and small financial rewards to help adults with cannabis use disorder cut back on cannabis.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07218471

• Home-based brain stimulation with guided mindfulness for cannabis use disorder

  This project tests whether daily at-home mild brain stimulation plus guided mindfulness can help adults with cannabis use disorder reduce or stop their cannabis use.

  Recruiting NYU Langone Health · New York, New York · NCT07184983

• 12-week aerobic exercise program for people using cannabis

  This program will try a 12-week indoor cycling regimen to see if regular exercise reduces cannabis dependence and the severity of cannabis use disorder in adults aged 18–40.

  Recruiting The University of Hong Kong · Hong Kong · NCT07091292

• Action-based cognitive remediation for alcohol and cannabis misuse in early psychosis

  This project will test whether action-based cognitive remediation helps young people with early psychosis cut down on alcohol and cannabis use.

  Recruiting at 2 sites Nova Scotia Health Authority · St. John's, Newfoundland and Labrador and 1 other locations · NCT07056894

• Oral saliva testing to detect recent cannabis use in young adults.

  This project will test whether at-home saliva tests can detect recent cannabis use in 18-to-30-year-olds who use cannabis at least once a week.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT06891235

• Treatment for quitting cigarettes and reducing cannabis use

  This study tests if a medication called varenicline can help adults who smoke cigarettes and use cannabis quit smoking and cut down on cannabis use, with support from counseling and online resources.

  Recruiting Phase 3 Medical University of South Carolina · Charleston, South Carolina · NCT06883162

• Digital program to reduce depression and cannabis use

  This trial will test a digital program called AMP-C to see if it reduces depressive symptoms and cannabis use in adults with both major depression and problematic cannabis use.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT06878859

• Examining stress and pain in individuals living with HIV

  This study is testing how stress and pain affect people living with HIV, especially those who also struggle with substance use and depression, to see how these factors are connected.

  Recruiting Yale University · New Haven, Connecticut · NCT06784908

• Investigating how Pavlovian mechanisms influence substance use behaviors

  This study is testing how certain learned responses might affect substance use behaviors in people with moderate to severe substance use disorders compared to healthy individuals.

  Recruiting Technische Universität Dresden · Dresden · NCT06701487

• Effects of cannabidiol on cannabis concentrate users

  This study is testing if taking CBD can help regular cannabis concentrate users feel less cravings and use less of it over four weeks.

  Recruiting Phase 2 University of Colorado, Denver · Aurora, Colorado · NCT06575751

• Examining the effects of CBD on cannabis use in young adults

  This study is testing if CBD can help young adults who regularly use cannabis feel better and reduce the negative effects of their cannabis use.

  Recruiting Phase 2 University of Colorado, Denver · Aurora, Colorado · NCT06569394

• Effects of THC on alcohol consumption and brain reward mechanisms

  This study tests how taking a high dose of THC affects alcohol drinking and brain reward responses in people who use both substances.

  Recruiting Phase 2 University of Colorado, Denver · Aurora, Colorado · NCT06446479

• Integrated treatment to help adolescents recover from substance use disorders

  This study is testing a new combined therapy approach to help teenagers aged 14-21 recover from alcohol and cannabis use disorders and see if it works better than the standard treatment.

  Recruiting at 2 sites Massachusetts General Hospital · Farmington, Connecticut and 1 other locations · NCT06395467

• Intervention for cannabis use in young adults

  This study is testing two short programs to help young adults aged 18-25 who might be using cannabis too much, to see which one works better for them.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06395389

• Effects of cannabis abstinence on brain activity in adolescents with cannabis use disorder

  This study is testing how taking a break from cannabis for six weeks affects brain activity related to rewards in teenagers aged 15-18 who have cannabis use disorder and those who don’t.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06124846

• Treatment for Cannabis Use Disorder with Cannabidiol

  This study is testing if a hemp-based treatment with or without THC can help adults who regularly use cannabis reduce their use and improve their symptoms of cannabis use disorder.

  Recruiting Phase 2 University of Colorado, Boulder · Boulder, Colorado · NCT06107062

• Understanding genetics in cannabis use disorder and response to cannabinoids

  This study is testing how genetics affect the risk of cannabis use disorder and how people respond to a treatment with Delta-9-THC compared to a placebo.

  Recruiting Phase 1 Yale University · West Haven, Connecticut · NCT06058702

• Digital therapy for women with PTSD and cannabis use after sexual assault

  This study is testing a digital therapy to see if it can help women who have been sexually assaulted and are at risk for PTSD avoid developing problems with cannabis use.

  Recruiting at 2 sites Phase 1/2 University of Nevada, Las Vegas · Minneapolis, Minnesota and 5 other locations · NCT05989841

• Using guanfacine to help adolescents reduce cannabis use

  This study is testing if a medication called guanfacine can help young people aged 12 to 25 cut down on their cannabis use.

  Recruiting Phase 2 Orygen · Parkville, Victoria · NCT05957848

• Exploring cannabis use and stress in young adults

  This study is testing how cannabis affects stress management in young adults with cannabis use disorder to see if a cannabidiol solution can help them cope better.

  Recruiting Phase 1/2 Medical University of South Carolina · Charleston, South Carolina · NCT05885542

• Using magnetic stimulation to treat cannabis use disorder

  This study is testing if a new treatment using magnetic stimulation can help people with cannabis use disorder reduce their cannabis consumption and improve their overall well-being.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT05859347

• Assessing Patients with Alcohol and Cannabis Use Disorders

  This study is testing how a 12-week therapy program can help people with alcohol and cannabis use disorders by looking at how their thinking and feelings before treatment relate to their progress during therapy.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT05855668

• Rewards for abstaining from cannabis use

  This study is testing whether a rewards program or therapy is better at helping young people aged 16-22 quit using cannabis and stay abstinent over a year.

  Recruiting at 5 sites Parnassia Addiction Research Centre · Amsterdam and 4 other locations · NCT05836207

• Using virtual reality avatars to help reduce cannabis use in patients with psychotic disorders

  This study is testing if using virtual reality avatars can help people with psychotic disorders reduce their cannabis use more effectively than regular support.

  Recruiting Ciusss de L'Est de l'Île de Montréal · Montreal, Quebec · NCT05704582

• Investigating the effects of cannabis use and depression in young people living with HIV

  This study is looking at how using cannabis affects depression in young people with HIV to see if there are any patterns that could lead to worse health over a year.

  Recruiting University of Miami · Miami, Florida · NCT05453513

• Investigating cognitive function in psychosis patients and cannabis users

  This study is testing how taking a break from cannabis for 28 days affects thinking skills and brain activity in people with psychosis and those who use cannabis but don’t have mental health issues.

  Recruiting Douglas Mental Health University Institute · Montreal, Quebec · NCT05445180

NIH-funded research (25)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Hemp-derived CBD for reducing cannabis use in high-THC concentrate users

  A randomized, placebo-controlled trial tests whether hemp-derived CBD can help adults who mainly use high-potency cannabis concentrates reduce their cannabis use.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-11567759

• Varenicline for Cannabis Use Disorder in Men and Women

  A clinical trial will test if varenicline helps people with cannabis use disorder, with a focus on differences between men and women and added counseling to support craving and mood management.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11445421

• Cannabis Use Disorder and Opioid Health Risks in Veterans: A Long-Term VA Study

  A long-term study of veterans looking at how cannabis use disorder and its treatment relate to opioid-related health problems and hospital visits.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11415661

• One-session computerized program with text reminders to help manage distress and reduce cannabis use

  A short computer-delivered emotional skills session plus just-in-time text reminders to help people who use cannabis and struggle with handling distress learn to tolerate emotions and cut back on use.

  NIH research Florida State University · Tallahassee, United States · NIH-11399242

• Advancing Pregnenolone as a Therapy for Cannabis Use Disorder with Depression

  A study tests pregnenolone as a therapy for adults who have both cannabis use disorder and depression and aims to reduce cannabis use and improve mood.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11392064

• Cannabis use and HIV: how pot may affect aging and HIV outcomes

  A big study will look at how cannabis use and cannabis use disorder affect older people with HIV, including how it relates to aging problems and HIV treatment success.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11371946

• Hemp-derived CBD for helping people reduce high-potency cannabis use

  A clinical trial tests whether hemp-derived CBD can help adults reduce cannabis use and related withdrawal and mood symptoms when using high-potency cannabis concentrates.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-11361074

• Orexin blockers for cannabis withdrawal and use in a controlled inpatient study

  A study will test whether blocking orexin receptors with suvorexant helps people with cannabis use disorder manage withdrawal and reduce self‑ar mg behavior in a supervised inpatient setting.

  NIH research University of Kentucky · Lexington, United States · NIH-11337805

• Investigating new medications for cannabis use disorder.

  This study is looking for new medications to help people with cannabis use disorder by boosting the natural chemicals in the brain that can ease withdrawal symptoms and cravings, and it may involve patients trying out these new treatments to see how well they work and if they're safe.

  NIH research Makscientific, LLC · Burlington, United States · NIH-11264494

• Remote, patient-friendly program to help adults with cannabis use disorder access care

  A digital, video-based program using behavioral economics helps adults with cannabis use disorder get engaged in care from convenient locations.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11240433

• Understanding cannabis use and cannabis use disorder in adults with chronic pain

  This project is creating clearer ways to tell when adult cannabis use for chronic pain is helpful versus when it becomes a cannabis use disorder.

  NIH research Dartmouth College · Hanover, United States · NIH-11225957

• Exploring Hemp-Derived CBD to Help People with Cannabis Use Disorder

  This project looks at whether widely available hemp-derived CBD can help adults who use high-potency cannabis concentrates reduce their cannabis use and manage withdrawal symptoms.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-11128533

• Brain Stimulation and Training for Cannabis Use Disorder

  This project explores if a gentle brain stimulation combined with training can help people reduce their cannabis use.

  NIH research Yale University · New Haven, United States · NIH-11123332

• Brain Changes in Cannabis Use Disorder and Recovery

  This work looks at how cannabis use affects brain connections and if these connections can get better after someone stops using cannabis.

  NIH research Yale University · New Haven, United States · NIH-11099737

• Using hemp-derived cannabidiol to help people reduce cannabis use disorder

  This study is looking at whether CBD, a compound from hemp, can help people who are struggling with cannabis use, especially those using strong cannabis products, by comparing two types of CBD—one with a little THC and one without—to see if they can ease withdrawal symptoms and reduce overall cannabis use.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-11089903

• Understanding how stress affects cannabis use motivation in people with cannabis use disorder

  This study is looking at how stress affects the desire to use cannabis in people who struggle with cannabis use disorder, and it aims to find out how stress changes brain activity when they see things related to cannabis, which could help develop better treatments.

  NIH research Auburn University at Auburn · Auburn, UNITED STATES · NIH-11080949

• Using hemp-derived cannabidiol to help people reduce cannabis use

  This study is looking at how well hemp-derived CBD can help people who are having trouble with cannabis use, especially those using strong cannabis products, by comparing two types of CBD—one with a little THC and one without—to see which one helps reduce withdrawal symptoms and cannabis use.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-10925377

• Improving emotional coping skills for people with cannabis use disorder

  This study is testing a quick online program designed to help people with Cannabis Use Disorder learn to handle tough emotions better, and it includes helpful text reminders to keep you on track; by joining, you'll see if this approach can help you use less cannabis and feel more in control of your feelings.

  NIH research Auburn University at Auburn · Auburn, UNITED STATES · NIH-10894716

• Using brain stimulation and training to help reduce cannabis use

  This study is looking at whether a special brain stimulation technique, combined with training to help manage emotions, can support people who are trying to reduce their cannabis use, and it will involve 60 participants who will be checked on daily for a month to see how they’re doing.

  NIH research Yale University · New Haven, United States · NIH-10887016

• Investigating if brain changes from cannabis use improve after stopping use.

  This study is looking at how using cannabis might change the brain, especially a part called the hippocampus that helps with memory, and it wants to see if taking a break from cannabis for four weeks can help improve brain structure and memory in young adults and teens.

  NIH research Yale University · New Haven, United States · NIH-10886744

• How gender and hormones affect recovery from cannabis use disorder

  This study is looking at how gender and hormones affect how well people recover from cannabis use disorder, aiming to find better treatment options for both men and women.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-10844358

• Exploring a new treatment for Cannabis Use Disorder

  This study is testing a new medication called AEF0117 to see if it can help people who want to reduce their cannabis use, and it includes both animal tests and trials with volunteers to make sure it's safe and works well.

  NIH research New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · New York, United States · NIH-10668477

• Helping young adults with cannabis use disorder through text message support

  This study is looking at how young adults aged 18 to 25 who have trouble with cannabis use can get help through friendly text messages and peer support, making it easier and more private for them to manage their cannabis use and improve their lives.

  NIH research University of Tennessee Knoxville · Knoxville, United States · NIH-10618328

• Investigating new medications for cannabis use disorder.

  This study is looking for new medications to help people with cannabis use disorder by boosting natural chemicals in the brain that might ease withdrawal symptoms, and if you're interested, you could participate in trials to see how well these new treatments work and how safe they are.

  NIH research Makscientific, LLC · Burlington, United States · NIH-10577008

• New treatment for cannabis use disorder

  This study is working on a new pill to help people who have trouble with cannabis use, aiming to reduce cravings and make it easier to manage without serious side effects.

  NIH research Artiam Bio INC. · Cary, United States · NIH-10546566

Related topics

Quick answers

How many Cannabis Use Disorder clinical trials are recruiting right now?

30, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (20 trials), Canada (5 trials), Netherlands (1 trial), Australia (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Phase 1/2: 2, Phase 3: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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