Laboratory for Early Psychosis Research (LEAP) Center for Early Intervention
Official title: Laboratory for Early Psychosis Research (LEAP)
Funded at Mclean Hospital · NIH-11419731 · Data updated 2026-11-12
A nationwide program in Massachusetts aims to improve how first-episode psychosis is treated by testing new care approaches and using data to guide decisions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mclean Hospital NIH-funded |
| Lab location | 1 site (Belmont, United States) |
| Project start | May 15, 2019 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,951,130 |
| NIH project number | 5P50MH115846-08 |
| Project ID | NIH-11419731 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals experiencing a first episode of psychosis who are enrolled in or eligible for coordinated specialty care programs.
✕Less likely to help
Patients not in or accessible to coordinated specialty care may not directly benefit from these interventions.
What this research studies
This grant supports continuing a specialized center focused on early psychosis, with a statewide coordinated care system and advanced data methods. It plans a randomized trial to test enhanced coordinated specialty care and uses diverse data sources to study which treatments work best. The project emphasizes collaboration among clinicians, policymakers, data scientists, and patient communities to improve real-world care. It will develop and apply modern prediction and comparative effectiveness methods to guide treatment choices for people experiencing first-episode psychosis.
Why it matters
Potential benefit: If successful, patients with first-episode psychosis could receive more effective, personalized care earlier in their illness.
How similar studies have gone: Prior work with coordinated specialty care and CER approaches has shown promise, justifying larger, rigorously designed trials.
Where this research is happening
-
Mclean Hospital
Belmont, United States Active
Researchers
- Principal investigator: Ongur, Dost — Mclean Hospital
- Study coordinator: Ongur, Dost
Related research
Other NIH-funded projects on the same topics.
-
Psychosis in diverse settings across the world
This project studies how psychotic disorders show up and respond to treatment in adults with diverse backgrounds, including populations in Africa, the Caribbean, and other Global South settings.
-
Psychosis in Diverse Settings: Understanding Symptoms and Treatment Across Global South
A human-facing study will look at how psychotic disorders present and respond to treatment in adults from Africa, the Caribbean, and other Global South settings, using genetic and clinical data.
-
A new online brain-scan-style tool to spot early psychosis risk
A new online-based set of tasks and a computer model aims to identify people at high risk for developing psychosis earlier and more accurately.
-
Genetic clues for early-onset psychosis in Latino youth
This project looks at the genes of young people with early-onset psychosis and compares them with similar youths without psychosis to find genetic factors that contribute to the illness.
-
Biomarkers to tailor rehab for Veterans with schizophrenia
A clinician-scientist is developing a brain-based biomarker to guide personalized rehabilitation for Veterans with schizophrenia.
-
Computational analysis of facial expression in early psychosis
Aims to develop computer-based measures of facial expression in people at risk for or with schizophrenia to help track symptoms and guide future trials.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.