Biomarkers and Biotypes to Predict Early Psychosis Course in Bipolar Disorder
Official title: 1/5 - Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services (BICEPS)
Funded at Ut Southwestern Medical Center · NIH-11412655 · Data updated 2026-11-12
Researchers will use brain and cognitive markers to help predict how early psychosis in bipolar disorder patients will progress and what treatments might help best.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | August 15, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $287,000 |
| NIH project number | 5R01MH127179-05 |
| Project ID | NIH-11412655 on NIH RePORTER |
Who could benefit from this research
✓Could help
Young adults (approximately 18–35) with early psychosis who are enrolled in coordinated specialty care at participating sites.
✕Less likely to help
Individuals outside the age range, without early psychosis, or not receiving CSC services may not directly benefit.
What this research studies
This project will follow 320 young people with early psychosis who are receiving coordinated specialty care, collecting biomarkers such as EEG, eye movement data, and neurocognitive tests along with clinical information. The team will apply a biomarker-based Biotype classification previously developed in a larger psychosis sample to these patients and track their outcomes at 1, 6, and 12 months. By combining biomarker data with clinical and demographic factors, they aim to predict illness trajectory and tailor treatment plans within CSC clinics at five sites, including UT Southwestern. The work could help clinicians forecast who is likely to recover quickly, who may need more intensive intervention, and how to personalize care in the early stages of illness.
Why it matters
Potential benefit: If successful, patients could receive more precise and timely treatment plans that improve recovery and functioning.
How similar studies have gone: Biotype-based biomarker approaches have been replicated in broader psychosis samples, supporting potential applicability to early-stage cases.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Tamminga, Carol a — Ut Southwestern Medical Center
- Study coordinator: Tamminga, Carol a
Related research
Other NIH-funded projects on the same topics.
-
Psychosis in diverse settings across the world
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-
Psychosis in Diverse Settings: Understanding Symptoms and Treatment Across Global South
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-
A new online brain-scan-style tool to spot early psychosis risk
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Biomarkers to tailor rehab for Veterans with schizophrenia
A clinician-scientist is developing a brain-based biomarker to guide personalized rehabilitation for Veterans with schizophrenia.
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Computational analysis of facial expression in early psychosis
Aims to develop computer-based measures of facial expression in people at risk for or with schizophrenia to help track symptoms and guide future trials.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.