Neurodevelopment and Psychosis in 22q11.2 Deletion Syndrome
Official title: Neurodevelopment and Psychosis in the 22q11.2 Copy Number Variants
Funded at University of California Los Angeles · NIH-11404798 · Data updated 2026-11-12
A long-term study follows people with 22q11.2 deletions to understand how genetic risk leads to brain and behavior changes over time, with the goal of identifying early clues for psychosis.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | December 14, 2009 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $724,543 |
| NIH project number | 5R37MH085953-14 |
| Project ID | NIH-11404798 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals aged adolescence to early adulthood who have a diagnosed 22q11.2 deletion/duplication and are willing to participate in long-term follow-up.
✕Less likely to help
Individuals without a 22q11.2 CNV or not interested in long-term participation may not benefit.
What this research studies
This project enrolls individuals with the 22q11.2 deletion and tracks their development over several years to uncover early biomarkers and biological pathways linked to psychosis. By studying genetics first, researchers hope to see how brain development unfolds differently in this group and how related genes contribute to risk. The study uses longitudinal assessments, neuroimaging, and biological samples to map how early vulnerability evolves into neuropsychiatric outcomes. Findings could guide earlier interventions and inform families about prognosis and care needs.
Why it matters
Potential benefit: If successful, it could lead to earlier detection and targeted strategies to reduce risk or improve outcomes for people with 22q11.2 deletions.
How similar studies have gone: Prior work shows promise in linking 22q11.2 CNVs with neuropsychiatric risk, with ongoing longitudinal insight expected from this study.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Bearden, Carrie E — University of California Los Angeles
- Study coordinator: Bearden, Carrie E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.