Biomarkers and Early Psychosis Trajectories in Bipolar Disorder and Related Conditions
Official title: 2/5 Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services (BICEPS)
Funded at University of Chicago · NIH-11408526 · Data updated 2026-11-12
This grant tests whether biomarker-based groups can predict how young people with early psychosis will fare in coordinated specialty care to tailor treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | August 15, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $275,618 |
| NIH project number | 5R01MH127162-05 |
| Project ID | NIH-11408526 on NIH RePORTER |
Who could benefit from this research
✓Could help
Young adults (roughly late teens to mid-30s) with bipolar disorder or related psychotic conditions receiving coordinated specialty care.
✕Less likely to help
Patients outside the early psychosis window or not receiving CSC care may not benefit from this biomarker-based approach.
What this research studies
The project follows young people with early-course psychosis across multiple clinics to see if EEG, eye movement, and cognitive measurements, together with clinical data, can forecast outcomes over 1, 6, and 12 months. Using a pre-established biomarker classification (Biotypes 1, 2, and 3) found in a trans-diagnostic sample, researchers will characterize how these groups relate to recovery, stability, or decline. The study analyzes real patient data from CSC clinics to improve personalized treatment planning and resource use. Participants will receive standard CSC care while researchers observe and analyze their trajectories and biomarker profiles.
Why it matters
Potential benefit: If successful, clinicians could use biomarker-biotype information to personalize treatment plans and improve outcomes for young people with early psychosis.
How similar studies have gone: Previous BSNIP-based biomarkers have been validated in trans-diagnostic samples, supporting potential applicability in early psychosis.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Gershon, Elliot S — University of Chicago
- Study coordinator: Gershon, Elliot S
Related research
Other NIH-funded projects on the same topics.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.