Understanding and tracking early signs of psychosis
ProNET: Psychosis-Risk Outcomes Network
This project follows people with early warning signs of psychosis to find brain, behavioral, genetic, and digital markers that help predict future outcomes.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11493634 on NIH RePORTER |
What this research studies
You would join an international network that follows people who have early or mild psychotic symptoms over two years. Researchers collect brain scans (MRI), EEG, genetic tests, blood and other body samples, speech recordings, cognitive tests, and smartphone sensor and survey data at multiple visits. About 1,040 people at clinical high risk and 260 healthy volunteers take part across 26 sites, with key measurements repeated to track changes over time. The team links these markers to clinical courses to help guide who might need different treatments.
Who could benefit from this research
Good fit: Ideal candidates are people showing early or attenuated psychotic symptoms (clinical high risk) who can attend repeated visits and complete scans, tests, and smartphone-based monitoring.
Not a fit: People without early warning signs of psychosis, those already diagnosed with a full psychotic disorder, or those unable to complete in-person visits or digital monitoring may not receive direct benefit.
Why it matters
Potential benefit: If successful, this could help doctors identify who is most likely to develop full psychosis sooner and tailor earlier, more effective treatments.
How similar studies have performed: Previous smaller studies have found some promising markers, but this large, multi-site, multimodal approach is broader and less tested at this scale.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Woods, Scott W — Yale University
- Study coordinator: Woods, Scott W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.