Biomarkers and Biotypes to Predict Early Psychosis Outcomes in Bipolar Disorder
Official title: Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services (BICEPS)
Funded at Beth Israel Deaconess Medical Center · NIH-11417173 · Data updated 2026-11-12
This study uses brain-related biomarkers and clinical data to predict how early psychosis will progress in people with bipolar disorder undergoing specialized care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $198,136 |
| NIH project number | 5R01MH127174-05 |
| Project ID | NIH-11417173 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with bipolar disorder experiencing early psychosis who are receiving coordinated specialty care at CSC clinics in the BSNIP network.
✕Less likely to help
Patients outside the early psychosis window or not receiving CSC services may not directly benefit from this study.
What this research studies
If you’re in the early stages of psychosis and receiving coordinated specialty care, researchers will look at EEG, eye movements, and cognitive tests along with clinical information to identify illness patterns. They’ll group patients into Biotypes and track outcomes at 1, 6, and 12 months to see which factors best forecast recovery or decline. The goal is to tailor treatment plans more precisely based on combined biomarker and clinical profiles. The study will involve about 320 participants across five sites, with careful follow-up to understand how trajectories unfold.
Why it matters
Potential benefit: If successful, this work could help doctors predict who is most likely to improve and personalize treatment plans for early psychosis in bipolar disorder.
How similar studies have gone: Prior work in trans-diagnostic psychosis has shown promising Biotype-based grouping, with ongoing validation in early stages.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Keshavan, Matcheri S. — Beth Israel Deaconess Medical Center
- Study coordinator: Keshavan, Matcheri S.
Related research
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Psychosis in Diverse Settings: Understanding Symptoms and Treatment Across Global South
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.