Biomarkers and Biotypes in Early Psychosis for Bipolar Disorder and Related Conditions
Official title: 3/5 Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services (BICEPS)
Funded at Yale University · NIH-11417147 · Data updated 2026-11-12
This project uses biomarker-based brain patterns and clinical data to predict outcomes for people with early psychosis and bipolar disorder who receive specialized care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 15, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $162,725 |
| NIH project number | 5R01MH127158-05 |
| Project ID | NIH-11417147 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals aged 18-35 with early psychosis or bipolar disorder with psychosis enrolled in coordinated specialty care.
✕Less likely to help
Patients outside the early psychosis window or not receiving CSC services may not benefit from this study.
What this research studies
If you have bipolar disorder with psychotic features and are in coordinated specialty care, this research will look at EEG, eye movement, and cognitive data collected early in illness to see how well they predict how the illness will progress over 1, 6, and 12 months. The study uses existing biomarker-based categories (Biotypes) previously identified in a broader psychosis group and applies them to young adults in CSC settings across multiple sites. By combining biomarker data with clinical information, researchers aim to identify distinct illness trajectories so care can be better tailored. Participants will contribute data during follow-up visits at CSC clinics, helping clinicians foresee course and adjust treatment plans accordingly.
Why it matters
Potential benefit: If successful, results could help doctors personalize treatment and improve long-term outcomes for people with early psychosis and bipolar-related psychosis.
How similar studies have gone: Previous BSNIP work showed that biomarker-based Biotypes can categorize psychosis; applying this to early psychosis is a novel but building on successful biomarker approaches.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Pearlson, Godfrey D — Yale University
- Study coordinator: Pearlson, Godfrey D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.