Condition

PTSD clinical trials and research

• 98Clinical trials
• 272NIH research projects
• 11Countries

Newest PTSD clinical trials

All recruiting trials (98)

• Hyperbaric Oxygen Therapy for Veterans With TBI and PCS

  This study tests whether 40 HBOT sessions can change blood biomarkers in veterans with traumatic brain injury and persistent symptoms, and whether PTSD affects those biomarker changes.

  Recruiting Phase 2 Summit Hyperbarics and Wellness · Boise, Idaho · NCT07849465

• Internet-delivered ACT for youth with PTSD and chronic pain

  A small pilot study will test a web-based Acceptance and Commitment Therapy program for teens and young adults with PTSD and chronic pain to see if it helps with symptoms and functioning.

  Recruiting Skane University Hospital · Lund · NCT07813728

• Reboxetine plus Ritalin vs Dog-Assisted Therapy for PTSD

  This study tests whether a drug combo of reboxetine and methylphenidate works better than dog-assisted therapy for people with PTSD.

  Recruiting Phase 2 University of Haifa · Haifa · NCT07771530

• Floatation-REST for frontline workers with post-traumatic stress symptoms

  This early pilot tests whether two 60-minute Floatation-REST sessions can be safely tried by frontline healthcare workers and first responders who have post-traumatic stress symptoms, compared to watching a documentary.

  Recruiting Early Phase 1 Laureate Institute for Brain Research, Inc. · Tulsa, Oklahoma · NCT07710417

• Short-Term Intensive PTSD Treatment for Military Personnel

  This trial tests whether a brief, massed form of CPT and EMDR can quickly reduce PTSD symptoms and related cognitive problems in active-duty military personnel.

  Recruiting Ohio State University · Fayetteville, North Carolina · NCT07680517

• Exposure by Assessment: Testing AMQ-based EMA on Intrusive Trauma Memories in PTSD

  We’re testing whether daily prompts to focus on a traumatic memory (vs. a neutral memory) using a simple at-home EMA can reduce intrusive PTSD memories and overall PTSD symptoms.

  Recruiting Tel Aviv University · Tel Aviv · NCT07658157

• Hybrid DBT for Veterans to Further Reduce PTSD and Emotion Regulation Problems

  This study tests a hybrid dialectical behavior therapy program for veterans with PTSD and emotion regulation issues to see if it helps reduce symptoms and improve daily functioning.

  Recruiting Arkin · Amstelveen, North Holland · NCT07652645

• COMP360 psilocybin for PTSD: see if it helps reduce symptoms with guided support

  This study tests COMP360 (a lab-made psilocybin) to see if it can help reduce PTSD symptoms in adults, with supervision from a trained team.

  Recruiting at 17 sites Phase 2/3 COMPASS Pathways · Tucson, Arizona and 16 other locations · NCT07570654

• Temporal Interference Neuromodulation for Anxiety and PTSD

  Aimed at seeing whether temporal interference neuromodulation can help people with anxiety or PTSD by using scalp electrodes and brain imaging to monitor mood, physiology, and cognition.

  Recruiting Emory University · Atlanta, Georgia · NCT07558759

• Exercise to boost fear extinction in people with PTSD

  This trial tests whether moderate aerobic exercise done during or after extinction learning can help adults with PTSD reduce later fear responses.

  Recruiting University of Texas at Austin · Austin, Texas · NCT07548125

• Non-invasive vagus nerve stimulation (gammaCore) for PTSD

  This study will test whether the handheld gammaCore device, which delivers mild electrical stimulation to the vagus nerve through the neck, can help adults with PTSD reduce their symptoms.

  Recruiting Acacia Clinics · Sunnyvale, California · NCT07523685

• Group psilocybin-assisted therapy for PTSD

  This trial will try group psilocybin-assisted therapy to see if it helps adults with moderate to severe PTSD, including veterans, first responders, female survivors of sexual violence, and Indigenous people.

  Recruiting Phase 1 University of New Mexico · Albuquerque, New Mexico · NCT07506395

• HB-1 for PTSD: testing safety and efficacy vs placebo in adults 18-65

  This study tests whether HB-1 helps reduce PTSD symptoms in adults aged 18–65 compared with a placebo.

  Recruiting at 16 sites Phase 2 HB BioTech, LLC · Deakin, Australian Capital Territory and 15 other locations · NCT07499440

• Bilateral cervical sympathetic blocks with optional integrative therapy for Special Operations veterans with PTSD and trauma-related symptoms

  This project will try bilateral cervical sympathetic blocks (BCSB), with or without added structured integrative therapy, to see if they reduce PTSD, TBI, and other trauma-related symptoms in Special Operations veterans.

  Recruiting Reset Medical and Wellness Center · Strongsville, Ohio · NCT07473505

• Group versus individual MDMA-assisted therapy for PTSD related to the October 7, 2023 events

  The study will see if group-based MDMA-assisted therapy works as well and is as safe as individual MDMA-assisted therapy for adults diagnosed with PTSD after October 7, 2023.

  Recruiting at 2 sites Phase 2 Sheba Medical Center · Beersheba and 1 other locations · NCT07469098

• Oral estradiol to reduce intrusive memories after trauma film

  This trial will test whether a single 3 mg dose of oral estradiol valerate reduces intrusive memories in healthy adult women after viewing a trauma film.

  Recruiting Charite University, Berlin, Germany · Berlin, State of Berlin · NCT07419594

• Behavioral health collaborative care for family members of ICU survivors in the Post-ICU clinic pilot

  This pilot tests a telehealth-based behavioral health program using the NeuroFlow app for family members of ICU survivors to try to reduce anxiety, depression, and PTSD symptoms.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07390786

• Cervical Plexus Dextrose Injection vs Saline for Treatment-Resistant PTSD

  This trial tests whether a D5W injection around the neck nerves helps reduce PTSD symptoms in people who haven’t responded to other treatments, compared with normal saline.

  Recruiting at 3 sites Phase 4 Dr. Dean Reeves Clinic · Lexington, Kentucky and 3 other locations · NCT07382596

• Behavioral health collaborative care for people recovering after ICU

  This trial will test whether a coordinated behavioral health program using a digital app, coaching, and psychiatric support helps ICU survivors reduce anxiety, depression, and PTSD symptoms.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07372586

• Non‑trauma PTSD treatment for veterans and service members with mild or moderate TBI

  This pilot will test a non‑trauma psychotherapy program to help veterans and service members with mild or moderate traumatic brain injury who have PTSD.

  Recruiting The University of Texas Health Science Center at San Antonio · Fort Hood, Texas · NCT07351305

• Psilocybin-assisted therapy for PTSD in veterans

  This pilot test will try psilocybin with psychotherapy to see if it helps reduce PTSD symptoms in military veterans and service members.

  Recruiting Phase 2 Emory University · Atlanta, Georgia · NCT07332143

• Group-based Metacognitive Therapy for PTSD in routine psychiatric care.

  This project will try group-based Metacognitive Therapy (MCT) for adults with PTSD to see if people accept the treatment and whether symptoms and quality of life improve when it is offered in routine psychiatric care in Sweden.

  Recruiting Karolinska Institutet · Stockholm · NCT07302334

• Group Cognitive Processing Therapy (CPT) for incarcerated adults with PTSD

  This project will try group Cognitive Processing Therapy (CPT) with incarcerated adults who have PTSD to see if it reduces PTSD symptoms and disciplinary incidents.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT07283757

• Exercise to lower heart and artery risk in people with PTSD

  This project will test whether a supervised exercise program can change brain activity and reduce artery inflammation in adults with PTSD who have or are at risk for atherosclerotic cardiovascular disease.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT07260032

• Combined treatment for PTSD and chronic pain

  This project will try a combined therapy that treats PTSD and long-term pain at the same time for adults who have both conditions.

  Recruiting Weill Medical College of Cornell University · New York, New York · NCT07225049

• LGBTQ+-affirming virtual therapy combining CBT and expressive writing for trauma and alcohol use

  This study will test a brief, virtual LGBTQ+-affirming therapy that combines cognitive behavioral techniques and expressive writing to see if it helps LGBTQ+ adults with PTSD and problematic alcohol use.

  Recruiting University of Rhode Island · Providence, Rhode Island · NCT07217795

• VR Fear Conditioning with Brain and Bodily Response in RNS-treated Epilepsy/PTSD

  This study tests how people with an implanted RNS device respond to fear-related cues in a virtual reality setting to see how brain and body signals relate to fear learning.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT07216222

• Video support for teens and families after a traumatic injury

  This project tests short video interventions for hospitalized teens and their parents to see if they reduce PTSD symptoms and future substance use after a traumatic injury.

  Recruiting Rhode Island Hospital · Providence, Rhode Island · NCT07197476

• ECCCLORE group program for people with addiction and trauma-related PTSD

  This program will try a group-based ECCCLORE therapy to see if it helps people who have addiction and PTSD or complex PTSD reduce substance use and impulsive or hostile behaviors.

  Recruiting Centre Hospitalier Universitaire de Nīmes · Nîmes, Nîmes · NCT07193914

• Adaptive, personalized PTSD care for veterans

  This program will try different therapy sequences plus optional text-message homework reminders to see if switching treatments or sending prompts helps veterans with PTSD who aren't improving or are missing between-session homework.

  Recruiting at 3 sites The University of Texas Health Science Center at San Antonio · Augusta, Georgia and 3 other locations · NCT07176273

• Integrated PTSD and weight-management program for Veterans with obesity.

  This program will test whether combining PTSD therapy with behavioral and medication-supported weight management helps Veterans with PTSD and obesity lose weight and reduce PTSD symptoms.

  Recruiting VA Office of Research and Development · Seattle, Washington · NCT07010757

• Optimizing therapy components for pediatric PTSD with a multiphase design

  This project will try different therapy pieces to see which combinations help children and teens (ages 8–17) with PTSD feel better.

  Recruiting University of Rochester · Rochester, New York · NCT06956781

• Trauma, PTSD, and resilience in adults living with congenital heart disease

  This project will test whether lifetime experiences related to congenital heart disease are linked to PTSD and whether resilience helps protect adults with CHD.

  Recruiting Dartmouth-Hitchcock Medical Center · Washington D.C., District of Columbia and 2 other locations · NCT06952933

• Training for better emotion regulation in PTSD patients

  This study is testing a new online training program to see if it can help adults with PTSD manage their emotions better and reduce their symptoms.

  Recruiting Tel Aviv University · Tel Aviv · NCT06943560

• Psilocybin-assisted therapy for PTSD after sexual assault

  This trial will test whether a single 25 mg oral dose of psilocybin combined with therapy helps cisgender women who have PTSD from a sexual assault.

  Recruiting Phase 2 Sunstone Medical · Rockville, Maryland · NCT06902974

• New psychotherapy for PTSD and depression after sexual assault

  This study is testing a new short therapy session to see if it can help college students who have experienced sexual assault feel better by reducing their PTSD and depression symptoms.

  Recruiting Case Western Reserve University · Cleveland, Ohio · NCT06900712

• Assessing the effects of psilocybin therapy on PTSD in veterans

  This study is testing whether psilocybin therapy can help U.S. military veterans with PTSD feel better and recover from their trauma.

  Recruiting Phase 2 Baylor College of Medicine · Houston, Texas · NCT06888128

• Counseling intervention to improve firearm storage for those with PTSD

  This study is testing a counseling program to see if it can help people with PTSD store their firearms more safely to reduce the risk of suicide.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT06876740

• Help for caregivers and children to speed emotional recovery after serious pediatric injury

  This project will test CAARE, a technology-assisted, stepped-care program, to help children under 12 hospitalized for serious injuries and their caregivers recover emotionally compared with enhanced usual care.

  Recruiting at 4 sites Medical University of South Carolina · Los Angeles, California and 3 other locations · NCT06856057

• Short-term therapy for PTSD symptoms

  This study is testing a week-long therapy to see if it can help adults with PTSD feel better and reduce their symptoms.

  Recruiting Ben-Gurion University of the Negev · Beersheba · NCT06826937

• Orexin-blocking treatment to help fear extinction in PTSD and insomnia

  This study tests whether suvorexant, a sleep medication that blocks orexin receptors, helps people with PTSD and insomnia by improving fear extinction learning.

  Recruiting Phase 4 VA Office of Research and Development · San Francisco, California and 1 other locations · NCT06788522

• Improving mental health support for refugees through a psychological intervention

  This study is testing a new way to help refugees and asylum seekers with their mental health by improving a support program that includes extra sessions and reminders to see if it makes a difference.

  Recruiting University of Zurich · Zurich · NCT06776523

• Improving PTSD treatment through patient engagement strategies

  This study is testing if adding extra support like motivation sessions and shared decision-making can help people with PTSD stick with their treatment and feel better compared to standard care.

  Recruiting Herlev and Gentofte Hospital · Ballerup Municipality, Capital Region · NCT06755710

• Augmented reality-enhanced exposure therapy for PTSD in U.S. military personnel

  This tests whether adding augmented reality to standard exposure therapy helps U.S. military veterans and active-duty adults with PTSD.

  Recruiting Wayne State University · Charleston, South Carolina · NCT06740487

• Impact of a psycho-education program for victims of sexual violence

  This study tests a group program for victims of sexual violence to see if it helps improve their mental health and reduce PTSD symptoms.

  Recruiting Centre Hospitalier Charles Perrens, Bordeaux · Bordeaux · NCT06718387

• Deep Brain Stimulation for Patients with Severe PTSD

  This study is testing if a surgery that uses deep brain stimulation can help people with severe PTSD who haven't found relief from other treatments.

  Recruiting Phase 1 Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT06705296

• Working memory training to improve fear extinction in veterans with PTSD

  This study is testing if a special memory training program can help veterans with PTSD learn to manage their fears better.

  Recruiting VA Office of Research and Development · San Diego, California · NCT06629064

• Improving rehabilitation for veterans with serious mental illness

  This study is testing a new computer program to help veterans with serious mental illnesses improve their thinking and daily life skills.

  Recruiting VA Office of Research and Development · San Diego, California · NCT06586164

• EEG‑guided propofol to induce dreaming as a therapy for PTSD

  This trial will test whether EEG‑guided propofol anesthesia that induces dreaming can reduce symptoms in adults with PTSD.

  Recruiting Phase 2 Stanford University · Stanford, California · NCT06577636

• Combined CPT and Stellate Ganglion Block for PTSD in Adults

  This study tests whether adding Stellate Ganglion Block to Cognitive Processing Therapy helps reduce PTSD symptoms more than CPT with placebo or SGB with daily monitoring.

  Recruiting Early Phase 1 Rush University Medical Center · Chicago, Illinois · NCT06570213

• Screening for PTSD in Pregnant Black Women

  This study tests which method works better to screen for PTSD in Black pregnant women and improve their health during pregnancy.

  Recruiting at 2 sites Emory University · Atlanta, Georgia and 1 other locations · NCT06522022

• Patient outcome reporting to speed PTSD diagnosis and care on Chicago's South Side

  This project will try using patient portal outreach plus screening during primary care visits to find and connect adults with PTSD at two Chicago community health centers.

  Recruiting at 2 sites University of Chicago · Chicago, Illinois and 1 other locations · NCT06479447

• Modulating gut microbiome with prebiotics in veterans with PTSD and cirrhosis

  This study is testing if giving prebiotics can help improve gut health and overall well-being in veterans who have both PTSD and liver disease.

  Recruiting Hunter Holmes Mcguire Veteran Affairs Medical Center · Richmond, Virginia · NCT06464952

• Psilocybin treatment for individuals with various psychiatric symptoms

  This study is testing if a single dose of psilocybin can help people with different mental health issues like depression, anxiety, and PTSD feel better and improve their daily functioning.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT06442423

• Outpatient ketamine infusion for chronic pain and PTSD in military personnel

  This study is testing if ketamine infusions can help military personnel with chronic pain and PTSD feel better compared to those who only receive magnesium.

  Recruiting Phase 4 Brooke Army Medical Center · San Antonio, Texas · NCT06414356

• Comparing PTSD treatments for LGBTQIA+ individuals

  This study is testing whether Cognitive Processing Therapy or STAIR Narrative Therapy works better to help LGBTQIA+ adults with PTSD feel better and improve their quality of life.

  Recruiting at 2 sites Stanford University · Palo Alto, California and 1 other locations · NCT06367764

• Using retinal biomarkers to predict mental health treatment outcomes in PTSD

  This study is testing if changes in eye signals can help predict how well veterans with PTSD will respond to a single dose of the medication sertraline.

  Recruiting VA Puget Sound Health Care System · Seattle, Washington · NCT06363968

• Trauma-adapted yoga for adolescents with ADHD and PTSD

  This study is testing whether an eight-week trauma-adapted yoga program can help teenagers with ADHD and PTSD feel better and improve their quality of life.

  Recruiting University West, Sweden · Gothenburg · NCT06330779

• Evaluating the H.O.O.V.E.S. Healing Intensives Program for Veterans

  This study is testing if the H.O.O.V.E.S. Healing Intensives Program can help veterans with anxiety, PTSD, and depression feel better over time.

  Recruiting VA Salt Lake City Health Care System · Salt Lake City, Utah · NCT06300255

• Improving treatment for suicidal individuals with PTSD

  This study is testing if combining prolonged exposure therapy with a crisis response plan can help people with PTSD reduce their suicidal thoughts and behaviors better than standard treatment.

  Recruiting Ohio State University · Columbus, Ohio · NCT06285708

• A Deaf-accessible therapy toolkit for treating alcohol use disorder and trauma

  This study is testing a new therapy toolkit designed for Deaf individuals to see if it helps them better manage alcohol use disorder and trauma compared to standard treatment and no treatment at all.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT06278922

• Parenting STAIR for military-connected mothers and their young children

  This study tests whether a 12–16 week online Parenting STAIR program helps military-connected mothers with trauma reduce PTSD or depression symptoms and improve parenting with their 2–10-year-old children.

  Recruiting at 3 sites New York University · El Paso, Texas and 2 other locations · NCT06262178

• Peer-led family support intervention for refugee families

  This study tests a new support program led by peers to help refugee families in Chicago improve their mental health and strengthen their family connections.

  Recruiting University of Illinois Chicago · Chicago, Illinois · NCT06261463

• Prolonged Exposure Therapy for PTSD in Trauma Patients

  This study is testing a short therapy called Brief Prolonged Exposure Therapy to see if it can help trauma patients avoid PTSD and improve their mental health after serious injuries.

  Recruiting at 3 sites Baylor Research Institute · Dallas, Texas and 2 other locations · NCT06210711

• Biobank for studying ALS and Alzheimer's diseases

  This study is collecting blood, skin samples, and health information from people to see how genetics might help us understand and find treatments for ALS and Alzheimer's disease.

  Recruiting New York Stem Cell Foundation Research Institute · New York, New York · NCT06203106

• Aerobic exercise's effect on fear extinction in PTSD

  This study is testing if doing aerobic exercise after learning to overcome fear can help people with and without PTSD remember that fear better.

  Recruiting University of Alabama, Tuscaloosa · Tuscaloosa, Alabama · NCT06144203

• Effects of exercise on learning and memory in PTSD

  This study tests if moderate exercise can help improve learning and memory in adults with PTSD from interpersonal violence to see if it leads to better symptom relief.

  Recruiting at 2 sites University of Kentucky · Lexington, Kentucky and 1 other locations · NCT06127342

• Effects of psychotherapy on brain function in PTSD

  This study is testing whether trauma-focused therapy can change how the brain processes rewards in people with chronic PTSD to see if it helps them feel more positive emotions.

  Recruiting University of Texas at Austin · Austin, Texas · NCT06096740

• Trauma therapy for patients with PTSD and psychotic disorders

  This study is testing if a specific trauma therapy can help people with both PTSD and psychotic disorders feel better over time.

  Recruiting Medicalschool Hamburg · Hamburg · NCT06048172

• Self-management support for patients after receiving an ICD shock

  This study is testing a new support program for people who have just received a shock from their ICD to see if it can help reduce anxiety and improve their quality of life.

  Recruiting University of Washington · Seattle, Washington · NCT06037785

• Sensory Motor Arousal Regulation Treatment (SMART) for PTSD

  We will try a movement- and body-based therapy called SMART to help adults with PTSD.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT06035809

• Workshop to help recently transitioned Veterans reduce suicide risk and improve reintegration

  This study is testing a workshop designed to help Veterans transitioning to civilian life reduce their risk of suicide and improve their reintegration by teaching them practical skills and providing support.

  Recruiting VA Office of Research and Development · Boston, Massachusetts · NCT05995678

• MDMA-assisted therapy for veterans with severe PTSD

  This study is testing whether therapy combined with MDMA can help veterans with severe PTSD feel better compared to standard therapy alone.

  Recruiting Phase 2 Palo Alto Veterans Institute for Research · Palo Alto, California · NCT05837845

• Web-based training program for providers treating PTSD and substance use disorders

  This study is testing a new online training program for healthcare providers to help them better treat military Veterans who have both PTSD and substance use disorders.

  Recruiting VA Office of Research and Development · Charleston, South Carolina · NCT05812131

• Blended treatment for PTSD using computer-assisted therapy

  This study is testing a new blended therapy for PTSD that combines online and in-person sessions to see if it works as well as the usual face-to-face treatment.

  Recruiting Karolinska Institutet · Stockholm · NCT05758987

• Parent-led treatment for children with trauma symptoms

  This study is testing a new parent-led treatment for children aged 7-12 with trauma symptoms to see if it helps them feel better compared to regular care.

  Recruiting at 2 sites Norwegian Center for Violence and Traumatic Stress Studies · Asker and 1 other locations · NCT05734547

• Preventing chronic pain by treating PTSD during acute pain episodes

  This study is testing if treating PTSD symptoms during episodes of acute pain can help prevent people from developing chronic pain later on.

  Recruiting Rush University Medical Center · Chicago, Illinois · NCT05700279

• Using brain imaging to improve treatment for PTSD with TMS

  This study is testing if brain scans can help improve a treatment called rTMS for people with PTSD by finding out how it affects their brain.

  Recruiting Palo Alto Veterans Institute for Research · Palo Alto, California · NCT05646732

• Investigating neuromuscular blockers in mechanically ventilated patients

  This study is testing how different muscle relaxants affect patients on ventilators in emergency departments to see if they improve outcomes and reduce complications.

  Recruiting at 4 sites Washington University School of Medicine · Iowa City, Iowa and 3 other locations · NCT05534243

• Treatment for PTSD in pregnant women

  This study is testing if a writing therapy for PTSD can help pregnant women feel better when it's given by community health workers compared to mental health professionals.

  Recruiting Boston University · Boston, Massachusetts · NCT05486793

• Improving PTSD treatment outcomes using adaptive therapy approaches

  This study tests if using a flexible approach to therapy for PTSD, starting with simpler treatments and adjusting based on how patients respond, can lead to better results.

  Recruiting at 12 sites University of Michigan · Baldwin, Michigan and 12 other locations · NCT05457985

• Understanding brain changes during therapy for adolescent PTSD

  This study is trying to see how trauma-focused therapy changes the brains of teenagers with PTSD to help improve their treatment.

  Recruiting The University of Texas Health Science Center at San Antonio · San Antonio, Texas · NCT05423444

• Using art therapy to improve emotional well-being in military personnel with PTSD

  This study tests whether art therapy can help military personnel with PTSD feel better emotionally and improve their mental health.

  Recruiting at 2 sites Walter Reed National Military Medical Center · Bethesda, Maryland and 1 other locations · NCT05414708

• Comparing telehealth and in-person training for veterans with brain injuries and PTSD

  This study tests whether veterans with brain injuries and PTSD can benefit just as much from online training as they do from in-person training to improve their attention and problem-solving skills.

  Recruiting VA Office of Research and Development · Gainesville, Florida · NCT05380050

• Using targeted TMS to improve fear extinction in PTSD patients

  This study is testing how different ways of using a brain stimulation technique called TMS can help people with PTSD manage their fear better.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT05368987

• Improving memory support in PTSD therapy

  This study is testing whether adding memory support techniques to therapy can help people with PTSD remember and benefit more from their treatment.

  Recruiting Boston University · Jamaica Plain, Massachusetts · NCT05310097

• Using CBD to treat PTSD symptoms in adults

  This study is testing whether CBD can help adults with PTSD feel better and improve their quality of life.

  Recruiting Phase 2 University of Nebraska · Omaha, Nebraska · NCT05269459

• Comparing two treatments for insomnia in veterans with PTSD

  This study is trying out a new treatment for insomnia that combines different therapy techniques to see if it helps veterans with PTSD sleep better and feel less anxious compared to standard therapy.

  Recruiting VA Office of Research and Development · Sepulveda, California and 1 other locations · NCT05194930

• Internet-delivered therapy for PTSD and chronic pain

  This study is testing whether online therapy can help people with PTSD and chronic pain feel better compared to those who wait to start the treatment.

  Recruiting Skane University Hospital · Lund · NCT05147948

• Understanding brain activity related to fear and anxiety

  This study is trying to understand how the brain reacts to fear and anxiety in people with conditions like PTSD and GAD by monitoring their brain activity and emotions during different tasks, including virtual reality experiences.

  Recruiting at 2 sites Duke University · Los Angeles, California and 1 other locations · NCT05120635

• Treating pediatric PTSD with memory reactivation and propranolol

  This study is testing if giving children with PTSD a medication called propranolol along with special memory exercises can help lessen the emotional pain from their traumatic memories.

  Recruiting Phase 3 University Hospital, Toulouse · Toulouse · NCT04985344

• Using low-dose clonidine to treat PTSD in veterans

  This study is testing if a low dose of clonidine can help veterans with PTSD feel better and improve their sleep and daily activities.

  Recruiting Phase 3 Wake Forest University Health Sciences · Wauwatosa, Wisconsin · NCT04877093

• Program to help mothers with PTSD and improve parenting skills

  This study is testing a new program to help mothers with PTSD improve their parenting skills and reduce the risk of harming their children.

  Recruiting New York University · New York, New York · NCT04752618

• Improving therapeutic learning for PTSD in women

  This study is testing whether a medication that affects dopamine can help women with PTSD from physical or sexual assault feel less fear during therapy.

  Recruiting Phase 2 University of Wisconsin, Madison · Austin, Texas and 1 other locations · NCT04558112

• Observational study on integrative medical care for chronic illnesses and mental health

  This study is testing how a team approach to integrative medical care can help adults and children with chronic illnesses and mental health issues feel better.

  Recruiting Advanced Integrative Medical Science Institute · Seattle, Washington · NCT04512755

• Therapeutic treatment for PTSD using Deep Brain Reorienting

  This study is testing a new treatment called Deep Brain Reorienting to see if it can help people with PTSD manage their symptoms better.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT04317820

• Comparing two therapies for PTSD in military personnel

  This study tests whether two different therapies for PTSD, Exposure Therapy and Interpersonal Psychotherapy, work equally well for military personnel who have experienced Military Sexual Trauma.

  Recruiting Weill Medical College of Cornell University · New York, New York · NCT03803332

• Psychodynamic psychotherapy for veterans with PTSD

  This study is testing a new type of therapy for veterans with PTSD to see if it helps them feel better compared to the usual treatments they’ve already tried.

  Recruiting Montefiore Medical Center · New York, New York · NCT03755401

NIH-funded research (newest 40 of 272)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how PTSD affects self-control and brain function

  Researchers are studying how PTSD changes the brain’s control over thoughts and actions, and how this might affect Veterans’ daily lives and responses to treatment.

  NIH research VA Boston Health Care System · Boston, United States · NIH-11617299

• Ketamine to boost fear extinction and memory on PTSD patients

  A study testing whether ketamine can help people with PTSD better relearn and forget fear when given in a guided treatment plan.

  NIH research Yale University · New Haven, United States · NIH-11592530

• Treating PTSD and opioid use disorder in residential care with Written Exposure Therapy (WEST)

  A short, patient-friendly plan to adapt a proven PTSD therapy for people with opioid use disorder in residential treatment and test its practicality and impact.

  NIH research University of Maryland Baltimore County · Baltimore, United States · NIH-11588002

• Dynamic PTSD-Related Cognitive Risk in Aging WTC Responders

  This project follows World Trade Center responders as they age to understand how PTSD symptoms relate to changes in thinking skills over time.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11578595

• Identifying brain proteins linked to PTSD and alcohol use disorder

  Researchers are studying brain proteins that may contribute to PTSD and alcohol use disorder in US veterans to find new ways to help people who struggle with both conditions.

  NIH research VA Northern California Health Care Sys · Mather, United States · NIH-11578051

• Transdiagnostic Behavior Therapy for Veterans with Social Anxiety and PTSD Symptoms

  A clinical trial tests whether a flexible brain-behavior therapy helps veterans with social anxiety and PTSD symptoms feel better and engage more in daily life.

  NIH research Ralph H Johnson VA Medical Center · Charleston, United States · NIH-11556448

• PTSD and Autoimmune Diseases: How PTSD Might Cause or Change Risk and What Might Help

  This project looks at whether PTSD in Veterans affects the risk of autoimmune diseases and whether there are factors that influence that risk.

  NIH research Veterans Affairs Med Ctr San Francisco · San Francisco, United States · NIH-11538983

• Onsite PTSD Treatment to Improve MOUD Outcomes for people who inject drugs

  A community-based program will adapt a PTSD therapy and deliver it alongside opioid-use treatments to help people who inject drugs stay engaged in care and improve outcomes.

  NIH research City College of New York · New York, United States · NIH-11538491

• Written Exposure Therapy for Veterans with PTSD and Substance Use Disorder (brief trauma treatment)

  A brief trauma-focused therapy called Written Exposure Therapy is being studied to help veterans who have both PTSD and substance use disorders.

  NIH research VA Connecticut Healthcare System · West Haven, United States · NIH-11533114

• Computationally mapping PTSD to better diagnosis and personalized care

  A research project uses computer tools to find brain-based patterns that could help diagnose PTSD more clearly and tailor treatments for Veterans and others with PTSD.

  NIH research Providence VA Medical Center · Providence, United States · NIH-11522578

• How Veterans move from a positive PTSD screen to VA mental health care

  This project looks at the steps Veterans take after a positive PTSD screen to see how they get connected to VA mental health services.

  NIH research VA Boston Health Care System · Boston, United States · NIH-11515706

• Next steps for PTSD genomics: from loci to function

  A study from Boston University Medical Campus aims to identify genetic factors and brain-cell changes linked to PTSD to help develop better biomarkers and treatments for people with PTSD.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11515325

• Family support to improve PTSD therapy for Veterans

  This adds a short, two-session family program to standard PTSD therapy to help Veterans stay in treatment and feel better.

  NIH research VA Boston Health Care System · Boston, United States · NIH-11513868

• Video and text messages to reduce PTSD and opioid problems after sexual assault

  This project offers a short video in the emergency department plus follow-up text messages to help recent sexual assault survivors limit PTSD symptoms and prevent opioid misuse.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11466249

• Creative Art Teletherapy for Veterans With PTSD

  A teletherapy program called ART-VET is being studied to help veterans with PTSD feel better and stay in treatment.

  NIH research Veterans Health Administration · Gainesville, United States · NIH-11465713

• Web-based training to treat PTSD and substance use together in Veterans

  A web-based training resource helps VA clinicians learn how to provide integrated treatment for Veterans with both PTSD and substance use disorders.

  NIH research Ralph H Johnson VA Medical Center · Charleston, United States · NIH-11458134

• Trauma Recovery with Brain Signals During Written Therapy

  A study at McLean Hospital will track brain activity and sleep patterns to find biomarkers that reflect how Written Exposure Therapy helps people with PTSD.

  NIH research Mclean Hospital · Belmont, United States · NIH-11427453

• Understanding how a seizure/relapse drug may help people with alcohol use disorder and PTSD

  A Mayo Clinic-led study will explore why a popular anticonvulsant (topiramate) works differently for people who have both alcohol use disorder and PTSD, using patient samples and cell-level analysis to find clues for better treatment.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11424107

• Adapting PTSD Treatments to Improve Keeping Veterans in Care

  A study tests delivering PTSD therapies more frequently in a condensed schedule to help Veterans stay in treatment and finish proven therapies.

  NIH research Durham VA Medical Center · Durham, United States · NIH-11423366

• Promoting Retention in Opioid Treatment for Women Experiencing Intimate Partner Violence with PTSD

  A new stepped-care approach helps women on opioid treatment who experience ongoing IPV and PTSD stay in treatment longer and feel better.

  NIH research Yale University · New Haven, United States · NIH-11419015

• Innovative care pathways to screen and treat OUD/PTSD in jail settings

  A new project will try to improve how jail-based programs screen for PTSD and OUD and link people to PTSD therapy and medications for OUD after release.

  NIH research Univ of Arkansas for Med Scis · Little Rock, United States · NIH-11416543

• Genetics of PTSD in people of African ancestry

  This project studies genetic factors linked to PTSD in people with African ancestry to understand why some develop PTSD after trauma.

  NIH research Broad Institute, INC. · Cambridge, United States · NIH-11416424

• Personalized Cognitive Processing Therapy to Improve Everyday Functioning after PTSD

  This project personalizes Cognitive Processing Therapy to better target problems with daily life, relationships, and emotions in Veterans living with PTSD.

  NIH research VA Boston Health Care System · Boston, United States · NIH-11415401

• Genetic and real-time data to understand PTSD and alcohol use together

  A study in city residents with PTSD and alcohol use issues will combine genetic information and real-time diary data to better understand how these conditions influence each other.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11413574

• Web-based moral elevation program for Veterans with PTSD

  A free, online eight-session program helps Veterans with PTSD feel inspired by virtuous acts to improve social functioning and quality of life.

  NIH research Olin Teague Veterans Center · Temple, United States · NIH-11413119

• Smartphone app to support women with PTSD and substance use after sexual assault

  A smartphone app will help deliver an integrated PTSD and substance-use program for sexual assault survivors, aiming to make it easier to get evidence-based support.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11412403

• Mechanisms linking maternal PTSD to how infants feel and react emotionally

  This study looks at how a mother’s posttraumatic stress affects a baby’s early emotional development and the mother–infant relationship.

  NIH research Emory University · Atlanta, United States · NIH-11408596

• WINGS+++: A brief, patient-friendly program to link IPV/PTSD care with opioid treatment for women

  A short, phone-and-app based program helps women with opioid use disorders who experience intimate partner violence and PTSD connect to the right services and support.

  NIH research Columbia Univ New York Morningside · New York, United States · NIH-11402803

• Adaptive PTSD Therapy for Opioid Addiction Patients

  A study is testing a flexible PTSD treatment approach that can be delivered in primary care and by community health workers to people with opioid use disorder and co-occurring PTSD.

  NIH research Rand Corporation · Santa Monica, United States · NIH-11402561

• Genetic links between PTSD and Alcohol Use Disorder in teens and adults

  This grant studies how genetics and life experiences like childhood trauma shape the risk of PTSD and alcohol problems across adolescence into adulthood.

  NIH research Suny Downstate Medical Center · Brooklyn, United States · NIH-11401773

• AI-based Simulated Patients to Train Therapists in Written Exposure Therapy for PTSD

  A Stanford-led project uses an AI-powered simulated patient system to help therapists learn Written Exposure Therapy for PTSD more effectively than workshops alone.

  NIH research Stanford University · Stanford, United States · NIH-11392704

• Center for Responsible and Effective AI Tools to Improve PTSD Care

  A Stanford-led project uses safe, private, and user-friendly AI tools to help deliver evidence-based PTSD therapies to more people, especially in public and rural settings.

  NIH research Stanford University · Stanford, United States · NIH-11392694

• Prediction of alcohol problems and PTSD after trauma in teens

  Teens who experience acute trauma are studied to see if certain biological signals can predict who might develop Alcohol Use Disorder or PTSD.

  NIH research University of Texas at Austin · Austin, United States · NIH-11391105

• Clinician-supported mobile app to boost social support for Veterans with PTSD

  A clinician-supported mobile app called ACTsocial is tested to help Veterans with PTSD build social connections and reduce isolation.

  NIH research Edith Nourse Rogers Memorial Veterans Hospital · Bedford, United States · NIH-11388786

• Gut-borne particles and PTSD after brain injury

  A doctor-research team is studying how tiny gut-borne vesicles might influence PTSD and anxiety after a brain injury, with findings that could lead to new ways to help patients.

  NIH research Henry Ford Health + Michigan State University Health Sciences · East Lansing, United States · NIH-11384595

• Genetics of PTSD and Substance Use in Diverse Populations

  This grant investigates how genes influence PTSD and substance use disorders in diverse groups to improve prevention and treatment.

  NIH research Suny Downstate Medical Center · Brooklyn, United States · NIH-11381617

• Adaptive PTSD care paths to reach more patients in routine clinics

  A patient-friendly plan tests how to sequence simple, scalable PTSD treatments in regular clinics to help more people start and stay in care.

  NIH research Boston Medical Center · Boston, United States · NIH-11380636

• Cognitive Processing Therapy plus Relapse Prevention for people with alcohol problems and PTSD

  This trial offers a combined Cognitive Processing Therapy and relapse-prevention program for adults with alcohol use disorder and PTSD to reduce drinking and PTSD symptoms.

  NIH research Texas A&m University · College Station, United States · NIH-11378367

• Allopregnanolone to help PTSD memories settle more safely

  A study is looking at whether intravenous allopregnanolone can improve how PTSD memories are processed after trauma-focused therapy.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11377436

• Alcohol, approach-avoidance conflicts, and brain circuits in PTSD

  A study looking at how alcohol affects decision-making and brain signals in adults with PTSD to understand why many also have alcohol use problems.

  NIH research University of Texas at Austin · Austin, United States · NIH-11377275

Related topics

Quick answers

How many PTSD clinical trials are recruiting right now?

98, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (75 trials), Sweden (5 trials), Israel (5 trials), Canada (4 trials), France (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 11, Phase 4: 3, Phase 1: 3, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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