Condition

Cannabis Use clinical trials and research

• 36Clinical trials
• 171NIH research projects
• 5Countries

Newest Cannabis Use clinical trials

All recruiting trials (36)

• vEAET-H: a virtual group emotional therapy for chronic pain patients using medical cannabis in Israel

  This study tests a Hebrew, virtual, group-based emotional therapy to see if it can help reduce pain and improve emotional well-being in Israeli adults with chronic musculoskeletal pain who use medical cannabis.

  Recruiting Reuth Rehabilitation Hospital · Tel Aviv · NCT07732062

• Testing warning labels on cannabis packaging to see what design helps people notice risks

  Researchers are testing different cannabis warning labels to see which designs make people notice health risks and think about their use more carefully.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT07701304

• Mobile app to help adults in Quebec use cannabis more safely

  A mobile app is being tested to see if it helps adults who use cannabis non-medically in Quebec use cannabis more safely.

  Recruiting Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT07524985

• Feasibility of a perinatal smoking and cannabis cessation program

  This study tests a perinatal program to help pregnant people quit tobacco and cannabis and stay smoke-free after birth.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07489443

• Psychiatric Symptoms in Methamphetamine Psychosis With or Without Lifetime Cannabis Use

  This study tests whether lifetime cannabis use changes the course and severity of psychiatric symptoms in people hospitalized with methamphetamine-induced psychosis.

  Recruiting Elazığ Mental Health and Diseases Hospital · Elâzığ, Elâzığ and 1 other locations · NCT07459270

• Cannabis use and IV sedation during wisdom tooth removal

  This project will see if people who use cannabis need different IV sedative doses or have different vital signs and breathing during wisdom tooth removal compared with people who don't use cannabis.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT07423195

• Brain imaging to predict teens' response to cannabis treatment

  This project will test whether teens' brain activity during a learning task can predict how well 14–17-year-olds do in a 10-week virtual reward program to reduce cannabis use.

  Recruiting Indiana University · Indianapolis, Indiana · NCT07340554

• Acute Cannabis Effects on Thinking and Mood

  This study tests whether a moderate 20 mg dose of THC affects mood and thinking in adults who use cannabis weekly, using a randomized, placebo-controlled crossover design.

  Recruiting Phase 1 Washington State University · Pullman, Washington · NCT07296874

• Registry to track how cannabis affects cancer symptoms

  This app-based registry enrolls adults with cancer who use cannabis to see if cannabis use is linked to changes in symptoms and supportive medication use.

  Recruiting HealthPartners Institute · Saint Louis Park, Minnesota · NCT07227324

• Precision brain stimulation to reduce cannabis craving in people with schizophrenia

  This trial tests whether targeted brain stimulation can reduce cannabis craving and improve thinking in people with schizophrenia who currently use cannabis.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07196462

• Cannabis use patterns and social and health effects in young adults

  We will follow 18–24-year-olds who use cannabis at least weekly for two years to see if different patterns of product type, frequency, and dosage are linked to social and health outcomes.

  Recruiting Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT07063589

• Effects of cannabis on brain function in depressed adolescents

  This study is testing how using cannabis affects brain function in teenagers who are dealing with depression.

  Recruiting University of Miami · Miami, Florida and 1 other locations · NCT06941298

• Oral saliva testing to detect recent cannabis use in young adults.

  This project will test whether at-home saliva tests can detect recent cannabis use in 18-to-30-year-olds who use cannabis at least once a week.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT06891235

• Treatment for quitting cigarettes and reducing cannabis use

  This study tests if a medication called varenicline can help adults who smoke cigarettes and use cannabis quit smoking and cut down on cannabis use, with support from counseling and online resources.

  Recruiting Phase 3 Medical University of South Carolina · Charleston, South Carolina · NCT06883162

• Effects of cannabis on sleep and light sensitivity in young adults

  This study tests how using and stopping cannabis affects sleep and light sensitivity in young adults aged 18 to 25.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06743373

• Motivational intervention for teens at risk of alcohol and cannabis use

  This study is testing a new motivational program to help teens aged 12-17 who are at risk of using alcohol and cannabis by offering them support either online or in-person.

  Recruiting at 3 sites Rand · Commerce, California and 2 other locations · NCT06699251

• Impact of THC on E-Cigarette Use Behavior

  This study is testing how different doses of THC affect daily e-cigarette users' cravings and use behavior.

  Recruiting Phase 1 Johns Hopkins University · Baltimore, Maryland · NCT06609109

• Impact of THC on Cigarette Smoking Behavior

  This study is testing how different amounts of THC affect smoking habits and cravings in healthy adults who smoke cigarettes and use cannabis.

  Recruiting Phase 1 Johns Hopkins University · Baltimore, Maryland · NCT06609083

• Understanding how cannabis affects mood and perception

  This study is testing how cannabis affects mood and how people feel things like temperature and pain in order to help understand its impact on mental and physical states.

  Recruiting University of Colorado, Boulder · Boulder, Colorado · NCT06588582

• Understanding cannabis use and its effects on depression and suicide risk in adolescents

  This study is trying to see how stopping cannabis use affects depression and suicidal thoughts in teens aged 12-18 who use cannabis daily.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT06576076

• MATAspire: A Web App to Help CSUN Students Prevent Substance Misuse

  A web-app tests a six-week program to help CSUN students build coping skills and reduce use of alcohol, cannabis, nicotine, illicit drugs, and prescription opioid misuse.

  Recruiting California State University, Northridge · Northridge, California · NCT06553196

• Pilot intervention for HIV patients focusing on alcohol use and medication effects

  This study tests a new program to help HIV-positive patients who drink alcohol manage their medications better and reduce risks like falls and memory problems.

  Recruiting Phase 1 Yale University · West Haven, Connecticut · NCT06513819

• Exploring resilience in Black adults facing substance misuse

  This study is trying to see how daily stress and experiences of racism affect substance use in Black young adults and what coping strategies can help them manage these challenges.

  Recruiting at 2 sites University of Washington · Dallas, Texas and 1 other locations · NCT06457841

• Warrior CARE: Cannabis Behavioral Health

  This study tests whether different cannabis compounds (THC, CBD, or THC+CBD) or placebo can help veterans with PTSD and suicidal thoughts over 12 weeks.

  Recruiting Phase 1/2 Wayne State University · Detroit, Michigan · NCT06381180

• Impact of Choline Supplement on Brain Development in Babies of Cannabis-Using Pregnant Women

  This study is testing if giving a choline supplement to pregnant women who used cannabis can help improve their babies' brain development in the first few months of life.

  Recruiting Phase 1 University of Colorado, Denver · Aurora, Colorado · NCT06379971

• Understanding the effects of alcohol and cannabis intoxication using EEG

  This study tests how alcohol and cannabis, alone or together, affect brain activity and behavior in heavy drinkers and regular cannabis users aged 21-50.

  Recruiting Colorado State University · Fort Collins, Colorado · NCT06259916

• How marijuana (THC) and tobacco interact when used together

  This test tries to see if combining marijuana (THC) and tobacco changes blood drug levels and how people feel and respond physically in adults who regularly use both.

  Recruiting Phase 2 University of California, San Francisco · San Francisco, California · NCT05999383

• Examining how different cannabis edibles affect the body and mind

  This study tests how different cannabis edibles like chocolates, gummies, and drinks affect the body and mind of healthy adults.

  Recruiting Phase 1 Johns Hopkins University · Baltimore, Maryland · NCT05602649

• A program to help teens reduce cannabis and alcohol use

  This study is testing a new computer program to help teens aged 13-17 cut down on their use of cannabis and alcohol.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05486234

• SV2A in Older Adults

  This study is testing if a certain brain protein in older adults can help us understand memory and thinking changes as they age.

  Recruiting Phase 1/2 Yale University · New Haven, Connecticut · NCT05465538

• Investigating cognitive function in psychosis patients and cannabis users

  This study is testing how taking a break from cannabis for 28 days affects thinking skills and brain activity in people with psychosis and those who use cannabis but don’t have mental health issues.

  Recruiting Douglas Mental Health University Institute · Montreal, Quebec · NCT05445180

• Examining how cannabis affects alcohol consumption

  This study is testing how different types of cannabis affect drinking habits in heavy drinkers who use cannabis regularly.

  Recruiting Phase 2 Brown University · Providence, Rhode Island · NCT05389930

• Environmental exposures, including cannabis, and lung cancer

  Adults with primary lung cancer aged 18–59 will give blood and hair samples so researchers can try to link cannabis use and other environmental exposures to the cancer.

  Recruiting Centre Chirurgical Marie Lannelongue · Le Plessis-Robinson and 2 other locations · NCT05119244

• Effects of stopping cannabis use on depression and cognition

  This study is testing if stopping cannabis use for 28 days can help people with depression and cannabis addiction feel better and think more clearly.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT04935619

• Long-term effects of cannabis smoking on lung health

  This study is trying to see how smoking cannabis over a long time affects lung health in people aged 18 to 85.

  Recruiting Western University, Canada · London, Ontario · NCT03909477

• Genetic counselling to prevent mental health issues from cannabis use

  This study is trying to see if genetic counselling can help young people aged 12 to 21 understand their risk of mental health issues from cannabis use and make better choices about using it.

  Recruiting Nova Scotia Health Authority · Halifax, Nova Scotia · NCT03601026

NIH-funded research (newest 40 of 171)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Hemp-derived CBD for reducing cannabis use in high-THC concentrate users

  A randomized, placebo-controlled trial tests whether hemp-derived CBD can help adults who mainly use high-potency cannabis concentrates reduce their cannabis use.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-11567759

• Understanding how minority stress affects cannabis use in sexual minorities

  A research project follows young adult sexual minorities to see how daily stress and coping help explain cannabis use and related problems.

  NIH research University of Massachusetts Amherst · Hadley, United States · NIH-11544966

• Terminal cannabinoid CB1 receptor changes in schizophrenia and cannabis use

  This grant studies how cannabis use and schizophrenia together affect a brain receptor (CB1) and what that could mean for memory and symptoms.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11520628

• Cannabis policies and prenatal cannabis use: how laws affect moms and babies

  This grant studies how changes in recreational cannabis laws influence cannabis use during pregnancy and health outcomes for mothers and children.

  NIH research Boston College · Chestnut Hill, United States · NIH-11459463

• Genetic, Social, and Environmental Factors Shaping Early Cannabis Use in Youth

  A study with young people will look at how genes, surroundings, and behavior come together to predict who might start using cannabis early and how to prevent it.

  NIH research Baylor University · Waco, United States · NIH-11453679

• Cannabis use and how young adults feel about its effects

  This grant helps a researcher study how young adults experience cannabis, including both positive and negative effects, and how these feelings relate to use patterns.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11451475

• Perinatal drinking and cannabis use patterns across pregnancy and postpartum

  This project looks at how drinking and cannabis use change before, during, and after pregnancy to understand risks for moms and babies.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11447800

• Alcohol and cannabis use and helping in sexual violence situations

  A bystander-focused study explores how alcohol and cannabis by those nearby affect whether a person will step in during sexual violence events.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11446517

• Varenicline for Cannabis Use Disorder in Men and Women

  A clinical trial will test if varenicline helps people with cannabis use disorder, with a focus on differences between men and women and added counseling to support craving and mood management.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11445421

• Neural and computational markers linked to reward that may predict cannabis use escalation in young adults with anhedonia

  This study follows young adults with anhedonia to see how their brain responses to rewards and computational signals relate to increasing cannabis use over time.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11432812

• Cannabis Use Disorder and Opioid Health Risks in Veterans: A Long-Term VA Study

  A long-term study of veterans looking at how cannabis use disorder and its treatment relate to opioid-related health problems and hospital visits.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11415661

• Partnering with pregnant people to create a new plan to cut tobacco and cannabis use

  A community-driven project with pregnant and postpartum women to design a tailored approach for reducing tobacco and cannabis use during and after pregnancy.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11412943

• Reducing cannabis use to improve daily functioning

  Reducing cannabis use may improve everyday functioning and quality of life for adults with cannabis use disorders.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11408819

• A Digital Therapy to Help Adults Cut Heavy Cannabis Use

  A digital treatment delivered via a mobile app aims to help adults with cannabis use disorder reduce heavy cannabis use and stay engaged with self-managed wellness.

  NIH research Mobile Health Interventions LLC · Hastings on Hudson, United States · NIH-11408338

• Cannabis and the endocannabinoid system in OA pain and recovery after knee replacement

  This grant explores how cannabis use and the body’s endocannabinoid system influence inflammatory knee pain before and after knee replacement surgery, with hopes of guiding better pain treatment.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11406070

• Heavy cannabis use, brain function, and PrEP care for young people at risk for HIV

  A two-phase study will look at how heavy cannabis use affects brain function and how that relates to HIV prevention and PrEP engagement among young people in Chicago.

  NIH research University of Chicago · Chicago, United States · NIH-11405057

• Postpartum cannabis use and stress: how they’re linked

  This project studies how stress and hormones around birth may influence whether women return to using cannabis after pregnancy.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11404799

• Sex differences in how cannabis use and stress affect the brain in young adults

  A study focused on young adults explores how cannabis use and stress interact differently for men and women and what this means for brain development and coping.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11404795

• How heavy cannabis use affects thinking and HIV prevention in young Black sexual minority men

  This project looks at whether heavy cannabis use changes thinking and decision-making and how that affects taking HIV prevention medicine (PrEP) among young Black sexual minority men.

  NIH research University of Chicago · Chicago, United States · NIH-11402104

• ADHD in adults, cannabis use, and related consequences

  This NIH grant explores how ADHD in adults relates to cannabis use and its consequences, with a focus on sex differences and real-world impact.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11400420

• One-session computerized program with text reminders to help manage distress and reduce cannabis use

  A short computer-delivered emotional skills session plus just-in-time text reminders to help people who use cannabis and struggle with handling distress learn to tolerate emotions and cut back on use.

  NIH research Florida State University · Tallahassee, United States · NIH-11399242

• Brief parent guide to reduce college students’ drinking and cannabis use

  A short, parent-focused program helps college students cut back on drinking and cannabis use.

  NIH research Pennsylvania State University, the · University Park, United States · NIH-11398286

• Cannabis use and immunotherapy for cancer patients: long-term effects

  We’re studying how cannabis use affects people with cancer who are receiving immune-based treatments over a year.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11397515

• Caffeine and cannabis use and their effects on thinking skills in teens and young adults

  This grant studies how caffeine and cannabis together affect thinking and memory in adolescents and young adults who use both substances.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11395626

• CB1 receptor changes in schizophrenia and cannabis use linked to memory problems

  This grant studies how the brain’s cannabinoid system may work differently in people with schizophrenia who use cannabis, especially affecting memory and thinking.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11395592

• Understanding how cannabis use and genes change the brain to increase depression risk

  A research project at Yale is exploring how cannabis use might change specific brain cells and genes, potentially making people more vulnerable to depression.

  NIH research Yale University · New Haven, United States · NIH-11395269

• Epigenetics and cannabis effects on HIV brain inflammation

  This grant tests whether cannabinoids like THC and CBD can reprogram brain immune cells to reduce neuroinflammation in people living with HIV.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11392673

• Advancing Pregnenolone as a Therapy for Cannabis Use Disorder with Depression

  A study tests pregnenolone as a therapy for adults who have both cannabis use disorder and depression and aims to reduce cannabis use and improve mood.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11392064

• How heavy cannabis use may affect thinking and use of PrEP in young people

  This project looks at whether heavy cannabis use changes young people's thinking, sexual behavior, and whether they start and stay on PrEP.

  NIH research University of Chicago · Chicago, United States · NIH-11390927

• Telehealth and mobile help to reduce cannabis use in young adults

  A remote program using telehealth coaching and a mobile app helps 18–26 year-olds with cannabis use disorder to cut back on daily use.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11387655

• How stressful moments affect drinking and cannabis use in young adults

  A study with 18-year-olds to understand how personally stressful experiences influence how much they drink and use cannabis, and how worries and coping help explain that link.

  NIH research University of Washington · Seattle, United States · NIH-11383564

• Trajectories of Cannabis Use in Pregnancy

  This study follows pregnant people to understand how cannabis use patterns change across pregnancy and how those patterns relate to birth outcomes and child development.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11383471

• Cannabis use and alcohol craving and drinking in people starting alcohol treatment

  This study follows people starting alcohol treatment to see how using cannabis affects their cravings and how much alcohol they drink, using real-time tracking.

  NIH research Brown University · Providence, United States · NIH-11380616

• Cannabis use and its link to PrEP use and HIV risk

  This project looks at whether cannabis use affects PrEP use, adherence, and HIV-related risk among HIV-negative people who could benefit from PrEP.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11380477

• Cannabis use, stress hormones, and sleep in women of childbearing age

  This project studies how recreational cannabis affects sleep in women who are of childbearing age, using detailed brain and body measurements over two months.

  NIH research Rutgers, the State Univ of N.j. · Piscataway, United States · NIH-11379547

• Brief motivational mobile program to help young adults reduce high-frequency cannabis use

  A new, smartphone-based program with personalized feedback and text messages aims to help young adults who frequently use cannabis reduce their use.

  NIH research University of Washington · Seattle, United States · NIH-11379529

• Moment-to-moment risk factors for cannabis use in young adults

  This project tracks young adults' daily moods and moments to find when cannabis use is most likely.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11377053

• Cannabis use after trauma: how acute stress and fear affect cannabis outcomes

  This study observes adults after a traumatic event to understand how stress and fear during the early days to months after trauma influence cannabis use and related problems.

  NIH research Brown University · Providence, United States · NIH-11374389

• Cannabis use and HIV: how pot may affect aging and HIV outcomes

  A big study will look at how cannabis use and cannabis use disorder affect older people with HIV, including how it relates to aging problems and HIV treatment success.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11371946

• Real-time help for young adults using alcohol and cannabis together

  A mobile app-based program tests when and what types of real-time support (mindfulness tips or protective strategies) best help 18- to 24-year-olds who use alcohol and cannabis together.

  NIH research University of Oregon · Eugene, United States · NIH-11361853

Related topics

Quick answers

How many Cannabis Use clinical trials are recruiting right now?

36, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (27 trials), Canada (6 trials), Turkey (Türkiye) (1 trial), France (1 trial), Israel (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 6, Phase 1/2: 2, Phase 2: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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