Examining the effects of combined therapy for schizophrenia
Cognitive Behavioural Therapy Compared to Cognitive Remediation for Schizophrenia-Spectrum Disorders
This study is testing whether combining two therapies, one for managing thoughts and another for improving cognitive skills, can help people with schizophrenia do better in their daily lives compared to using just one of the therapies.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 360 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | University of Toronto Academic / other |
| Locations | 2 sites (Scarborough Village, Ontario and 1 other locations) |
| Trial ID | NCT05731414 on ClinicalTrials.gov |
What this trial studies
This trial investigates the effectiveness of combining Cognitive Behavioural Therapy for Psychosis (CBTp) and Cognitive Remediation Therapy (CR) for individuals with schizophrenia-spectrum disorders. It aims to identify predictors of treatment response to determine whether patients benefit more from the combined intervention or from either therapy alone. The study will be one of the largest of its kind, focusing on improving functional recovery and community functioning, which are often inadequately addressed by current treatments. By evaluating both the combined intervention and individual responses, the trial seeks to provide insights into optimizing treatment strategies for this population.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-65 diagnosed with schizophrenia-spectrum disorders who can communicate in English.
Not a fit: Patients with neurodevelopmental disabilities or those who have received CBT or CR in the past six months may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more personalized and effective treatment options for individuals with schizophrenia-spectrum disorders.
How similar studies have performed: While there have been numerous studies on monotherapy for schizophrenia, this approach of combining CBT and CR is novel and has not been previously tested in a randomized controlled trial.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 18-65 years * Diagnosed with schizophrenia-spectrum disorders * Can read, write, and speak English Exclusion Criteria: * Neurodevelopmental disability or neurocognitive disorder * CBT or CR in the past 6 months
Where this trial is running
Scarborough Village, Ontario and 1 other locations
- University of Toronto Scarborough — Scarborough Village, Ontario, Canada (Recruiting)
- Ontario Shores Centre for Mental Health Sciences (Ontario Shores) — Whitby, Ontario, Canada (Recruiting)
Study contacts
- Principal investigator: Michael W Best, PhD, C.Psych — University of Toronto Scarborough
- Study coordinator: Hanna Hamzai, HBSc
- Email: hanna.hamzai@mail.utoronto.ca
- Phone: 6476896098
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.