Psychosis Risk Outcomes Network
Official title: ProNET: Psychosis-Risk Outcomes Network
Funded at Yale University · NIH-11493630 · Data updated 2026-11-12
This project follows people at high risk for psychosis and collects brain scans, blood tests, speech samples, and smartphone data to find signs that predict future symptoms.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 8, 2020 |
| Project end | May 31, 2026 |
| Funding year | 2026 |
| Award (this year) | $381,980 |
| NIH project number | 3U01MH124639-05SB |
| Project ID | NIH-11493630 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people identified as clinical high risk for psychosis—those with recent or worsening mild psychotic symptoms or a decline in functioning—who can attend regular study visits for two years.
✕Less likely to help
People without signs of psychosis risk, those unable to travel to a participating site, or those unwilling to complete repeated visits and tests may not benefit or be eligible.
What this research studies
If you join, the network will collect detailed information including MRI and EEG brain scans, blood and genetic samples, speech tests, cognitive and symptom measures, and passive smartphone sensors. About 1,040 people with clinical high risk (CHR) and 260 healthy volunteers across 26 international sites will be seen at eight visits over 24 months, with key biomarkers repeated to track change over time. Clinicians and researchers will combine these measures to see which patterns map onto worsening, improvement, or transition to psychosis. Some exploratory work will also use natural speech and real-time phone surveys to capture everyday changes in thinking and behavior.
Why it matters
Potential benefit: If successful, this work could help predict who is likely to develop psychosis earlier and support more personalized steps to prevent or reduce illness.
How similar studies have gone: Smaller studies have found promising brain, behavioral, and biological markers, but this is one of the largest international, multi-modal efforts to confirm and combine those findings.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Woods, Scott W — Yale University
- Study coordinator: Woods, Scott W
Related research
Other NIH-funded projects on the same topics.
-
Psychosis in diverse settings across the world
This project studies how psychotic disorders show up and respond to treatment in adults with diverse backgrounds, including populations in Africa, the Caribbean, and other Global South settings.
-
Psychosis in Diverse Settings: Understanding Symptoms and Treatment Across Global South
A human-facing study will look at how psychotic disorders present and respond to treatment in adults from Africa, the Caribbean, and other Global South settings, using genetic and clinical data.
-
A new online brain-scan-style tool to spot early psychosis risk
A new online-based set of tasks and a computer model aims to identify people at high risk for developing psychosis earlier and more accurately.
-
Genetic clues for early-onset psychosis in Latino youth
This project looks at the genes of young people with early-onset psychosis and compares them with similar youths without psychosis to find genetic factors that contribute to the illness.
-
Biomarkers to tailor rehab for Veterans with schizophrenia
A clinician-scientist is developing a brain-based biomarker to guide personalized rehabilitation for Veterans with schizophrenia.
-
Computational analysis of facial expression in early psychosis
Aims to develop computer-based measures of facial expression in people at risk for or with schizophrenia to help track symptoms and guide future trials.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.