Trauma therapy for patients with PTSD and psychotic disorders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of Prolonged Exposure therapy for outpatients suffering from both post-traumatic stress disorder (PTSD) and a psychotic disorder. Conducted at the Medical School Hamburg, the study will randomly assign participants to receive trauma therapy or be placed in a waiting group. The trial aims to assess the reduction of PTSD and psychosis symptoms over time, with a total of 56 patients expected to be enrolled. The study will utilize a linear mixed model for data analysis, ensuring robust results despite potential dropout rates.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Presence of a psychotic disorder (F20) or affective disorder with psychotic symptoms(F30) according to DSM-5.
* comorbid post-traumatic stress disorder (PTSD) according to DSM-5 (CAPS-5 score ≥ 23)
* At least 18 years old
* Good knowledge of the German language
* Willingness to participate in randomisation and trauma-focused therapy

Exclusion Criteria:

* Changes in neuroleptic or antidepressant therapy within the last 4 weeks (exclusion of drug effects).
* Any substance dependence with continued use other than nicotine and/or caffeine dependence.
* IQ of 70 or less
* Acute suicidality
* Pregnant women

Where it's running

• Medicalschool Hamburg
  Hamburg, Germany Recruiting

Study contacts

• Study coordinator: Susanne Sarkar, Dr.
• Email: susanne.sarkar@hafencity-institut-psychotherapie.de
• Phone: 00491733968992

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Non-invasive vagus nerve stimulation (gammaCore) for PTSD

  This study will test whether the handheld gammaCore device, which delivers mild electrical stimulation to the vagus nerve through the neck, can help adults with PTSD reduce their symptoms.

  Recruiting Acacia Clinics · Sunnyvale, California · NCT07523685

• Non‑trauma PTSD treatment for veterans and service members with mild or moderate TBI

  This pilot will test a non‑trauma psychotherapy program to help veterans and service members with mild or moderate traumatic brain injury who have PTSD.

  Recruiting The University of Texas Health Science Center at San Antonio · Fort Hood, Texas · NCT07351305

• Psilocybin-assisted therapy for PTSD after sexual assault

  This trial will test whether a single 25 mg oral dose of psilocybin combined with therapy helps cisgender women who have PTSD from a sexual assault.

  Recruiting Phase 2 Sunstone Medical · Rockville, Maryland · NCT06902974

• Short-term therapy for PTSD symptoms

  This study is testing a week-long therapy to see if it can help adults with PTSD feel better and reduce their symptoms.

  Recruiting Ben-Gurion University of the Negev · Beersheba · NCT06826937

• Augmented reality-enhanced exposure therapy for PTSD in U.S. military personnel

  This tests whether adding augmented reality to standard exposure therapy helps U.S. military veterans and active-duty adults with PTSD.

  Recruiting Wayne State University · Charleston, South Carolina · NCT06740487

• Working memory training to improve fear extinction in veterans with PTSD

  This study is testing if a special memory training program can help veterans with PTSD learn to manage their fears better.

  Recruiting VA Office of Research and Development · San Diego, California · NCT06629064

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.