Preventing psychosis in people at high risk
ProNET: Psychosis-Risk Outcomes Network
Using brain scans, genetics, blood tests, speech samples, and smartphone data to predict outcomes and guide care for people with early signs of psychosis.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11493631 on NIH RePORTER |
What this research studies
If you take part, you would join over 1,000 people who show early warning signs of psychosis across a network of sites and be followed for two years. The project collects MRI and EEG brain scans, genetic and body-fluid samples, speech and language recordings, clinical interviews, and passive smartphone sensor and survey data at several visits. Healthy volunteers will provide comparison data. Participation typically involves clinic visits for scans and tests, providing samples, and using a phone app for short surveys and passive monitoring.
Who could benefit from this research
Good fit: Ideal candidates are people with clinical high-risk features for psychosis (recently emerging attenuated psychotic symptoms, functional decline, or similar risk signs) who can attend in-person visits and use a smartphone for monitoring.
Not a fit: People who already have a diagnosed full psychotic disorder or those unable/unwilling to complete in-person scans, sample collection, or phone-based monitoring are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, this work could help doctors predict which people are most likely to develop psychosis and tailor early, more personalized care.
How similar studies have performed: Smaller CHR cohorts have found promising biomarker signals but results have not reliably predicted outcomes at large scale, so this larger multi-site effort aims to improve reliability.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Woods, Scott W — Yale University
- Study coordinator: Woods, Scott W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.