Investigating cognitive function in psychosis patients and cannabis users

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines the neurobiological basis of cognitive changes associated with 28 days of cannabis abstinence in individuals with psychosis and non-psychiatric controls who use cannabis. Participants will be randomized into either a cannabis abstinent group or a non-abstinent control group and will undergo magnetic resonance imaging (MRI) at the beginning and after 28 days. The study aims to explore brain activity, morphology, and the correlation between cognitive recovery and brain changes following abstinence. This research could provide insights into the cognitive impairments linked to cannabis use and inform future interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Able to provide informed consent in English or French
* Heavy cannabis use (defined as weekly cannabis use for at six months) and/or DSM-5 diagnosis of CUD
* Have a Full-Scale IQ ≥ 75
* Meet DSM-5 criteria for a psychotic disorder (psychosis patient arm only)
* Be an outpatient receiving a stable dose of medication(s) for at least two months (psychosis patient arm only)
* Clinically stable (as measured by the PANSS-6, total score \<30) (psychosis patient arm only)

Exclusion Criteria:

* current SUD (other than CUD)
* MRI contraindications
* Positive urine screen for psychoactive substances other than cannabis, nicotine, or caffeine
* Current suicidal or homicidal ideation
* Head injury requiring hospitalization or loss of consciousness \> 5 minutes
* Current medical diseases that requires hospitalization or regular monitoring
* Being pregnant
* DSM-5 Axis 1 diagnosis (other than CUD) (non-psychiatric controls only)
* Taking psychotropic medication

Where it's running

• Douglas Mental Health University Institute
  Montreal, Quebec, Canada Recruiting

Study contacts

• Principal investigator: Rachel Rabin, Ph. D. — Douglas Mental Health University Institute
• Study coordinator: Charlene Osei-Afrifa
• Email: aimh.research@gmail.com
• Phone: (514) 761-6131

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.