Understanding the genetics and immune factors in youth with psychosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to analyze the genomes and immune systems of 15 children and adolescents admitted to Rady Children's Hospital with psychotic symptoms or schizophrenia. By utilizing advanced genome and protein sequencing technologies, the research seeks to identify genetic and autoimmune factors that may contribute to psychosis. The findings could enhance diagnostic accuracy and inform treatment strategies for affected individuals. The study also explores the prevalence of these factors in adolescents experiencing their first psychotic episode.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Individual in whom one of the following criteria is met:

1. Child/adolescent admitted to the Rady Children's CAPS with symptoms of first break psychosis

   OR
2. Biological parents of child/adolescent enrolled in this study for the purposes of reflex testing. Family members are eligible for participation in this study if they are presumed genetically related to a patient participant.

Exclusion Criteria:

Child/Adolescent patients who do not meet any of the inclusion criteria, or those who:

1. Already received any prior whole genome sequencing or exome sequencing.
2. Unable to approach the family or patient for enrollment.
3. Unable to obtain informed consent.
4. Family members are ineligible for participation in this study if:

   1. They are known to not be genetically related to the child/adolescent patient participant
   2. They are a member of a protected research population

Where it's running

• Rady Children's Hospital San Diego
  San Diego, California, United States Recruiting

Study contacts

• Principal investigator: Aaron Besterman, MD — Rady Pediatric Genomics & Systems Medicine Institute
• Study coordinator: Aaron Besterman, MD
• Email: abesterman@health.ucsd.edu
• Phone: 858-576-1700

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.