Understanding the genetics and immune factors in youth with psychosis
Multiomic Diagnostics in Child and Adolescent Psychosis
This study is testing the genes and immune systems of young people with psychosis to see if certain factors are linked to their symptoms and can help improve their diagnosis and treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 15 (estimated) |
| Ages | 7 Years to 17 Years |
| Sex | All |
| Sponsor | Rady Pediatric Genomics & Systems Medicine Institute Academic / other |
| Locations | 1 site (San Diego, California) |
| Trial ID | NCT05457140 on ClinicalTrials.gov |
What this trial studies
This study aims to analyze the genomes and immune systems of 15 children and adolescents admitted to Rady Children's Hospital with psychotic symptoms or schizophrenia. By utilizing advanced genome and protein sequencing technologies, the research seeks to identify genetic and autoimmune factors that may contribute to psychosis. The findings could enhance diagnostic accuracy and inform treatment strategies for affected individuals. The study also explores the prevalence of these factors in adolescents experiencing their first psychotic episode.
Who should consider this trial
Good fit: Ideal candidates include children and adolescents admitted with first break psychosis symptoms.
Not a fit: Patients who have previously undergone whole genome or exome sequencing may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for youth experiencing psychosis.
How similar studies have performed: While the approach of combining genomic and immunological assessments is innovative, similar studies have shown promise in identifying underlying causes of psychosis.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Individual in whom one of the following criteria is met: 1. Child/adolescent admitted to the Rady Children's CAPS with symptoms of first break psychosis OR 2. Biological parents of child/adolescent enrolled in this study for the purposes of reflex testing. Family members are eligible for participation in this study if they are presumed genetically related to a patient participant. Exclusion Criteria: Child/Adolescent patients who do not meet any of the inclusion criteria, or those who: 1. Already received any prior whole genome sequencing or exome sequencing. 2. Unable to approach the family or patient for enrollment. 3. Unable to obtain informed consent. 4. Family members are ineligible for participation in this study if: 1. They are known to not be genetically related to the child/adolescent patient participant 2. They are a member of a protected research population
Where this trial is running
San Diego, California
- Rady Children's Hospital San Diego — San Diego, California, United States (Recruiting)
Study contacts
- Principal investigator: Aaron Besterman, MD — Rady Pediatric Genomics & Systems Medicine Institute
- Study coordinator: Aaron Besterman, MD
- Email: abesterman@health.ucsd.edu
- Phone: 858-576-1700
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.