Improving social functioning and reducing psychosis risk through cognitive training
Official title: Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk in Adolescents at Clinical High Risk for Psychosis
Run by Northwell Health · NCT05131035 · Data updated 2026-11-12
This study is testing a 10-week program to see if cognitive training can help teenagers at risk for psychosis improve their thinking skills and social interactions.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 14 Years to 20 Years |
| Sex | All |
| Enrollment | 54 (estimated) |
| Sponsor | Northwell Health Academic / other |
| Locations | 1 site (Glen Oaks, New York) |
| Status | Recruiting |
| Started | October 28, 2021 |
| Main results expected | May 31, 2026 |
| Study ends | May 31, 2026 |
| Registry record updated | November 24, 2025 |
| Trial ID | NCT05131035 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adolescents who meet Clinical High Risk criteria for psychosis and exhibit specific cognitive deficits.
✕Probably not a fit
Patients with a diagnosed schizophrenia-spectrum disorder or significant cognitive impairments may not benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This intervention focuses on enhancing processing speed in adolescents at clinical high risk for psychosis through a program called SCORES (Specific Cognitive Remediation with Support). Over 10 weeks, participants engage in cognitive training exercises and receive group support to improve their cognitive abilities and social skills. The study aims to evaluate the effectiveness of this approach in reducing symptoms associated with psychosis and improving overall social functioning. The intervention includes performance-based rewards and game-like tasks to boost motivation and engagement.
Why it matters
Potential benefit: If successful, this intervention could significantly improve social functioning and reduce the risk of developing psychosis in at-risk adolescents.
How similar studies have gone: Other studies have shown promise in using cognitive remediation approaches to improve outcomes in similar populations, suggesting potential for success in this novel intervention.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Meet Clinical High Risk (CHR) criteria on the Structured Interview for Psychosis Risk Syndromes, defined by the presence of at least one attenuated positive symptom at a moderate to severe level * A score representing 0.5 SD below the mean on Animal Naming, Trails A or BACS: Symbol Coding from the MATRICS Consensus Cognitive Battery (MCCB). Exclusion Criteria: * Any DSM 5 Schizophrenia-Spectrum diagnosis * Non-English speaking * Past or current history of a clinically significant central nervous system disorder (e.g., seizure disorder) * Estimated IQ\<70 * Significant head injury * Significant substance abuse * Significant visual or auditory impairment.
Where it's running
-
Northwell Health- The Zucker Hillside Hospital
Glen Oaks, New York, United States Recruiting
Study contacts
- Principal investigator: Ricardo E Carrion, Ph.D. — Northwell Health
- Study coordinator: Ricardo E Carrion, Ph.D.
- Email: rcarrion@northwell.edu
- Phone: 718-470-8788
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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State Representation in Early Psychosis 2
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Accelerated Brain Stimulation for Young People at Risk of Psychosis
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This program tests a peer-supported, clinician-led suicide prevention group for young people at clinical high risk for psychosis to see if it helps reduce suicidal thoughts and support recovery.
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Combined brain stimulation and yoga for improving cognition in psychosis
This study tests whether active brain stimulation plus yoga can improve thinking skills and daily function in adults with psychosis.
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See if an early-detection program reduces time to treatment for first-episode psychosis
We test whether a large, region-wide early-detection program can shorten the time from first psychotic symptoms to treatment and help people function better later.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.