Network to understand early signs and outcomes in people at high risk for psychosis
Official title: ProNET: Psychosis-Risk Outcomes Network
Funded at Yale University · NIH-11493633 · Data updated 2026-11-12
This project will collect brain scans, EEG, genetics, blood tests, speech samples and smartphone data from people at clinical high risk for psychosis to find patterns that predict who develops psychosis over two years.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 8, 2020 |
| Project end | May 31, 2026 |
| Funding year | 2026 |
| Award (this year) | $399,335 |
| NIH project number | 3U01MH124639-05SE |
| Project ID | NIH-11493633 on NIH RePORTER |
Who could benefit from this research
✓Could help
People identified as clinical high risk for psychosis (often adolescents or young adults with recent changes such as attenuated psychotic symptoms, brief psychotic episodes, or related functional decline) who can attend repeated visits at a participating site.
✕Less likely to help
People without signs of being at clinical high risk for psychosis, those unable to travel to a participating site, or those seeking immediate changes in clinical treatment are unlikely to receive direct benefit from participation.
What this research studies
If I join, the team will follow people identified as being at clinical high risk for psychosis across 26 international sites and collect many types of data over 24 months. They will do MRI and EEG brain measures, cognitive and symptom interviews, genetic testing, blood and other body-fluid tests, recorded speech, and passive smartphone sensor data. About 1,040 high-risk participants will be followed at eight timepoints and biomarkers will be collected at two timepoints, with 260 healthy volunteers completing baseline testing for comparison. The goal is to link these measures to clinical outcomes and symptom trajectories that matter for treatment.
Why it matters
Potential benefit: If successful, this work could help doctors predict who is most likely to develop psychosis and guide earlier, more personalized care.
How similar studies have gone: Smaller, single-site studies have identified some promising biomarkers but results are mixed, and this large multi-site effort is a novel step toward more reliable prediction.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Woods, Scott W — Yale University
- Study coordinator: Woods, Scott W
Related research
Other NIH-funded projects on the same topics.
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Psychosis in diverse settings across the world
This project studies how psychotic disorders show up and respond to treatment in adults with diverse backgrounds, including populations in Africa, the Caribbean, and other Global South settings.
-
Psychosis in Diverse Settings: Understanding Symptoms and Treatment Across Global South
A human-facing study will look at how psychotic disorders present and respond to treatment in adults from Africa, the Caribbean, and other Global South settings, using genetic and clinical data.
-
A new online brain-scan-style tool to spot early psychosis risk
A new online-based set of tasks and a computer model aims to identify people at high risk for developing psychosis earlier and more accurately.
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Genetic clues for early-onset psychosis in Latino youth
This project looks at the genes of young people with early-onset psychosis and compares them with similar youths without psychosis to find genetic factors that contribute to the illness.
-
Biomarkers to tailor rehab for Veterans with schizophrenia
A clinician-scientist is developing a brain-based biomarker to guide personalized rehabilitation for Veterans with schizophrenia.
-
Computational analysis of facial expression in early psychosis
Aims to develop computer-based measures of facial expression in people at risk for or with schizophrenia to help track symptoms and guide future trials.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.