Investigating the links between social isolation, loneliness, and mental illness
Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness
This study is trying to see how feeling lonely and isolated affects people with serious mental illnesses like schizophrenia and psychosis, using brain scans and smartphone tools to understand their daily experiences.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 18 Years to 55 Years |
| Sex | All |
| Sponsor | Massachusetts General Hospital Academic / other |
| Locations | 1 site (Charlestown, Massachusetts) |
| Trial ID | NCT04940663 on ClinicalTrials.gov |
What this trial studies
This research aims to explore how social isolation and loneliness are connected to neurobehavioral mechanisms in individuals with serious mental illnesses, such as psychosis and schizophrenia. By utilizing advanced neuroimaging and smartphone-based assessments, the study will examine the dynamic interactions of these experiences in daily life and their impact on functioning. The findings could lead to new therapeutic targets to improve the quality of life for those affected by serious mental illnesses.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 18-55 who have experienced a psychotic disorder or mood disorder.
Not a fit: Patients with neurological disorders, current substance use disorders, or those not proficient in English may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new treatments that enhance daily functioning and overall quality of life for individuals with serious mental illnesses.
How similar studies have performed: Previous studies have indicated correlations between social isolation, loneliness, and mental health, but this approach is novel in its use of advanced neuroimaging and dynamic assessments.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. 18-55 years old 2. Experienced a psychotic disorder or mood disorder Exclusion Criteria: 1. Any neurological disorder or current substance use disorder (during the past 6 months) 2. Not proficient in English 3. A recent change in medication, or an acute symptom presentation 4. Standard exclusion criteria for participation in an MRI scan (e.g., presence of metal in the body, claustrophobia, a history of head trauma).
Where this trial is running
Charlestown, Massachusetts
- Massachusetts General Hospital — Charlestown, Massachusetts, United States (Recruiting)
Study contacts
- Principal investigator: Daphne J Holt, MD, PhD — Massachusetts General Hospital
- Study coordinator: Daphne J Holt, MD, PhD
- Email: dholt@partners.org
- Phone: 617-726-7618
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.