Investigating the links between social isolation, loneliness, and mental illness

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research aims to explore how social isolation and loneliness are connected to neurobehavioral mechanisms in individuals with serious mental illnesses, such as psychosis and schizophrenia. By utilizing advanced neuroimaging and smartphone-based assessments, the study will examine the dynamic interactions of these experiences in daily life and their impact on functioning. The findings could lead to new therapeutic targets to improve the quality of life for those affected by serious mental illnesses.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. 18-55 years old
2. Experienced a psychotic disorder or mood disorder

Exclusion Criteria:

1. Any neurological disorder or current substance use disorder (during the past 6 months)
2. Not proficient in English
3. A recent change in medication, or an acute symptom presentation
4. Standard exclusion criteria for participation in an MRI scan (e.g., presence of metal in the body, claustrophobia, a history of head trauma).

Where it's running

• Massachusetts General Hospital
  Charlestown, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Daphne J Holt, MD, PhD — Massachusetts General Hospital
• Study coordinator: Daphne J Holt, MD, PhD
• Email: dholt@partners.org
• Phone: 617-726-7618

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.