PREDICT: Data and AI tools to study psychosis risk in youth
Official title: Psychosis Risk Evaluation, Data Integration and Computational Technologies (PREDICT): Data Processing, Analysis, and Coordination Center
Funded at Brigham and Women's Hospital · NIH-11527266 · Data updated 2026-11-12
A national effort uses big data and smart computer tools to find new clues that predict psychosis risk in children and teens who show early signs.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 9, 2020 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $160,533 |
| NIH project number | 3U24MH124629-06S1 |
| Project ID | NIH-11527266 on NIH RePORTER |
Who could benefit from this research
✓Could help
Youth aged 0–18 years identified as clinical high risk for psychosis or with related attenuated symptoms.
✕Less likely to help
Youth not at risk for psychosis or those outside the CHR criteria may not benefit from this data-focused project.
What this research studies
This project brings together researchers to combine many data sets about adolescents at clinical high risk for psychosis. It will use advanced algorithms and artificial intelligence to find patterns across studies, focusing on outcomes beyond just psychosis. The goal is to identify biomarkers and subtypes of CHR that can guide future trials and treatments. The work involves coordinating data processing, analysis, and data sharing across centers to overcome variability and improve predictive models.
Why it matters
Potential benefit: If successful, the initiative could lead to earlier, more precise interventions for youth at risk of psychosis and related adverse outcomes.
How similar studies have gone: Previous CHR studies show that integrating diverse data can reveal meaningful patterns, suggesting potential success for this approach.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Shenton, Martha E. — Brigham and Women's Hospital
- Study coordinator: Shenton, Martha E.
Related research
Other NIH-funded projects on the same topics.
-
Psychosis in diverse settings across the world
This project studies how psychotic disorders show up and respond to treatment in adults with diverse backgrounds, including populations in Africa, the Caribbean, and other Global South settings.
-
Psychosis in Diverse Settings: Understanding Symptoms and Treatment Across Global South
A human-facing study will look at how psychotic disorders present and respond to treatment in adults from Africa, the Caribbean, and other Global South settings, using genetic and clinical data.
-
A new online brain-scan-style tool to spot early psychosis risk
A new online-based set of tasks and a computer model aims to identify people at high risk for developing psychosis earlier and more accurately.
-
Genetic clues for early-onset psychosis in Latino youth
This project looks at the genes of young people with early-onset psychosis and compares them with similar youths without psychosis to find genetic factors that contribute to the illness.
-
Biomarkers to tailor rehab for Veterans with schizophrenia
A clinician-scientist is developing a brain-based biomarker to guide personalized rehabilitation for Veterans with schizophrenia.
-
Computational analysis of facial expression in early psychosis
Aims to develop computer-based measures of facial expression in people at risk for or with schizophrenia to help track symptoms and guide future trials.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.